QBM Final Exam Practice questions with verified
answers
Which of the following is LEAST suited to analyze titin, a large protein? Ans✓✓-
MS
Bioinformatics Ans✓✓-All answer choices are correct.
In flow cytometry, the forward scattering of light can indicate __________, and
the side scatter indicates __________. Ans✓✓-the size of a cell; the cell's
granularity, or health.
Mass spectrometers can have some variation in peak shape due to Ans✓✓-
isotopes.
__________ can be used for the resolution of individual atoms. This is performed
by __________. Ans✓✓-Cryo-EM; many copies of the sample are frozen and
placed under an electron microscope.
A knockin mouse Ans✓✓-has a gene insertion.
Which of the following techniques would be best suited to directly study cellular
metabolism in vitro? Ans✓✓-ExPASy
Sequence analysis Ans✓✓-All answer choices are correct.
BLAST stands for Ans✓✓-Basic Local Alignment Search Tool.
, Which of the following best describes the Cre-Lox system? Ans✓✓-A transgenic
mouse that knocks out a target gene only in a specific cell type, by utilizing gene
inversion.
A __________ can be used to predict the secondary structures of proteins.
Ans✓✓-Ramachandran plot
The final step of X-ray crystallography is to Ans✓✓-calculate an electron density
map.
Which of the following best describes shotgun sequencing? Ans✓✓-Genome is
sheared, ligated into plasmids via TA cloning, sequenced with primers, and pieced
together on a computer.
Genome is sheared, ligated into plasmids via TA cloning, sequenced with primers,
and pieced together on a computer. Ans✓✓-Circular dichroism
What is the benefit of using knockdown mice instead of knockout mice? Ans✓✓-
The mutation may be embryonic lethal; knockdown would allow to still assess the
effects of the gene.
Which of the following either can be performed now or may be possible in the
future using CRISPR? Ans✓✓-All answer choices are correct.
Which of the following is NOT a feature of drug design? Ans✓✓-Structure-based
drug design exhibits an increase in false positives compared to high-throughput
screening.
answers
Which of the following is LEAST suited to analyze titin, a large protein? Ans✓✓-
MS
Bioinformatics Ans✓✓-All answer choices are correct.
In flow cytometry, the forward scattering of light can indicate __________, and
the side scatter indicates __________. Ans✓✓-the size of a cell; the cell's
granularity, or health.
Mass spectrometers can have some variation in peak shape due to Ans✓✓-
isotopes.
__________ can be used for the resolution of individual atoms. This is performed
by __________. Ans✓✓-Cryo-EM; many copies of the sample are frozen and
placed under an electron microscope.
A knockin mouse Ans✓✓-has a gene insertion.
Which of the following techniques would be best suited to directly study cellular
metabolism in vitro? Ans✓✓-ExPASy
Sequence analysis Ans✓✓-All answer choices are correct.
BLAST stands for Ans✓✓-Basic Local Alignment Search Tool.
, Which of the following best describes the Cre-Lox system? Ans✓✓-A transgenic
mouse that knocks out a target gene only in a specific cell type, by utilizing gene
inversion.
A __________ can be used to predict the secondary structures of proteins.
Ans✓✓-Ramachandran plot
The final step of X-ray crystallography is to Ans✓✓-calculate an electron density
map.
Which of the following best describes shotgun sequencing? Ans✓✓-Genome is
sheared, ligated into plasmids via TA cloning, sequenced with primers, and pieced
together on a computer.
Genome is sheared, ligated into plasmids via TA cloning, sequenced with primers,
and pieced together on a computer. Ans✓✓-Circular dichroism
What is the benefit of using knockdown mice instead of knockout mice? Ans✓✓-
The mutation may be embryonic lethal; knockdown would allow to still assess the
effects of the gene.
Which of the following either can be performed now or may be possible in the
future using CRISPR? Ans✓✓-All answer choices are correct.
Which of the following is NOT a feature of drug design? Ans✓✓-Structure-based
drug design exhibits an increase in false positives compared to high-throughput
screening.
