MCB 408 Exam 1 Questions with Correct Answers Graded A+
1. If a microbe was coated by C3b, phagocytosis would be induced by which of the
following macrophage receptors?
a. FcγR
b. CR2
c. SR-A I
d. MR
e. CR1 - Answers e. CR1
2. A gram negative bacteria is recognized by the toll like receptors on the outside of
a cell. Which of the following would form heterodimers?
a. TLR 1
b. TLR 2
c. TLR 6
d. A and B
e. A and B; B and C - Answers e. A and B; B and C
A viral double stranded RNA has been introduced by a virus within the cytoplasm
of a cell. Which of these proteins/sensors will most likely detect this viral strand?
a. RIG-I
b. NLRP3
c. MDA-5
d. NOD1
e. None of the Above - Answers c. MDA-5
4. The release of which cytokine associated with sepsis can cause septic shock?
a. TNF-⍺
b. IL-14
,c. IL-72
d. IFN-⍺
e. TGF-ββ1 - Answers a. TNF-⍺
5. The major function of IFN-⍺ in humans is to:
a. Inhibit TLR expression
b. Induce MHC I expression
c. Lyse gram negative bacterial cell membranes
d. Promote vasodilation
e. Inhibit flagellin polymerization - Answers b. Induce MHC I expression
6. Which of the following is false concerning TLR's?
a. TLR's can detect intracellular and extracellular pathogens
b. TLR's can be found freely floating in the cytosol
c. TLR's are associated with endogenous pyrogens
d. TLR's activate NFkB signaling pathways
5.None of the above - Answers b. TLR's can be found freely floating in the cytosol
7. Which of the following diseases is associated with a loss of function mutation in
NOD2?
a. Chlamydia
b. Blau Syndrome
c. Early-onset Sarcoidosis
d. Muckle-Wells Disease
e. Crohn's Disease - Answers e. Crohn's Disease
8. A new DNA virus is found to inhibit the transcription of interferon genes by
inactivating an essential protein in the host viral DNA response pathway. Which of
the following proteins could the virus be inhibiting?
, a. RIG-like Receptors
b. cGAS
c. MDA-5
d. NOD1
e. JAK - Answers b. cGAS
9. The assembly of NADPH oxidase subunits is promoted by which signaling
pathway?
a. JAK-STAT
b. Receptor Tyrosine Kinases
c. G-Protein Coupled Receptors/Rac
d. NFkB
e. STING - Answers c. G-Protein Coupled Receptors/Rac
10. RIG-I serves as a sensor for several intracellular infections. Mice deficient in
RIG-I are highly susceptible to infection by several kinds of single-stranded RNA
viruses. From the list below, which are they NOT susceptible to?
a. Paramyxovirus
b. Rhabdovirus
c. Orthomyxovirus
d. Flavivirus
e. Picornavirus - Answers e. Picornavirus
11. Which of the following cell types is least likely to be associated with innate
immunity?
a. cytotoxic T-lymphocytes
b. macrophages
c. natural killer cells
1. If a microbe was coated by C3b, phagocytosis would be induced by which of the
following macrophage receptors?
a. FcγR
b. CR2
c. SR-A I
d. MR
e. CR1 - Answers e. CR1
2. A gram negative bacteria is recognized by the toll like receptors on the outside of
a cell. Which of the following would form heterodimers?
a. TLR 1
b. TLR 2
c. TLR 6
d. A and B
e. A and B; B and C - Answers e. A and B; B and C
A viral double stranded RNA has been introduced by a virus within the cytoplasm
of a cell. Which of these proteins/sensors will most likely detect this viral strand?
a. RIG-I
b. NLRP3
c. MDA-5
d. NOD1
e. None of the Above - Answers c. MDA-5
4. The release of which cytokine associated with sepsis can cause septic shock?
a. TNF-⍺
b. IL-14
,c. IL-72
d. IFN-⍺
e. TGF-ββ1 - Answers a. TNF-⍺
5. The major function of IFN-⍺ in humans is to:
a. Inhibit TLR expression
b. Induce MHC I expression
c. Lyse gram negative bacterial cell membranes
d. Promote vasodilation
e. Inhibit flagellin polymerization - Answers b. Induce MHC I expression
6. Which of the following is false concerning TLR's?
a. TLR's can detect intracellular and extracellular pathogens
b. TLR's can be found freely floating in the cytosol
c. TLR's are associated with endogenous pyrogens
d. TLR's activate NFkB signaling pathways
5.None of the above - Answers b. TLR's can be found freely floating in the cytosol
7. Which of the following diseases is associated with a loss of function mutation in
NOD2?
a. Chlamydia
b. Blau Syndrome
c. Early-onset Sarcoidosis
d. Muckle-Wells Disease
e. Crohn's Disease - Answers e. Crohn's Disease
8. A new DNA virus is found to inhibit the transcription of interferon genes by
inactivating an essential protein in the host viral DNA response pathway. Which of
the following proteins could the virus be inhibiting?
, a. RIG-like Receptors
b. cGAS
c. MDA-5
d. NOD1
e. JAK - Answers b. cGAS
9. The assembly of NADPH oxidase subunits is promoted by which signaling
pathway?
a. JAK-STAT
b. Receptor Tyrosine Kinases
c. G-Protein Coupled Receptors/Rac
d. NFkB
e. STING - Answers c. G-Protein Coupled Receptors/Rac
10. RIG-I serves as a sensor for several intracellular infections. Mice deficient in
RIG-I are highly susceptible to infection by several kinds of single-stranded RNA
viruses. From the list below, which are they NOT susceptible to?
a. Paramyxovirus
b. Rhabdovirus
c. Orthomyxovirus
d. Flavivirus
e. Picornavirus - Answers e. Picornavirus
11. Which of the following cell types is least likely to be associated with innate
immunity?
a. cytotoxic T-lymphocytes
b. macrophages
c. natural killer cells
