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NR 546/NR546 FINAL STUDY GUIDE EXAM
LATEST VERSION WITH COMPLETE 500
QUESTIONS AND CORRECT ANSWERS JUST
RELEASED
Question: When voltage-sensitive sodium channels are open and activated, the flow of sodium
is:
A. Into the neuron
B. Out of the neuron - CORRECT ANSWER✔✔A. Into the neuron
Question: The alpha 2 delta subunit of voltage-sensitive calcium channels is believed to help
regulate opening and closing of the voltage sensitive calcium channel.
A. True
B. False - CORRECT ANSWER✔✔A. True
Question: A 22-year-old woman presents with schizophrenia characterized by the presence of
positive, negative, cognitive, and affective symptoms. The symptom dimension of schizophrenia
most effectively treated with antipsychotics is:
A. Positive symptoms
B. Negative symptoms
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C. Cognitive symptoms
D. Affective symptoms - CORRECT ANSWER✔✔A. Positive symptoms
Question: Symptoms of schizophrenia are hypothetically attributable to malfunctioning in the:
A. Mesolimbic and nigrostriatal pathways
B. Nigrostriatal and tuberoinfundibular pathways
C. Tuberoinfundibular and mesocortical pathways
D. Mesocortical and mesolimbic pathways - CORRECT ANSWER✔✔D. Mesocortical and
mesolimbic pathways
Question: The activation of N-methyl-d-aspartate (NMDA) receptors requires the presence of:
A. Glutamate only
B. Glutamate and glycine
C. Glutamate, glycine, and magnesium
D. Glutamate and magnesium - CORRECT ANSWER✔✔B. Glutamate and glycine
Question: A leading hypothesis of schizophrenia is:
A. Hyperfunctioning NMDA receptors
B. Hypofunctioning NMDA receptors - CORRECT ANSWER✔✔B. Hypofunctioning NMDA
receptors
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Question: The activation of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid)
receptors requires the presence of:
A. Glutamate only
B. Glutamate and glycine
C. Glutamate, glycine, and magnesium
D. None of the above - CORRECT ANSWER✔✔A. Glutamate only
Question: During cognitive challenges, individuals with schizophrenia demonstrate:
A. Hypoactivation in the DLPFC
B. Hyperactivation in the DLPFC
C. Normal activation in the DLPFC
D. A and B - CORRECT ANSWER✔✔D. A and B
Question: Conventional antipsychotics may worsen negative symptoms, presumably through
their actions in the:
A. Mesolimbic pathway
B. Mesolimbic and mesocortical pathways
C. Mesolimbic, mesocortial, and nigrostrital pathways - CORRECT ANSWER✔✔B. Mesolimbic
and mesocortical pathways
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Question: A 44-year-old male with schizophrenia has been taking an antipsychotic medication
since initial diagnosis twelve years ago. He has recently begun experiencing difficulty with fluid
movement of his arms as well as involuntary facial grimaces. Which of the following likely
underlies these symptoms?
A. Upregulation of serotonin 2A receptors
B. Downregulation of serotonin 2A receptors
C. Upregulation of dopamine 2 receptors
D. Downregulation of dopamine 2 receptors - CORRECT ANSWER✔✔C. Upregulation of
dopamine 2 receptors
Question: 38-year-old woman was diagnosed with schizophrenia approximately two years ago
and after multiple trials of different medications has been maintained on haloperidol for the last
several months with good response. Two weeks ago she began exhibiting mild motor symptoms
representative of parkinsonism. Which of the following would be the most appropriate adjunct
medication for this patient?
A. Alpha 1 adrenergic agonist
B. Cholinesterase inhibitor
C. Histamine 1 antagonist
D. Muscarinic 1 antagonist - CORRECT ANSWER✔✔D. Muscarinic 1 antagonist
NR 546/NR546 FINAL STUDY GUIDE EXAM
LATEST VERSION WITH COMPLETE 500
QUESTIONS AND CORRECT ANSWERS JUST
RELEASED
Question: When voltage-sensitive sodium channels are open and activated, the flow of sodium
is:
A. Into the neuron
B. Out of the neuron - CORRECT ANSWER✔✔A. Into the neuron
Question: The alpha 2 delta subunit of voltage-sensitive calcium channels is believed to help
regulate opening and closing of the voltage sensitive calcium channel.
A. True
B. False - CORRECT ANSWER✔✔A. True
Question: A 22-year-old woman presents with schizophrenia characterized by the presence of
positive, negative, cognitive, and affective symptoms. The symptom dimension of schizophrenia
most effectively treated with antipsychotics is:
A. Positive symptoms
B. Negative symptoms
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C. Cognitive symptoms
D. Affective symptoms - CORRECT ANSWER✔✔A. Positive symptoms
Question: Symptoms of schizophrenia are hypothetically attributable to malfunctioning in the:
A. Mesolimbic and nigrostriatal pathways
B. Nigrostriatal and tuberoinfundibular pathways
C. Tuberoinfundibular and mesocortical pathways
D. Mesocortical and mesolimbic pathways - CORRECT ANSWER✔✔D. Mesocortical and
mesolimbic pathways
Question: The activation of N-methyl-d-aspartate (NMDA) receptors requires the presence of:
A. Glutamate only
B. Glutamate and glycine
C. Glutamate, glycine, and magnesium
D. Glutamate and magnesium - CORRECT ANSWER✔✔B. Glutamate and glycine
Question: A leading hypothesis of schizophrenia is:
A. Hyperfunctioning NMDA receptors
B. Hypofunctioning NMDA receptors - CORRECT ANSWER✔✔B. Hypofunctioning NMDA
receptors
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Question: The activation of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid)
receptors requires the presence of:
A. Glutamate only
B. Glutamate and glycine
C. Glutamate, glycine, and magnesium
D. None of the above - CORRECT ANSWER✔✔A. Glutamate only
Question: During cognitive challenges, individuals with schizophrenia demonstrate:
A. Hypoactivation in the DLPFC
B. Hyperactivation in the DLPFC
C. Normal activation in the DLPFC
D. A and B - CORRECT ANSWER✔✔D. A and B
Question: Conventional antipsychotics may worsen negative symptoms, presumably through
their actions in the:
A. Mesolimbic pathway
B. Mesolimbic and mesocortical pathways
C. Mesolimbic, mesocortial, and nigrostrital pathways - CORRECT ANSWER✔✔B. Mesolimbic
and mesocortical pathways
, Page 4 of 145
Question: A 44-year-old male with schizophrenia has been taking an antipsychotic medication
since initial diagnosis twelve years ago. He has recently begun experiencing difficulty with fluid
movement of his arms as well as involuntary facial grimaces. Which of the following likely
underlies these symptoms?
A. Upregulation of serotonin 2A receptors
B. Downregulation of serotonin 2A receptors
C. Upregulation of dopamine 2 receptors
D. Downregulation of dopamine 2 receptors - CORRECT ANSWER✔✔C. Upregulation of
dopamine 2 receptors
Question: 38-year-old woman was diagnosed with schizophrenia approximately two years ago
and after multiple trials of different medications has been maintained on haloperidol for the last
several months with good response. Two weeks ago she began exhibiting mild motor symptoms
representative of parkinsonism. Which of the following would be the most appropriate adjunct
medication for this patient?
A. Alpha 1 adrenergic agonist
B. Cholinesterase inhibitor
C. Histamine 1 antagonist
D. Muscarinic 1 antagonist - CORRECT ANSWER✔✔D. Muscarinic 1 antagonist
