m m m m m m
(8TH EDITION BY KARCH) WITH 1 -59 CHAPTERS.
m m m m m m m
,Chapter 01 - Introduction to Drugs
m m m m m
Amnursem workingm inm radiologym administersm iodinem tom am patientm whom ism havingm amcomputedm tomography(C
T)mscan.mThemnursemworkingmonmthemoncologym unitmadministersm chemotherapymtompatientsmwhomhav
emcancer.mAtmthemPublicmHealthmDepartment,mamnursemadministersmammeasles-mumps-
rubellam(MMR)mvaccinem tom am 14-month-
oldm childm asm am routinem immunization.m Whichm branchm ofm pharmacologym bestmdescribesm themactions
m ofm allm threemnurses?
Pharmacoeconomicsm
Pharmacotherapeutics
Pharmacodynamicsm
m
PharmacokineticsmA
ns: B
Feedback:
Pharmacologymismthemstudymofmthembiologicmeffectsmofmchemicals.mNursesmareminvolvedmwithmclinical
mpharmacologym orm pharmacotherapeutics,m whichm ism am branchm ofm pharmacologym thatm dealsm withm them uses
m ofmdrugsm tomtreat,m prevent,m andm diagnose m disease.m Themradiology m nursemism administering mam drugmtom
helpmdiagnosemamdisease.mThemoncologymnursemismadministeringmamdrugmtomhelpmtreatmamdisease.
Pharmacoeconomicsm includesm anym costsm involvedm inm drugm therapy.m Pharmacodynamicsm involvesm howm a
mdrugmaffectsmthem bodymandm pharmacokinetics mism howmthembodymactsmonm the m body.
Amphysicianm hasmorderedm intramuscularm (IM)m injectionsm ofmmorphine,m am narcotic,m everym 4mhoursm asm neede
dformpainminmammotormvehiclemaccidentmvictim.mThemnursemismawaremthismdrugmhasmamhighmabusem
potential.mUndermwhatmcategorymwouldmmorphinembemclassified?
SchedulemIm
SchedulemIIm
SchedulemIII
m SchedulemI
VmAns: B
Feedback:
Narcoticsm withm amhighm abusem potentialm arem classifiedm asm Schedulem IImdrugsm becausemofmseverem dependence
, liability.mSchedulemImdrugsmhavemhighmabusempotentialmandmnomacceptedmmedicalmuse.mSchedulemIIImd
rugsmhavemamlessermabusempotentialmthanmIImandmanmacceptedmmedicalmuse.mSchedulemIVmdrugsmhav
emlowmabusempotentialmandmlimitedmdependencemliability.
Whenminvolvedm inm phasem IIIm drugm evaluationm studies,m whatm responsibilitiesm wouldm them nursem have?
m Workingmwithmanimalsmwhomaremgivenmexperimentalmdrugs
ChoosingmappropriatempatientsmtombeminvolvedminmthemdrugmstudymMon
itoringmandmobservingmpatientsmcloselymformadversemeffectsmConductin
gm researchmtomdeterminem effectivenessm ofmthem drugmAns: C
Feedback:
PhasemIIImstudiesminvolvem usem ofmamdrugm inmamvastmclinicalm populationm inm whichm patientsm arem askedm tomr
ecordmanym symptomsm theym experiencem whilem takingm them drugs.m Nursesm maym bem responsiblem form helpi
ngm collectmandmanalyzemtheminformationm tom bem sharedm withm them Foodm andmDrugmAdministrationm (FDA)m
butm wouldm notmconductmresearchmindependentlymbecausemnursesmdomnotmprescribemmedications.mUsemofma
nimalsminmdrugmtestingmismdonem inm them preclinicalmtrials.mSelectmpatientsmwhomareminvolvedminmphasemIIms
tudiesm tom participateminm studiesm wherem them participantsm havem them diseasem them drugm ism intendedm tom treat.
m Thesem patientsm aremmonitoredm closelym form drugm actionm andm adversem effects.m Phasem Im studiesm involvem he
althym humanm volunteersmwhom arem usuallym paidm form theirm participation.m Nursesm maym observem form advers
em effectsm andm toxicity.
Whatm conceptm ismconsideredm whenm genericm drugsm arem substitutedm formbrandm namem drugs?mBioavaila
bility
Criticalmconcentratio
nmDistribution
Half-
lifemAns: A
Feedback:
Bioavailabilitymismthemportionmofm amdosem ofm amdrugmthatmreachesmthem systemicm circulationm andmismavailab
lem tomactmonmbodymcells.mBindersmusedminmamgenericmdrugmmaymnotmbemthemsamemasmthosemusedminmth
embrandmnamemdrug.mTherefore,mthemwaymthembodymbreaksmdownmandmusesmthemdrugmmaymdiffer,mwhi
chmmaymeliminatemamgenericmdrugmsubstitution.mCriticalmconcentrationmismthemamountmofmamdrugmthat
m ism neededm tomcausemamtherapeutic meffect mandmshouldmnotmdiffermbetweenmgeneric mandmbrandmnamemm
edications.
Distributionmismthemphasem ofm pharmacokinetics,m whichm involvesm them movementm ofm am drugm tom them body’s
mtissuesm andm ism the
, samem inmgenericm andmbrandm namem drugs.mAmdrug’smhalf-
lifem ismthemtimem itmtakesmformthem amountmofm drugmtomdecreasem tom halfm them peakm level,m whichm shouldm notm ch
angem whenm substitutingm am genericm medication.
Amnursemismassessingm thempatient’sm homem medicationm use.mAftermlisteningm tom thempatientm listmcurrentmmedic
ations,mthemnursemasksm whatmprioritym question?
Domyoumtakemanym genericm medications?
Arem anym ofmthesem medicationsm orphanm drugs?
Aremthesem medicationsm safemtom takem duringm pregnancy?m
Domyoumtakemanymover-the-countermmedications?
Ans: D
Feedback:
Itmismimportantmformthemnursemtomspecificallymquestionmusemofmover-the-
countermmedicationsmbecausempatientsm maym notmconsiderm themm important.m Them patientm ismunlikelym tom k
nowmthem meaningmofmorphanm drugsmunlessmtheymtoomaremhealthmcaremproviders.mSafetymduringmpregna
ncy,musemofmamgenericmmedication,mormclassificationmofmorphanmdrugsmaremthingsmthempatientmwouldmb
emunablemtomanswermbutmcouldmbemfoundminmreferencembooksmifmthemnursemwishesmtomresearchmthem.
Afterm completingm am coursem onmpharmacologym form nurses,m whatm willm them nursem know?mEveryt
hingmnecessarymformsafemandmeffectivemmedicationmadministration
Currentmpharmacologicmtherapy;mthemnursem willmnotmrequirem ongoingm educationm form5myears.m
Generalm drugm information;m them nursem canm consultm am drugm guidem form specificm drugm informati
on.mThemdrugmactionsmthatmaremassociatedmwithmeachmclassificationmofmmedicationmAns:
C
Feedback:
Aftermcompletingm ampharmacologym coursem nursesm willm havem generalmdrugm informationm neededm form safem
andmeffectivem medicationm administrationm butm willm needm tom consultmam drugmguidem formspecificm drugminfor
mationmbeforemadministeringmanymmedication.mPharmacologymismconstantlymchanging,m withm newm drugs
m enteringmthemmarketmandmnewmusesmform existingmdrugsm identified.mContinuingm educationminmpharmacol
ogymismessentialmtomsafempractice.mNursesmtendmtombecomemfamiliarmwithmthemmedicationsmtheymadminister
m mostmoften,m butm therem willm alwaysm bem am needm tom researchm newmdrugsm andm alsom thosem them nursem ism notm
familiarm withmbecausemnomnursemknowsmallmmedications.