PATHOPHYSIOLOGY
THEBIOLOGICBASISFORDISEASEINADULTSANDCHILDREN
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8thEdition
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KathrynL.McCance,SueE.Huether
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Contents
Chapter01:CellularBiology ............................................................................................................................. 4
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Chapter02:Altered Cellular andTissueBiology: Environmental Agents ........................................................... 18
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Chapter03:TheCellularEnvironment:Fluids andElectrolytes, Acids andBases................................................ 31
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Chapter04:GenesandGeneticDiseases......................................................................................................... 44
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Chapter 05:Genes, Environment-Lifestyle,and Common Diseases................................................................. 55
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Chapter06:Epigenetics and Disease .............................................................................................................. 63
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Chapter07:Innate Immunity:InflammationandWound Healing .................................................................... 68
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Chapter08:Adaptive Immunity ..................................................................................................................... 83
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Chapter09:Alterationsin Immunity andInflammation ................................................................................... 95
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Chapter10:Infection................................................................................................................................... 108
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Chapter11:StressandDisease ..................................................................................................................... 117
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Chapter12:CancerBiology .......................................................................................................................... 124
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Chapter13:CancerEpidemiology ................................................................................................................ 137
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Chapter14:Cancerin Children ..................................................................................................................... 143
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Chapter 15: Structure andFunction oftheNeurologicSystem ....................................................................... 148
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Chapter16:Pain,Temperature Regulation, Sleep, andSensory Function....................................................... 159
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Chapter 17: AlterationsinCognitive Systems,Cerebral Hemodynamics,and Motor Function ....................... 174
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Chapter18:Disordersofthe CentralandPeripheral Nervous Systems andthe Neuromuscular Junction
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................................................................................................................................................................ 188
Chapter19:Neurobiologyof Schizophrenia,MoodDisorders,and AnxietyDisorders ..................................... 199
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Chapter 20: Alterations ofNeurologicFunction inChildren ........................................................................... 206
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Chapter21:MechanismsofHormonalRegulation ....................................................................................... 213
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Chapter22:Alterations ofHormonalRegulation .......................................................................................... 222
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Chapter23:Obesity andDisordersof Nutrition ............................................................................................. 234
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Chapter 24: Structure andFunctionoftheReproductive Systems ................................................................. 239
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Chapter25:Alterationsofthe Female Reproductive System ......................................................................... 249
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Chapter26:Alterationsofthe Male Reproductive System............................................................................. 259
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Chapter27:Sexually Transmitted Infections ................................................................................................ 265
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Chapter 28: Structure andFunction oftheHematologic System .................................................................... 273
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Chapter29:AlterationsofErythrocytes,Platelets, andHemostatic Function ................................................. 283
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Chapter30:AlterationsofLeukocyte andLymphoid Function ....................................................................... 293
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Chapter31:AlterationsofHematologic Functionin Children ......................................................................... 300
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Chapter32:Structure andFunction oftheCardiovascular andLymphatic Systems ......................................... 311
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Chapter33:AlterationsofCardiovascular Function ...................................................................................... 324
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Chapter34:AlterationsofCardiovascular Function inChildren ...................................................................... 338
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Chapter35:StructureandFunctionofthePulmonary System....................................................................... 346
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Chapter 36: Alterations ofPulmonary Function ........................................................................................... 356
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Chapter37:Alterations ofPulmonaryFunctioninChildren ........................................................................... 373
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Chapter38:Structure andFunction oftheRenal andUrologic Systems .......................................................... 381
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Chapter 39: Alterations ofRenal and UrinaryTract Function ......................................................................... 391
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Chapter40:AlterationsofRenal andUrinaryTract Functionin Children .......................................................... 401
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Chapter41:StructureandFunctionoftheDigestive System.......................................................................... 409
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Chapter42:AlterationsofDigestive Function ............................................................................................... 421
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Chapter43:AlterationsofDigestive Function in Children .............................................................................. 432
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Chapter 44: Structure andFunction oftheMusculoskeletal System .............................................................. 441
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Chapter 45: AlterationsofMusculoskeletal Function ................................................................................... 453
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Chapter 46:AlterationsofMusculoskeletal Functionin Children ................................................................... 466
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Chapter47:Structure, Function, andDisordersoftheIntegument ................................................................. 475
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Chapter48:Alterationsofthe Integument in Children ................................................................................... 486
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Chapter49:Shock,Multiple OrganDysfunctionSyndrome, and Burnsin Adults .............................................. 494
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Chapter50:Shock,Multiple OrganDysfunctionSyndrome, and Burnsin Children........................................... 502
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, TestBank-Pathophysiology:TheBiologicBasisforDiseaseinAdultsandChildren(8th)
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Chapter01:CellularBiology P
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1. Whichstatementbestdescribes thecellularfunctionofmetabolicabsorption?
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a. Cellscanproduceproteins. Q
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b. Cellscansecretedigestiveenzymes. Q
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c. Cellscantakeinandusenutrients. Q
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d. Cellscansynthesizefats. Q
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ANS: C P Q
Inmetabolicabsorption,allcellstakeinandusenutrientsandothersubstancesfromtheir
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surroundings. The remainingoptions arenot inclusive in their descriptions of cellular
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metabolicabsorption.
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2. Whereismostofacell’sgeneticinformation,includingRNAandDNA,contained?
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a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome
ANS: C P Q
Thenucleuscontainsthenucleolus,asmalldensestructurecomposedlargelyofRNA,mostofthe cellular
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DNA,andtheDNA-bindingproteins, suchas thehistones, which regulate its activity.
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The mitochondria are responsible for cellular respiration and energyproduction.
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P Ribosomes’chieffunctionistoprovidesitesforcellularproteinsynthesis. Lysosomesfunctionas the
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intracellular digestive system.
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PTS: P Q P Q 1 DIF: CognitiveLevel: Remembering Q
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3. Whichcomponentofthecellproduceshydrogenperoxide(H2O2)byusingoxygento
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PQ removehydrogen atoms from specific substrates in an oxidative reaction? PQ PQ PQ PQ PQ PQ PQ PQ
a. Lysosomes
b. Peroxisomes
c. Ribosomes
d. Endosome
ANS: B P Q