Maryville Pharm 615 Exam 2 Elle's Review
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1. Henry has recently started on carbamazepine to treat seizures. He comes to see you and you
note that while his carbamazepine levels had been in the therapeutic range they are now low. The
possible cause for the low carbamazepine levels include: - Answer✔Carbamazepine auto-
induces metabolism, leading to lower levels despite good compliance.
2. Carbamazepine has a Black Box Warning due to life-threatening: - Answer✔Dermatologic
reaction, including Steven's Johnson and toxic epidermal necrolysis
3. Long-term monitoring of patients who are taking carbamazepine includes: -
Answer✔Complete blood count every 3 to 4 months (can be a decrease in WBC & platelets)
Six-year-old Felisha has recently been started on ethosuximide (Zarontin) for seizures. She
should be monitored for: - Answer✔Blood dyscrasias, which are uncommon but possible
What should families be taught regarding seizure activity monitoring? - Answer✔Prevention of
seizures, patient safety, quality of life issues, reach acceptable goals for treatment, & do not
abruptly stop taking seizure meds
What electrolyte imbalance is associated with topiramate? - Answer✔Decreased sodium bicarb
leading to hyperchloremic metabolic acidosis
Lisa who is overweight recently started taking topiramate for seizures and at her follow-up visit
you note she has lost 4 kg. The appropriate action would be: - Answer✔Reassure her that this is
a normal side effect of topiramate and continue to monitor her weight.
Travis's seizures are well controlled on topiramate and he wants to start playing baseball.
Education for Travis regarding his topiramate includes: - Answer✔He should monitor his
temperature and ability to sweat in the heat while playing
9. Brandy is taking valproate (Depakote) for seizures and would like to get pregnant. What
advice would you give her? - Answer✔Valproate is a known teratogen, but may be taken after
the first trimester if necessary. Keppra is a better drug to be on until the second trimester, then
she can go back to valproate.
10. What category is valproate? - Answer✔Category X
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11. The tricyclic antidepressants should be prescribed cautiously in patients with: -
Answer✔Heart disease
12. A 64-year-old male was prescribed phenelzine (Nardil) while in an acute psychiatric unit for
recalcitrant depression. The NP managing his primary health care needs to understand the
following regarding phenelzine and other monoamine oxidase inhibitors (MAOIs): -
Answer✔He should not be prescribed any serotonergic drug such as sumatriptan (Imitrex),
MAOIs interact with many common foods, including yogurt, sour cream, and soy sauce, and
symptoms of hypertensive crisis (headache, tachycardia, sweating) require immediate treatment
13. What are the precautions and contraindications for tricyclic antidepressants? - Answer✔Side
effects are similar to anticholinergic activity such as dry mouth, sedation, constipation, increased
appetite, blurred vision, tinnitus, euphoria, and mania. Caution in patients with cardiac disease
(terminate ventricular fibrillation, decrease cardiac contractility, increase collateral blood
circulation to ischemic heart muscles).
14. Marla is started on paroxetine (Paxil) a selective serotonin reuptake inhibitor (SSRI) -
Answer✔for depression. Education regarding her antidepressant includes:,SSRIs may take 2 to 6
weeks before she will have maximum drug effects.
15. What "onset of action" symptoms should be reviewed with patients who have been newly
prescribed a selective serotonin reuptake inhibitor? - Answer✔They can feel a bit of nausea, but
this resolves in a week.
16. Which of the following should not be taken with a selective serotonin reuptake inhibitor? -
Answer✔Alcohol
17. Why is the consistency of taking paroxetine (Paxil) and never running out of medication
more important than with most other selective serotonin reuptake inhibitors (SSRIs)? -
Answer✔It has a shorter half-life and withdrawal syndrome has a faster onset without taper
18. Janet presents with depression associated with complaints of fatigue sleeping all the time and
lack of motivation. An appropriate initial antidepressant for her would be: - Answer✔Duloxetine
(Cymbalta)
19. A patient with anxiety and depression may respond to: - Answer✔Buspirone (Buspar) and an
SSRI combined
20. When is buspirone (Buspar) and an SSRI combined? - Answer✔Buspar is helpful in
augmenting the SSRI and in treating patients with agitated or anxious depression
21. An appropriate first-line drug to try for mild to moderate generalized anxiety disorder would
be: - Answer✔Buspirone (Buspar)
22. Larry has been prescribed citalopram (Celexa) to treat his depression. Education regarding
how quickly selective serotonin reuptake inhibitor (SSRI) antidepressants work would be: -
Answer✔Appetite and concentration improve in the first 1 to 2 weeks
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