NBME CBSE REAL EXAM 200 QUESTIONS AND i i i i i i i
ANSWERS LATEST 2023-2025 (usmle step 1)MEDICAL i i i i i
EXAMINATION LATEST UPDATES JUNE 2025 A GRADE. i i i i i i
70yo M dies in a motor vehicle collision. Was undergoing evaluation
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for occult blood in the stool. Photo of transverse colon shown. Dx? -
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ANSWER- Tubular adenoma i i
38yo M with 1-week hx of watery, itchy eyes and a runny nose. Physical
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shows inflamed nasal mucosa. No congestion in lower lung.
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Pharmacotherapy? - ANSWER- Loratadine i i i
16yo girl with 3-day hx of fever, nonproductive cough, and fatigue.
i i i i i i i i i i i
T 38.3, P 88/min, BP 102-70. PE shows pale conjunctivae. CXR
i i i i i i i i i i i
shows bilateral interstitial infiltrates. Blood spontaenously
i i i i i i
agglutinates while awaiting transport to the laboratory. Antibody
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isotypes causing
agglutination? - ANSWER- IgM i i i i
24yo M with small tender blisters on his penis 3 days after unprotected
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sex. Photograph shown. Causal agent? - ANSWER- HSV-2
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42yo F with 3-year hx of an intermittent facial rash, including the
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forehead, eyelids, nose, and cheeks. Rash seems to be getting worse
i i i i i i i i i i i
since she moved from New York to Florida last year. Spicy foods
i i i i i i i i i i i
,precipitate a flushing reaction that seems to exacerbate the rash. PE
i i i i i i i i i i i
shows erythema over the nose and cheeks, with scattered
i i i i i i i i i
telangiectasias and a few papules. Dx? - ANSWER- Rosacea i i i i i i i i
53yo M returned from Africa, has fever, headache, and abdominal
i i i i i i i i i
discomfort. Received appropriate vaccinations prior to the trip. T
i i i i i i i i i
39.4C.
A wright-stained peripheral smear shown. Dx? - ANSWER- Malaria
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68yo F with T2DM and hypertension that has been poorly controlled
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despite hydrochlorothiazide treatment. BP 150/96, Labs show serum
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glucose concentration of 130 and proteinuria. In addition to current x,
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which is most appropriate pharmacotherapy? - ANSWER- Lisinopril
i i i i i i i
66yo M with stage IV colon cancer with 3-day hx of severe diarrhea
i i i i i i i i i i i i i
after receiving chemotherapy with fluorouracil, leucovorin, and
i i i i i i i
Irinotecan. prescribed opioid antidiarrheal agent with no CNS effects.
i i i i i i i i i
Which med? - ANSWER- Loperamide
i i i i
,35yo M in ED with 2-hour hx of sever fatigue and dizziness. Had
i i i i i i i i i i i i i
profuse, watery diarrhea for 8 hours despite a lack of oral intake.
i i i i i i i i i i i i
Recently returned from a medical relief trip to a remove village in
i i i i i i i i i i i i
Honduras. T 36.7 C, P 122/min, BP 90/50. PE shows dry skin and
i i i i i i i i i i i i i
decreased capillary refill. Stool for occult blood is negative; stool is
i i i i i i i i i i i
gray and turbid. Gram stain shows gram-negative, comma-shaped
i i i i i i i i
bacteria; no erythrocytes of leukocytes. MOAof toxin? - ANSWER-
i i i i i i i i i i
Activation
of adenylyl cyclase
i i
59yo F with gradual onset of lack of muscle control in her left arm
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and leg. Sx 1 mo ago after dx with metastatic breast cancer. PE shows
i i i i i i i i i i i i i i
ataxia
of left upper and lower extremities. Muscle strength, DTR, sensation,
i i i i i i i i i i
cerebellum
proprioception normal. Metastatic tumor in which location? - ANSWER- i i i i i i i i
GRADE.
, Newborn delivered at 38 weeks' gestation weighs 1800 g. PE shows
i i i i i i i i i i i
petechial rash, microcephaly, and hepatosplenomegaly. Serologic test for
i i i i i i i i
CMV: IgG + in mother, + in newborn; IGM - in mother, + in newborn.
i i i i i i i i i i i i i i
Explanation? - ANSWER- Congenital cytomegalovirus infection i i i i i
Female newborn is delivered at 38 weeks' gestation. Apgar 8 and 8 at 1/5
i i i i i i i i i i i i i
min. PE shows a bulging, fluod0filled mass approximately 5 cm in
i i i i i i i i i i i
diameter in the midline over the lumbosacral region. No spontaneous
i i i i i i i i i i
movements of the lower extremities. Abnormality most likely i i i i i i i i
occurred because of abnormal development during which periods of
i i i i i i i i
postconception (in days)? - ANSWER- 15 to 40 i i i i i i i
64yo M in ED 3 hours after SOB with exertion and extreme fatigue.
i i i i i i i i i i i i i
Has ischemic heart disease. P 125/min, BP 105/60. ECG shows atrial
i i i i i i i i i i i
fibrillation. Intravenous ibutilide is administered. Ten minutes later, ECG
i i i i i i i i i
shows normal sinus rhythm. Risk for which drug effect in the next 6
i i i i i i i i i i i i i
hours? - ANSWER- torsades de pointes
i i i i i
65yo F with 20-year hx of osteoarthritis of the hands now has
i i i i i i i i i i i i
pain radiating down the distal anterior thigh, knee, medial leg, and
i i i i i i i i i i i
food. Bony outgrowth of vertebrae compressing one of the spinal
i i i i i i i i i i
nerves is suspected. Nerve root in which intervertebral foramina is
i i i i i i i i i i
effected? - ANSWER- L3 to L4 i i i i i
38yo M with 3-year hx of T2DM. Taking an oral antihyperglycemic
i i i i i i i i i i i
agent, he has tried diet and exercise. BMI 32. PE normal. Hb A1c is
i i i i i i i i i i i i i i
10%. Physician recommends initiation of insulin injections. Responds,
i i i i i i i i
"I know that insulin would help control my blood sugar. But a lot of
i i i i i i i i i i i i i i
people in my family have diabetes, and insulin made them really sick
i i i i i i i i i i i i
at times.
i
Patient is at which stage of change? -ANSWER- contemplation
24yo M with 2-day history of an itchy rash on his arms and legs.
i i i i i i i i i i i i i
ANSWERS LATEST 2023-2025 (usmle step 1)MEDICAL i i i i i
EXAMINATION LATEST UPDATES JUNE 2025 A GRADE. i i i i i i
70yo M dies in a motor vehicle collision. Was undergoing evaluation
i i i i i i i i i i i
for occult blood in the stool. Photo of transverse colon shown. Dx? -
i i i i i i i i i i i i i
ANSWER- Tubular adenoma i i
38yo M with 1-week hx of watery, itchy eyes and a runny nose. Physical
i i i i i i i i i i i i i i
shows inflamed nasal mucosa. No congestion in lower lung.
i i i i i i i i
Pharmacotherapy? - ANSWER- Loratadine i i i
16yo girl with 3-day hx of fever, nonproductive cough, and fatigue.
i i i i i i i i i i i
T 38.3, P 88/min, BP 102-70. PE shows pale conjunctivae. CXR
i i i i i i i i i i i
shows bilateral interstitial infiltrates. Blood spontaenously
i i i i i i
agglutinates while awaiting transport to the laboratory. Antibody
i i i i i i i i
isotypes causing
agglutination? - ANSWER- IgM i i i i
24yo M with small tender blisters on his penis 3 days after unprotected
i i i i i i i i i i i i
sex. Photograph shown. Causal agent? - ANSWER- HSV-2
i i i i i i i
42yo F with 3-year hx of an intermittent facial rash, including the
i i i i i i i i i i i i
forehead, eyelids, nose, and cheeks. Rash seems to be getting worse
i i i i i i i i i i i
since she moved from New York to Florida last year. Spicy foods
i i i i i i i i i i i
,precipitate a flushing reaction that seems to exacerbate the rash. PE
i i i i i i i i i i i
shows erythema over the nose and cheeks, with scattered
i i i i i i i i i
telangiectasias and a few papules. Dx? - ANSWER- Rosacea i i i i i i i i
53yo M returned from Africa, has fever, headache, and abdominal
i i i i i i i i i
discomfort. Received appropriate vaccinations prior to the trip. T
i i i i i i i i i
39.4C.
A wright-stained peripheral smear shown. Dx? - ANSWER- Malaria
i i i i i i i i
68yo F with T2DM and hypertension that has been poorly controlled
i i i i i i i i i i
despite hydrochlorothiazide treatment. BP 150/96, Labs show serum
i i i i i i i
glucose concentration of 130 and proteinuria. In addition to current x,
i i i i i i i i i
which is most appropriate pharmacotherapy? - ANSWER- Lisinopril
i i i i i i i
66yo M with stage IV colon cancer with 3-day hx of severe diarrhea
i i i i i i i i i i i i i
after receiving chemotherapy with fluorouracil, leucovorin, and
i i i i i i i
Irinotecan. prescribed opioid antidiarrheal agent with no CNS effects.
i i i i i i i i i
Which med? - ANSWER- Loperamide
i i i i
,35yo M in ED with 2-hour hx of sever fatigue and dizziness. Had
i i i i i i i i i i i i i
profuse, watery diarrhea for 8 hours despite a lack of oral intake.
i i i i i i i i i i i i
Recently returned from a medical relief trip to a remove village in
i i i i i i i i i i i i
Honduras. T 36.7 C, P 122/min, BP 90/50. PE shows dry skin and
i i i i i i i i i i i i i
decreased capillary refill. Stool for occult blood is negative; stool is
i i i i i i i i i i i
gray and turbid. Gram stain shows gram-negative, comma-shaped
i i i i i i i i
bacteria; no erythrocytes of leukocytes. MOAof toxin? - ANSWER-
i i i i i i i i i i
Activation
of adenylyl cyclase
i i
59yo F with gradual onset of lack of muscle control in her left arm
i i i i i i i i i i i i i i
and leg. Sx 1 mo ago after dx with metastatic breast cancer. PE shows
i i i i i i i i i i i i i i
ataxia
of left upper and lower extremities. Muscle strength, DTR, sensation,
i i i i i i i i i i
cerebellum
proprioception normal. Metastatic tumor in which location? - ANSWER- i i i i i i i i
GRADE.
, Newborn delivered at 38 weeks' gestation weighs 1800 g. PE shows
i i i i i i i i i i i
petechial rash, microcephaly, and hepatosplenomegaly. Serologic test for
i i i i i i i i
CMV: IgG + in mother, + in newborn; IGM - in mother, + in newborn.
i i i i i i i i i i i i i i
Explanation? - ANSWER- Congenital cytomegalovirus infection i i i i i
Female newborn is delivered at 38 weeks' gestation. Apgar 8 and 8 at 1/5
i i i i i i i i i i i i i
min. PE shows a bulging, fluod0filled mass approximately 5 cm in
i i i i i i i i i i i
diameter in the midline over the lumbosacral region. No spontaneous
i i i i i i i i i i
movements of the lower extremities. Abnormality most likely i i i i i i i i
occurred because of abnormal development during which periods of
i i i i i i i i
postconception (in days)? - ANSWER- 15 to 40 i i i i i i i
64yo M in ED 3 hours after SOB with exertion and extreme fatigue.
i i i i i i i i i i i i i
Has ischemic heart disease. P 125/min, BP 105/60. ECG shows atrial
i i i i i i i i i i i
fibrillation. Intravenous ibutilide is administered. Ten minutes later, ECG
i i i i i i i i i
shows normal sinus rhythm. Risk for which drug effect in the next 6
i i i i i i i i i i i i i
hours? - ANSWER- torsades de pointes
i i i i i
65yo F with 20-year hx of osteoarthritis of the hands now has
i i i i i i i i i i i i
pain radiating down the distal anterior thigh, knee, medial leg, and
i i i i i i i i i i i
food. Bony outgrowth of vertebrae compressing one of the spinal
i i i i i i i i i i
nerves is suspected. Nerve root in which intervertebral foramina is
i i i i i i i i i i
effected? - ANSWER- L3 to L4 i i i i i
38yo M with 3-year hx of T2DM. Taking an oral antihyperglycemic
i i i i i i i i i i i
agent, he has tried diet and exercise. BMI 32. PE normal. Hb A1c is
i i i i i i i i i i i i i i
10%. Physician recommends initiation of insulin injections. Responds,
i i i i i i i i
"I know that insulin would help control my blood sugar. But a lot of
i i i i i i i i i i i i i i
people in my family have diabetes, and insulin made them really sick
i i i i i i i i i i i i
at times.
i
Patient is at which stage of change? -ANSWER- contemplation
24yo M with 2-day history of an itchy rash on his arms and legs.
i i i i i i i i i i i i i