CLINICAL MEDICINE EXAMS JANUARY 2020
What is haemostasis?[ - answer]Process by which bleeding from an injured vessel is arrested or reduced[
]what prevents platelet adhesion and thrombus formation?[ - answer]- thrombomodulin and heparan
sulphate expression
-endothelium
- synthesis of prostacyclin (prostaglandin I 2 , PGI 2 ) and nitric oxide (NO), which cause vasodilation and
inhibit platelet aggregation
- production of plasminogen activator[
]what mediated adherents between the escaping platelets and collagen and subendothelial bound VWF.[
- answer]glycoprotein Ib (GPIb)[
]what Does dense bodies release?[ - answer]adenosine diphosphate (ADP) and serotonin[
]α-granules contents[ - answer]platelet-derived growth factor, platelet factor 4, β-thromboglobulin,
fibrinogen, VWF, fibronectin, thrombospondin.[
]What activate platelets?[ - answer]fibrinogen[
]what makes the bridge between platelets?[ - answer]fibrinogen[
]what is the coagulation factor enzyme complexes[ - answer]tenase and prothrombinase[
]What does thrombin do?[ - answer]converts fibrinogen to fibrin, and encourages fusion of platelets[
]What does fibrin do?[ - answer]stabilizes clot[
, ]What does Thromboxane A2 (TXA2) do[ - answer]Made by platelets, PGH2--> TXA2 by thromboxane
synthase
Vasoconstrictor and enhance platelet aggregation, lowers cyclic adenosine monophosphate (AMP)
levels[
]What does Prostacyclin (PGI2) do[ - answer]Synthesized within vessel walls and inhibits
thrombogenesis[
]factors I and II are[ - answer]fibrinogen and prothrombin[
]The coagulation factors are primarily synthesized in[ - answer]liver[
]which factors are serine protease enzyme precursors[ - answer]factors IX, X and XI, and thrombin[
]which factors of the coagulation factors are co-factors[ - answer]factors V and VIII[
]fibrinogen is polymerized to form[ - answer]fibrin[
]factor I[ - answer]fibrinogen[
]factor II[ - answer]Prothrombin[
]factor III[ - answer]thromboplastin[
]factor IV[ - answer]calcium ions[
]factor V[ - answer]Proaccelerin, thrombin-activated[
]factor VII[ - answer]Proconvertin[
What is haemostasis?[ - answer]Process by which bleeding from an injured vessel is arrested or reduced[
]what prevents platelet adhesion and thrombus formation?[ - answer]- thrombomodulin and heparan
sulphate expression
-endothelium
- synthesis of prostacyclin (prostaglandin I 2 , PGI 2 ) and nitric oxide (NO), which cause vasodilation and
inhibit platelet aggregation
- production of plasminogen activator[
]what mediated adherents between the escaping platelets and collagen and subendothelial bound VWF.[
- answer]glycoprotein Ib (GPIb)[
]what Does dense bodies release?[ - answer]adenosine diphosphate (ADP) and serotonin[
]α-granules contents[ - answer]platelet-derived growth factor, platelet factor 4, β-thromboglobulin,
fibrinogen, VWF, fibronectin, thrombospondin.[
]What activate platelets?[ - answer]fibrinogen[
]what makes the bridge between platelets?[ - answer]fibrinogen[
]what is the coagulation factor enzyme complexes[ - answer]tenase and prothrombinase[
]What does thrombin do?[ - answer]converts fibrinogen to fibrin, and encourages fusion of platelets[
]What does fibrin do?[ - answer]stabilizes clot[
, ]What does Thromboxane A2 (TXA2) do[ - answer]Made by platelets, PGH2--> TXA2 by thromboxane
synthase
Vasoconstrictor and enhance platelet aggregation, lowers cyclic adenosine monophosphate (AMP)
levels[
]What does Prostacyclin (PGI2) do[ - answer]Synthesized within vessel walls and inhibits
thrombogenesis[
]factors I and II are[ - answer]fibrinogen and prothrombin[
]The coagulation factors are primarily synthesized in[ - answer]liver[
]which factors are serine protease enzyme precursors[ - answer]factors IX, X and XI, and thrombin[
]which factors of the coagulation factors are co-factors[ - answer]factors V and VIII[
]fibrinogen is polymerized to form[ - answer]fibrin[
]factor I[ - answer]fibrinogen[
]factor II[ - answer]Prothrombin[
]factor III[ - answer]thromboplastin[
]factor IV[ - answer]calcium ions[
]factor V[ - answer]Proaccelerin, thrombin-activated[
]factor VII[ - answer]Proconvertin[
