(Advanced Pharmacology for Care of the Family), Questions and Answers..docx

(Advanced Pharmacology for Care of the
Family), Questions and Answers.
Anti-Androgens - ANS >> Finasteride (Propecia) v v v v v


Leuprolide (Eligard, Lupron, Lupron Depot) v v v v


Spironolactone (Aldactone) v


Finasteride (Propecia, Proscar) - ANS >> blocks conversion of testosterone to
v v v v v v v v v v


dihydrotesterone
v




Used to tx: v v v


-BPH v


-male pattern baldness v v v


3 months of therapy need to see benefits
v v v v v v v v


Stopping, reverses effect w/in 12 months v v v v v




Adverse side effects: v v


- Decreased libido
v v v


-Impotence
dutasteride (Avodart) - ANS >> 5-alpha reductase inhibitor v v v v v v v


used to tx: v v


BPH v




Can stay in serum up to 6 mon after discontinuing
v v v v v v v v v




can be absorbed through skin
v v v v


pregnant woman shouldn't handle capsules v v v v


(fetal anomaly in male fetus)
v v v v




Adverse Effects v


decreased libido v v


Impotence
Leuprolide Acetate (Lupron) - ANS >> Luteinizing hormone - releasing agonist
v v v v v v v v v v v


create reversible: v


-orchiectomy state v


-oophorectomy state v
v


Used to tx: v v


- advanced prostatic cancer
v v v


- Management of endometriosis
v v v v


- Uterine fibroids
v v


- polycystic ovarian disease
v v v


- central precocious puberty in peds
v v v v v


Flutamide (Eulexin, Euflex) - ANS >> Truly non-steroidal agent
v v v v v v v v


Used to tx: v v


-Advanced prostate cancer v v

, -female androgen excess syndrome v v v v




Adverse Effects in males v v v


- gynecomastia
v


-reversible liver toxicity v v v




Black Box Warning v v


-hepatic failure v


-hepatic encephalopathy v v


Basline/monthly liver function test for 1st 4 months v v v v v v v


Spironolactone (Aldactone) - ANS >> aldosterone antagonist v v v v v v


potassium sparing diuretic v v v




used for tx: v v


-female hirsutism (abnormal growth of hair)
v v v v v


-acne v


-relief of PMS/PMDD symptoms (25-50 mg/d)
v v v v v




Adverse reactions v


- dose related + reversible when discont.
v v v v v v


-GI upsetv


-Drowsiness v


-Gynecomastia
-Impotence
-Cutaneous (skin) eruptions v v


- Urticaria
v v




Black Box Warning v v v


Tumorigenicity in animals v v v


Should not be used during pregnancy
v v v v v


Androgen - ANS >> Testosterone v v v v v


most important adrogen in humans
v v v v v


levels remain stable at 55yr
v v v v v


70 yrs men decrease in
v v v v v


-strength, libido, muscle mass v v v


Transdermal application of testosterone - ANS >> Patch + gel v v v v v v v v v


can be applied to intact nonscrotal skin
v v v v v v


once daily v


not for use in woman
v v v v


men cannot have skin contact with pregnant woman or children
v v v v v v v v v v


Men need to wash hands after application + allow skin to dry
v v v v v v v v v v v


Testopel - ANS >> Subcu Pellet v v v v v v


produces testosterone for 3-6 months v v v v


Contraindications for Testosterone - ANS >> Male breast cancer v v v v v v v v


prostate cancer v v


Pregnancy (X category) v v v