Understanding Opioid Tolerance and Its Effects
Questions and Answers/verified/latest update
Graded A+
Cross-tolerance - ✔✔Phenomenon where tolerance to one opioid agent results
in tolerance to others, but not to general CNS depressants.
Physical Dependence - ✔✔State where abrupt cessation of drug leads to
withdrawal symptoms due to adaptive cellular changes.
Abstinence Syndrome - ✔✔Symptoms following opioid withdrawal, intensity
and duration depend on drug half-life and physical dependence.
Half-life - ✔✔Time taken for the concentration of a drug in the body to reduce
by half.
Morphine - ✔✔An opioid with a relatively short half-life, leading to intense but
brief withdrawal symptoms.
Methadone - ✔✔An opioid with a long half-life, resulting in less intense but
prolonged withdrawal symptoms.
Withdrawal Symptoms - ✔✔Symptoms experienced when a person stops taking
opioids, intensity correlates with the degree of physical dependence.
Desond - ✔✔Likely a typo or unclear term, not defined in the notes.
Questions and Answers/verified/latest update
Graded A+
Cross-tolerance - ✔✔Phenomenon where tolerance to one opioid agent results
in tolerance to others, but not to general CNS depressants.
Physical Dependence - ✔✔State where abrupt cessation of drug leads to
withdrawal symptoms due to adaptive cellular changes.
Abstinence Syndrome - ✔✔Symptoms following opioid withdrawal, intensity
and duration depend on drug half-life and physical dependence.
Half-life - ✔✔Time taken for the concentration of a drug in the body to reduce
by half.
Morphine - ✔✔An opioid with a relatively short half-life, leading to intense but
brief withdrawal symptoms.
Methadone - ✔✔An opioid with a long half-life, resulting in less intense but
prolonged withdrawal symptoms.
Withdrawal Symptoms - ✔✔Symptoms experienced when a person stops taking
opioids, intensity correlates with the degree of physical dependence.
Desond - ✔✔Likely a typo or unclear term, not defined in the notes.
