Pharmacokinetics I – Flashcards Questions And Answers

Pharmacokinetics I – Flashcards Questions
And Answers

Critical Thinking Intravenous drug administration bypasses drug absorption and
metabolism, Carrier proteins transport drugs based on their chemical characteristics



P-glycoprotein (P-gp) Active efflux pump for anticancer drugs, Member of ATP-binding
cassette (ABC) transporters



Organ distribution P-gp: Intestine, Liver, Kidney, Placenta, Blood-brain barrier (BBB),
Pancreas, Colon, Testis, BCRP: Intestine, Liver, Kidney, Placenta, BBB, Bronchi, MRP2:
Intestine, Liver, Kidney, Placenta, BBB, Mammary glands



Drug distribution Volume of distribution (Vd), Factors affecting drug distribution, Gut
transport, Liver metabolism, Cardiac output and blood flow, Physicochemical properties of
drugs, Plasma protein binding, Tissue binding and absorption/transport



Small Intestinal transporters Almost equal number of influx and efflux transporters in both
lumen and blood sides of the small intestine



Liver transporters More influx than efflux transporters in the blood side, but more efflux
than influx transporters in the bile side of the liver