PATHOPHYSIOLOGY
THEBIOLOGICBASISFORDISEASEINADULTSANDCHILDREN
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8thEdition
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KathrynL.McCance,SueE.Huether
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Contents
Chapter 01: Cellular Biology ........................................................................................................................... 4
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Chapter 02: Altered Cellular and Tissue Biology: Environmental Agents ....................................................... 18
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Chapter 03: The Cellular Environment: Fluids and Electrolytes, Acids and Bases........................................... 31
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Chapter 04: Genes and Genetic Diseases ...................................................................................................... 44
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Chapter 05: Genes, Environment-Lifestyle, and Common Diseases.............................................................. 55
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Chapter 06: Epigenetics and Disease ............................................................................................................ 63
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Chapter 07: Innate Immunity: Inflammation and Wound Healing ................................................................. 68
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Chapter 08: Adaptive Immunity ................................................................................................................... 83
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Chapter 09: Alterations in Immunity and Inflammation ................................................................................ 95
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Chapter 10: Infection.................................................................................................................................. 108
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Chapter 11: Stress and Disease ................................................................................................................... 117
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Chapter 12: Cancer Biology ......................................................................................................................... 124
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Chapter 13: Cancer Epidemiology ............................................................................................................... 137
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Chapter 14: Cancer in Children.................................................................................................................... 143
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Chapter 15: Structure and Function ofthe Neurologic System ................................................................... 148
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Chapter 16: Pain, Temperature Regulation, Sleep, andSensory Function ................................................... 159
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Chapter 17: Alterations in Cognitive Systems,Cerebral Hemodynamics, and Motor Function ................... 174
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Chapter 18: Disorders ofthe Central and Peripheral Nervous Systems and the Neuromuscular Junction
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................................................................................................................................................................ 188
Chapter 19: Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders ................................. 199
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Chapter 20: Alterations of Neurologic Function in Children ........................................................................ 206
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Chapter 21: Mechanisms ofHormonal Regulation ...................................................................................... 213
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Chapter 22: Alterations ofHormonal Regulation ......................................................................................... 222
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Chapter 23: Obesity and Disorders of Nutrition .......................................................................................... 234
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Chapter 24: Structure and Function ofthe Reproductive Systems.............................................................. 239
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Chapter 25: Alterations of the Female Reproductive System...................................................................... 249
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Chapter 26: Alterations of the Male Reproductive System ......................................................................... 259
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Chapter 27: Sexually Transmitted Infections .............................................................................................. 265
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Chapter 28: Structure and Function ofthe Hematologic System ................................................................ 273
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Chapter 29: Alterations ofErythrocytes, Platelets, and Hemostatic Function ............................................. 283
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Chapter 30: Alterations of Leukocyte and Lymphoid Function .................................................................... 293
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Chapter 31: Alterations of Hematologic Function in Children ...................................................................... 300
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Chapter 32: Structure and Function ofthe Cardiovascular and Lymphatic Systems .................................... 311
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Chapter 33: Alterations of Cardiovascular Function .................................................................................... 324
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Chapter 34: Alterations of Cardiovascular Function in Children ................................................................... 338
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Chapter 35: Structure and Function ofthePulmonary System .................................................................... 346
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Chapter 36: Alterations ofPulmonary Function ......................................................................................... 356
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Chapter 37: Alterations ofPulmonary Function in Children ......................................................................... 373
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Chapter 38: Structure and Function ofthe Renal and Urologic Systems ...................................................... 381
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Chapter 39: Alterations ofRenal and Urinary Tract Function ...................................................................... 391
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Chapter 40: Alterations ofRenal and Urinary Tract Function in Children ...................................................... 401
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Chapter 41: Structure and Function oftheDigestive System ....................................................................... 409
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Chapter 42: Alterations ofDigestive Function ............................................................................................. 421
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Chapter 43: Alterations ofDigestive Function in Children ........................................................................... 432
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Chapter 44: Structure and Function ofthe Musculoskeletal System .......................................................... 441
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Chapter 45: Alterations ofMusculoskeletal Function ................................................................................. 453
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Chapter 46: Alterations ofMusculoskeletal Function in Children ................................................................ 466
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Chapter 47: Structure, Function, and Disorders of the Integument.............................................................. 475
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Chapter 48: Alterations of the Integument in Children................................................................................ 486
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Chapter 49: Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults ......................................... 494
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Chapter 50: Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children ...................................... 502
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, TestBank -Pathophysiology: The BiologicBasis forDisease in Adults and Children(8th)
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Chapter01:CellularBiology
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MULTIPLE CHOICE pw
1. Whichstatement best describes the cellular function of metabolic absorption?
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a. Cells can produceproteins. pw pw pw
b. Cells can secrete digestive enzymes. pw pw pw pw
c. Cells can takein and use nutrients. pw pw pw pw pw
d. Cells can synthesize fats. pw pw pw
ANS: C p w
In metabolic absorption, all cells take in and use nutrients and other substances from their
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surroundings. The remainingoptions arenot inclusive in their descriptions of cellular
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metabolicabsorption.
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PTS: p w p w 1 DIF: Cognitive Level: Remembering pw pw
2. Whereismost of acell’s geneticinformation, includingRNA and DNA, contained?
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a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome
ANS: C p w
Thenucleus contains the nucleolus, a small dense structure composed largelyof RNA, most ofthe cellular
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DNA, and the DNA-binding proteins, such as the histones, which regulate its activity.
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The mitochondria are responsible for cellular respiration and energyproduction.
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p Ribosomes’chieffunction is to provide sites for cellularprotein synthesis. Lysosomes functionas
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the intracellular digestive system.
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PTS: p w p w 1 DIF: Cognitive Level: Remembering pw pw
3. Whichcomponent ofthe cell produces hydrogen peroxide(H2O2)byusingoxygento
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a. Lysosomes
b. Peroxisomes
c. Ribosomes
d. Endosome
ANS: B p w