NR 507 midterm Exam
Hypersensitivity: Type 1 - answer-Mediated IgE
-inflammation due to mast cell degranulation
-anaphylactic, asthma, hay fever
treatment: epinephrine
Hypersensitivity: Type 2 - answer-Cytotoxic reaction: tissue specific
-binds to the antigen ON THE CELL SURFACE
-macrophages are primary effectors cells involved
cause tissue damage or alter function
Hypersensitivity 2 - answer-Graves Disease (hyperthyroidism) -alters function not
destroy
-blood transfusions reaction- transfused erythrocytes are destroyed by agglutination or
lysis
-drug allergies
-hemolytic anemia
Hypersensitivity: type 3 - answer-Not organ specific
-antibody binds to soluble antigen OUTSIDE THE CELL SURFACE that was released
into the blood or bodily fluids, and the complex is then deposited in the tissues
Hypersensitivity: Type 3 - answer-rheumatoid arthritis
-Systemic Lupus Erythematosus (SLE)
-Raynaud's
Hives (urticaria) - answerHypersensitivity Type 1
First responders to innate the immune system - answerNeutrophils
Allergic contact dermatitis - answerHypersensitivity Type IV
Type 2 cytotoxic hypersensitivity mediated by: - answer-IgG IgM
-macrophages are primary effort cells
-
Serum Sickness - answertype 3 hypersensitivity
Hypersensitivity IV, - answer-is more of a delayed immune response.
-mediated T-cells attack tissue directly (no antibodies)
, Autoimmune - answer-diseases in which the body makes antibodies directed against its
own tissues
-
Primary immunodeficiency - answer-Genetic; inherited
-result of single gene defects
-B and T cell deficiencies
secondary immunodeficiency - answer-acquired
Common cause of secondary immunodeficiency - answerMalnutrition
Most patients diagnosed with SLE will have a positive ? - answerantinuclear antibody
(ANA)
SLE (lupus) - answer-Facial rash
-vasculitis
- tissue inflammation
Renal disease associated with autoimmunity? - answerGlomerulonephritis
Sjogren's syndrome - answerInflammation in salivary and lacrimal glands
SLE - answerAutoantibodies and auto-active t-cells against DNA and nucleoprotein
Sjögren's syndrome immune changes: - answerAutoantibodies and auto-reactive t-cells
against apoptotic cells
rheumatoid arthritis manifestations: - answerJoint inflammation, stiffness, pain, loss of
range of motion
Rheumatoid Arthritis immune changes: - answerT-cells and B cells against joint
associated antigens
MS manifestations - answerFormation of sclerotic plaque in the brain, leads to Muscle
weakness and ataxia
MS immune changes - answerT-cells against brain antigens
___ measures the average size of RBCs - answerMCV
Anemia occur by... - answer-impaired RBC production
-excessive blood loss
- increased RBC production
Hypersensitivity: Type 1 - answer-Mediated IgE
-inflammation due to mast cell degranulation
-anaphylactic, asthma, hay fever
treatment: epinephrine
Hypersensitivity: Type 2 - answer-Cytotoxic reaction: tissue specific
-binds to the antigen ON THE CELL SURFACE
-macrophages are primary effectors cells involved
cause tissue damage or alter function
Hypersensitivity 2 - answer-Graves Disease (hyperthyroidism) -alters function not
destroy
-blood transfusions reaction- transfused erythrocytes are destroyed by agglutination or
lysis
-drug allergies
-hemolytic anemia
Hypersensitivity: type 3 - answer-Not organ specific
-antibody binds to soluble antigen OUTSIDE THE CELL SURFACE that was released
into the blood or bodily fluids, and the complex is then deposited in the tissues
Hypersensitivity: Type 3 - answer-rheumatoid arthritis
-Systemic Lupus Erythematosus (SLE)
-Raynaud's
Hives (urticaria) - answerHypersensitivity Type 1
First responders to innate the immune system - answerNeutrophils
Allergic contact dermatitis - answerHypersensitivity Type IV
Type 2 cytotoxic hypersensitivity mediated by: - answer-IgG IgM
-macrophages are primary effort cells
-
Serum Sickness - answertype 3 hypersensitivity
Hypersensitivity IV, - answer-is more of a delayed immune response.
-mediated T-cells attack tissue directly (no antibodies)
, Autoimmune - answer-diseases in which the body makes antibodies directed against its
own tissues
-
Primary immunodeficiency - answer-Genetic; inherited
-result of single gene defects
-B and T cell deficiencies
secondary immunodeficiency - answer-acquired
Common cause of secondary immunodeficiency - answerMalnutrition
Most patients diagnosed with SLE will have a positive ? - answerantinuclear antibody
(ANA)
SLE (lupus) - answer-Facial rash
-vasculitis
- tissue inflammation
Renal disease associated with autoimmunity? - answerGlomerulonephritis
Sjogren's syndrome - answerInflammation in salivary and lacrimal glands
SLE - answerAutoantibodies and auto-active t-cells against DNA and nucleoprotein
Sjögren's syndrome immune changes: - answerAutoantibodies and auto-reactive t-cells
against apoptotic cells
rheumatoid arthritis manifestations: - answerJoint inflammation, stiffness, pain, loss of
range of motion
Rheumatoid Arthritis immune changes: - answerT-cells and B cells against joint
associated antigens
MS manifestations - answerFormation of sclerotic plaque in the brain, leads to Muscle
weakness and ataxia
MS immune changes - answerT-cells against brain antigens
___ measures the average size of RBCs - answerMCV
Anemia occur by... - answer-impaired RBC production
-excessive blood loss
- increased RBC production
