While rational drug selection is based on the individual patient the aspect of rational drug selection
addressing disease-specific information by a national medical or nursing organization is
A. a guideline.
B. cost.
C. availability.
D. patient hepatic and renal function. - Answers A. a guideline
Drugs that alter synaptic transmission are much more selective than those that alter axonal conduction,
why is this? - Answers a drug that affects the axonal conduction - non-selective effect.
Drugs that alter synaptic transmission - very selective because of the differences in synapses and their
specific neurotransmitters
What is phenytoin used for? - Answers Seizures
What should you monitor for with phenytoin? - Answers Delayed hypersensitivity - even 1 month later
What is carbamazepine used for? - Answers Seizures
What may cause carbamazepine levels to drop despite no other change? What to do? - Answers
Autometabolization of drug. Increase dose.
What is the black box warning for carbamazepine? - Answers Steven-Johnson Syndrome & TENS
Monitoring for carbamazepine, and how often? - Answers CBC, 3-4 times a year
What population is most at risk for Steven-Johnson syndrome & TENS when taking carbamazepine? -
Answers Asian patients
Main class of medication for depression? - Answers Selective serotonin reuptake inhibitors (SSRIs)
What to watch for with SSRIs? - Answers Other medications that can cause serotonin syndrome
What is lamictal used for? - Answers Seizures
Patient on lamictal has fever, rash, swollen lymph nodes. What are we concerned for? - Answers
Hypersensitivity in lamictal can lead to MODS
Patient on lamictal wants birth control. What do we need to change? - Answers Increase lamictal dose.
When will pt notice improvement after starting an SSRI? - Answers 4 weeks later
, 1st line medication for moderate generalized anxiety - Answers Buspar (SNRI)
1st line med for classic migraines - Answers Triptans
2nd line treatment for classic migraines - Answers Prophylactic - propranolol
Why is important that NPs have the authority to prescribe? - Answers Increase access to healthcare
What must be done if a drug has a narrow therapeutic index? - Answers Frequent serum level
monitoring
Why would 10mg percocet or 10mg oxy work better than the other? - Answers Differences in pill filler
composition
What do medications need in order to be effective: - Answers Albumin (binding to)
If a patient has a toxic drug level, but normal albumin, what could be happening? - Answers Other drugs
competing for albumin
What does "Sig" mean on a prescription? - Answers Directions to pharmacist
What items are necessary on a prescription? - Answers Drug, dose, route, frequency, quantity, refills
Abbreviations to not use - Answers QD
What drug may cause grey teeth? - Answers Tetracyclines
Pt reports no improvement in seizures after treatment for a few weeks. What next - Answers Assess
drug levels for therapeutic index
If patient on phenytoin wants birth control? - Answers Not oral contraceptives! IUD better
Patient on teratogen med wants to get pregnant. When should they stop? - Answers Before getting
pregnant, beware first trimester
Pregnant pt has been taking daily aspirin. Concern for what? - Answers Premature close of PFO
Pain treatment for shingles? - Answers Lidocaine after lesions heal
How does reglan help with GERD? - Answers Increases esophageal tone
Who should not take calcium carbonate antacids? - Answers Pt with kidney stones
Pt on minocycline with HA. Pt has what? - Answers Pseudotumor Cerebri
Why do we rotate off phentermine? - Answers Pt will develop tolerance
Education on flagyl? - Answers Avoid alcohol - severe reaction