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What is the Goal of Radiation Therapy - ✔✔Is to sterilize a targeted tumor
completely while preserving the integrity of surrounding normal
structures.
Principles of Radiation Therapy - ✔✔High-energy ionizing radiation
destroys the cancer cell's ability to grow and multiply. Some cells are
directly damaged by the ionizing rays or particles. More cells are indirectly
affected when the ionizing rays or particles penetrate the cell's nucleus and
interact with the water content of the nucleus to form oxygen radicals.
Radiosensitivity of Cancer Cells - ✔✔Radiosensitivity of cells depend on
several factors:
Type of Cell
Phase of the Cell Cycle
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, Division rate of the cell
Degree of differentiation
Oxygenation
Radiation Therapy Limitations - ✔✔Body tissues have limits to the amount
of radiation that can be tolerated. Exceeding those limits can result in
serious complications.
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Principles of Radiation Therapy - ✔✔Radiation dose is determined by:
Radiosensitivity of the tumor.
Normal tissue tolerance.
Volume of tissue to be irradiated.
- ✔✔Radiation generates highly reactive free radical molecules that
irreparably alter the cell's DNA structure, thereby rendering the cell
incapable of proliferation.
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