STUDY GUIDE (270+ Q&A) ACCURATE EXPERT
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Terms in this set (270)
In the person with reactive C. ≥1 million mm3.
thrombocytosis, clotting risk
is typically absent until a Reactive thrombocytosis is an increase in platelet count in
platelet count of: response to a stimulus. There are several causes of reactive
thrombocytosis, including acute bleeding and blood loss,
a. ≥400,000 mm3
allergic reactions, cancer, infections, some types of anemia,
b. ≥800,000 mm3. major surgery, splenectomy, and some types of medications.
c. ≥1 million mm3. Treatment of reactive thrombocytosis is directed at the
d. ≥2 million mm3. underlying cause and platelet counts usually return to
normal once the underlying condition is brought under
control. An increased risk of blood clots can occur once the
platelet count is ≥1 million mm3 (NL = 150,000-450,000
mm3). Topic: Assessment and Intervention in Select
Hematologic Disorders
B. B-cell lymphocytes.
Antibodies are primarily
B cells are involved in antibody formation. Delaying the
formed by:
hypersensitivity response is a primary function of T-cell
a. T-cell lymphocytes.
lymphocytes. Granulocytes and monocytes are involved in
b. B-cell lymphocytes.
the phagocytosis of circulating debris and pathogens, such
c. Mast cells.
as bacteria or fungi. Topic:
d. Eosinophils.
Assessment and Intervention in Select Hematologic
Disorders
,Constitutional neutropenia is A. Those of African ancestry.
most often found in:
a. Those of Constitutional neutropenia (also called benign ethnic
Africanancestry. neutropenia or benign familial neutropenia) is a condition
more often observed in people with African and Middle
b. Sepsis recovery.
Eastern ancestry. The condition is potentially caused by a
c. Post transfusion defect in the release of mature WBCs from the bone
states. marrow to peripheral circulation. Despite a consistently
d. Patients who lower than normal ANC in people with constitutional
haveundergone neutropenia, many do not show increased susceptibility to
splenectomy. infection or any other adverse effect. Topic: Assessment and
Intervention in Select Hematologic Disorders
D. ANC < 500 mm3.
Agranulocytosis is Neutropenia is characterized by an absolute neutrophil
count (ANC) of <2000 mm3. Several factors can result in the
characterized by:
development of neutropenia, including a drug-induced
a. Total WBC ≤8000 mm3. reaction, nutritional deficiencies (e.g., vitamin B12, folate,
b. Total WBC ≤5000 mm3. or copper), and hormone disorders (e.g., thyrotoxicosis,
c. ANC < 2000 mm3 Addison disease, and acromegaly). Severe neutropenia, or
d. ANC < 500 mm3 agranulocytosis, is defined as an ANC <500 mm3 and places
the patient at increased susceptibility to serious bacterial
infections. Topic: Assessment and Intervention in Select
Hematologic Disorders.
,Eosinophilia is often seen in D. Protozoans.
infections caused by: a.
Viruses. Eosinophils exhibit weak phagocytic action in the presence of
b. Encapsulated bacteria. foreign substances and can ingest antigen-antibody complexes.
c. Mycobacterium. These cells are active against parasitic infections, such as
d. Protozoans. protozoans, and if the parasite is too large for ingestion, the
cells can release substances directly onto the parasite's
surface. Neutrophils are active against bacteria while
lymphocytes are active against viral infections. Topic:
Assessment and Intervention in Select Hematologic
Disorders
A WBC morphology D. Serious bacterial infection.
report relates toxic
granulation. This is most Toxic granulation refers to a morphology observed in
often seen in: granulocytes, such as neutrophils, that is characterized by
a. Pathogenic the presence of dark, coarse granules. This condition is
conditionsare caused by commonly observed in patients during inflammation or
intracellular organisms. acute infection. Granulocytes are involved in the
b. Viral illness. phagocytosis of bacterial or fungal pathogens and, thus,
c. Recovery stage toxic granulation is most likely a result of a serious bacterial
fromprotozoan infestation. d. infection. Topic: Assessment and Intervention in Select
Serious bacterial infection.
Hematologic Disorders
Which of the following is
consistent with
C. TWBC=10,100 mm3, 81% neuts.
neutrophilia?
a. TWBC=8,000 mm3,
Neutrophils are involved in the degradation of pathogens,
45%neuts
generation of oxidants, and tissue degradation. Neutrophilia
b. TWBC=13,500 mm3, can occur from acute infections and is characterized by an
35%neuts elevated number of neutrophils (>70% TWBC [NL=50%-70%
c. TWBC=10,100 mm3, TWBC in adults]). Leukocytosis with neutrophilia is
characterized by elevated levels of WBCs (NL = 6,000-10,000
81%neuts
per mm3 in adults). Topic: Assessment and Intervention in
d. TWBC=12,000 mm3, Select Hematologic Disorders
40%
neuts
, The use of which of the D. Unfractionated heparin.
following medications is a
common cause of Drug-induced thrombocytopenia is commonly caused by
druginduced accelerated platelet destruction by drugdependent, platelet-
thrombocytopenia? a. reactive antibodies. Medications associated with drug-induced
Warfarin thrombocytopenia include UF heparin, sulfonamides, thiazide
b. Aspirin diuretics, cimetidine, quinine, vancomycin, phenytoin,
c. Ibuprofen carbamazepine, beta-lactams, digoxin, and valproic acid. Upon
d. Unfractionated heparin discontinuation of the agent, an increase in platelet count
typically occurs within 2-7 days. Topic:
Assessment and Intervention in Select Hematologic
Disorders
Which of the following is B. Elevated MCV, normal MCHC.
most consistent with a
hemogram finding in vitamin Pernicious anemia is caused by a deficiency in vitamin B12
B12 deficiency that can which is needed for RBC production. The most common
occasionally be found with cause of pernicious anemia is an inability to absorb vitamin
long-term metformin use? B12 from food due to reduced production of intrinsic factors
a. Low MCV, elevated in the stomach but has also been attributed to long-term
MCHC metformin use in a dose-dependent manner. The
b. Elevated MCV, normal characteristics of vitamin B12 deficiency are an elevated
MCHC MCV with a normal MCHC. Treatment of pernicious anemia
c. Low MCV, low MCHC involves vitamin B12 replacement therapy. Topic:
d. Normal MCV, elevated Assessment and Intervention in Select Hematologic
MCHC Disorders