BB 451 Final Exam questions well
answered 100%
Statins - correct answer ✔✔drugs that inhibit HMG-CoA Reductase and reduce
cholesterol by inhibiting its synthesis
Carnitine Acyltransferase - correct answer ✔✔replaces Acyl-CoA with Carnitine
and then moves it through and switches them back out on the inside of the
mitochondria
Acyl-CoA Dehydrogenase - correct answer ✔✔similar action as succinate
dehydrogenase in TCA cycle, Three types, Medium and Short chain enzymes are in
mitochondria while long chain are in peroxisomes
Enoyl-CoA Isomerase - correct answer ✔✔converts a 3,4-cis double bond to a 2,3-
trans double bond
2,4-dienoyl-CoA Reductase - correct answer ✔✔acts on intermediates that have
double bonds at 2,3 and 4,5 and uses NADPH to make one 3,4-cis double bond
Acetyl-CoA Carboxylase - correct answer ✔✔adds a carboxyl group to Acetyl-CoA
to make Malonyl-CoA
Phosporylated Acetyl-CoA Carboxylase - correct answer ✔✔Mostly inactive
Acetyl-CoA Carboxylase
,Activated Acetyl-CoA Carboxylase - correct answer ✔✔not phosphorylated, high
levels of citrate
Corticosteroids - correct answer ✔✔inhibit production of arachidonic from by
phospholipase A2 (PLA2)
Prostaglandin Synthase (COX) - correct answer ✔✔enzyme that makes
prostaglandins (hormone like compounds) from arachidonic acid
NSAIDS - correct answer ✔✔inhibit COX enzymes
Leptin - correct answer ✔✔adipokine that suppress hunger
ghrelin - correct answer ✔✔adipokine that signals to eat more
resistin - correct answer ✔✔adipokine involved in insulin resistance
PRPP Synthetase - correct answer ✔✔makes R5P to PRPP and uses ATP, Inhibited
by high levels of phosphates and ADP
PRPP Amidotransferase - correct answer ✔✔End product of action is IMP, Both
AMP and GMP present inhibit enzyme completely, one or the other inhibits partly
, IMP Dehydrogenase - correct answer ✔✔makes GMP from IMP and eventually
GTP, Inhibited by GMP, powered by ATP
Adenylosuccinate Synthetase - correct answer ✔✔a. uses IMP to make
adenylosuccinate and then AMP and eventually ATP, Inhibited by AMP, releases
Fumarate to TCA cycle
Adenylate Kinase - correct answer ✔✔turns AMP to ADP, AMP + ATP - 2ADP is the
normal reaction, but the reverse will be used to make ATP, that's why AMP is an
indicator of low energy.
NDPK - correct answer ✔✔Enzyme that catalyzes NDPs to NTPs
CPS-2 - correct answer ✔✔enzyme that makes carbamoyl phosphate, Inhibited by
UMP
ATCase - correct answer ✔✔makes carbamoyl aspartate from carbamoyl
phosphate and aspartate, inhibited by CTP, activated by ATP and aspartate
OMP Decarboxylase - correct answer ✔✔OMP to UMP, speeds the reaction by
10^17
CTP Synthetase - correct answer ✔✔UTP to CTP, Inhibited by phosphorylation at
two different places, activated by GTP, Inhibited by CTP (lots of CTP will inhibit this
enzyme but UMP is not in a high concentration so you make UTP)
answered 100%
Statins - correct answer ✔✔drugs that inhibit HMG-CoA Reductase and reduce
cholesterol by inhibiting its synthesis
Carnitine Acyltransferase - correct answer ✔✔replaces Acyl-CoA with Carnitine
and then moves it through and switches them back out on the inside of the
mitochondria
Acyl-CoA Dehydrogenase - correct answer ✔✔similar action as succinate
dehydrogenase in TCA cycle, Three types, Medium and Short chain enzymes are in
mitochondria while long chain are in peroxisomes
Enoyl-CoA Isomerase - correct answer ✔✔converts a 3,4-cis double bond to a 2,3-
trans double bond
2,4-dienoyl-CoA Reductase - correct answer ✔✔acts on intermediates that have
double bonds at 2,3 and 4,5 and uses NADPH to make one 3,4-cis double bond
Acetyl-CoA Carboxylase - correct answer ✔✔adds a carboxyl group to Acetyl-CoA
to make Malonyl-CoA
Phosporylated Acetyl-CoA Carboxylase - correct answer ✔✔Mostly inactive
Acetyl-CoA Carboxylase
,Activated Acetyl-CoA Carboxylase - correct answer ✔✔not phosphorylated, high
levels of citrate
Corticosteroids - correct answer ✔✔inhibit production of arachidonic from by
phospholipase A2 (PLA2)
Prostaglandin Synthase (COX) - correct answer ✔✔enzyme that makes
prostaglandins (hormone like compounds) from arachidonic acid
NSAIDS - correct answer ✔✔inhibit COX enzymes
Leptin - correct answer ✔✔adipokine that suppress hunger
ghrelin - correct answer ✔✔adipokine that signals to eat more
resistin - correct answer ✔✔adipokine involved in insulin resistance
PRPP Synthetase - correct answer ✔✔makes R5P to PRPP and uses ATP, Inhibited
by high levels of phosphates and ADP
PRPP Amidotransferase - correct answer ✔✔End product of action is IMP, Both
AMP and GMP present inhibit enzyme completely, one or the other inhibits partly
, IMP Dehydrogenase - correct answer ✔✔makes GMP from IMP and eventually
GTP, Inhibited by GMP, powered by ATP
Adenylosuccinate Synthetase - correct answer ✔✔a. uses IMP to make
adenylosuccinate and then AMP and eventually ATP, Inhibited by AMP, releases
Fumarate to TCA cycle
Adenylate Kinase - correct answer ✔✔turns AMP to ADP, AMP + ATP - 2ADP is the
normal reaction, but the reverse will be used to make ATP, that's why AMP is an
indicator of low energy.
NDPK - correct answer ✔✔Enzyme that catalyzes NDPs to NTPs
CPS-2 - correct answer ✔✔enzyme that makes carbamoyl phosphate, Inhibited by
UMP
ATCase - correct answer ✔✔makes carbamoyl aspartate from carbamoyl
phosphate and aspartate, inhibited by CTP, activated by ATP and aspartate
OMP Decarboxylase - correct answer ✔✔OMP to UMP, speeds the reaction by
10^17
CTP Synthetase - correct answer ✔✔UTP to CTP, Inhibited by phosphorylation at
two different places, activated by GTP, Inhibited by CTP (lots of CTP will inhibit this
enzyme but UMP is not in a high concentration so you make UTP)
