Advanced pathophysiology exam
Advanced pathophysiology exam
based question and correct answers
only
An Ordered Photographic Display Of A Set Of Chromosomes From A Single Cell Is A
A) Metaphase Spread.
B) Autosomal Spread.
C) Karyotype.
D) Anaphase Spread. - ✔✔✔C
A 50-Year-Old Male Was Recently Diagnosed With Huntington Disease. Transmission Of This Disease Is
Associated With:
A) Penetrance.
B) Recurrence Risk.
C) Expressivity.
D) Delayed Age Of Onset. - ✔✔✔D
People Who Have Neurofibromatosis Will Show Varying Degrees Of The Disease; This Is Because Of The
Genetic Principle Of:
pg. 1
, Advanced pathophysiology exam
A) Penetrance.
B) Expressivity.
C) Dominance.
D) Recessiveness. - ✔✔✔B
Cystic Fibrosis Is Caused By An _____ Gene.
A) X-Linked Dominant
B) X-Linked Recessive
C) Autosomal Dominant
D) Autosomal Recessive - ✔✔✔D
To Express A Polygenic Trait:
A) Genes Must Interact With The Environment.
B) Several Genes Must Act Together.
C) Multiple Mutations Must Occur In The Same Family.
D) In Situ Cloning Must Occur. - ✔✔✔B
The Gradual Increase In Height Among The Human Population Over The Past 100 Years Is An Example
Of:
A) Polygenic Trait.
B) Multifactorial Trait.
C) Crossing Over.
D) Recombination. - ✔✔✔B
A Couple Has Three Offspring: One Child With An Autosomal Dominant Disease Trait And Two Who Are
Normal. The Father Is Affected By The Autosomal Dominant Disease, But The Mother Does Not Have The
Disease Gene. What Is The Recurrence Risk Of This Autosomal Dominant Disease For Their Next Child?
A) 50%
B) 33%
pg. 2
, Advanced pathophysiology exam
C) 25%
D) Impossible To Determine - ✔✔✔A
A 12-Year-Old Male Is Diagnosed With Klinefelter Syndrome. His Karyotype Would Reveal Which Of The
Following?
A) XY
B) XX
C) XYY
D) XXY - ✔✔✔D
A 5-Year-Old Male Presents With Mental Retardation And Is Diagnosed With Fragile X Syndrome. Which
Of The Following Is Most Likely To Cause This Syndrome?
A) Translocation
B) Inversion
C) Nondisjunction
D) Duplication At Fragile Sites - ✔✔✔D
The Outward Manifestation Of A Disease, Often Influenced By Both Genes And The Environment, Is
Called The Disease:
A) Genotype.
B) Allele.
C) Phenotype.
D) Dominance. - ✔✔✔C
Which Of The Following Genetic Diseases Manifests With Progressive Dementia In Middle To Later
Adulthood?
A) Duchenne Muscular Dystrophy
B) Cystic Fibrosis
C) Achondroplasia
D) Huntington Disease - ✔✔✔D
pg. 3
, Advanced pathophysiology exam
Which Of The Following Types Of Genetic Disorders Is The Most Common Cause Of Miscarriage?
A) Autosomal Dominant
B) Autosomal Recessive
C) X-Linked Recessive
D) Chromosomal - ✔✔✔D
An Error In Which Homologous Chromosomes Fail To Separate During Meiosis Is Termed:
A) Aneuploidy.
B) Nondisjunction.
C) Polyploidy.
D) Anaplasia. - ✔✔✔B
A Somatic Cell That Does Not Contain A Multiple Of 23 Chromosomes Is Called:
A) An Aneuploid Cell.
B) A Euploid Cell.
C) A Polyploidy Cell.
D) A Haploid Cell. - ✔✔✔A
A 20-Year-Old Pregnant Female Gives Birth To A Stillborn Child. Autopsy Reveals That The Fetus Has 92
Chromosomes. Which Of The Following Describes This Condition?
A) Euploidy
B) Triploidy
C) Tetraploidy
D) Aneuploidy - ✔✔✔C
If A Person Is A Chromosomal Mosaic, The Person May:
A) Be A Carrier Of The Genetic Disease.
B) Have A Mild Form Of The Genetic Disease.
pg. 4
Advanced pathophysiology exam
based question and correct answers
only
An Ordered Photographic Display Of A Set Of Chromosomes From A Single Cell Is A
A) Metaphase Spread.
B) Autosomal Spread.
C) Karyotype.
D) Anaphase Spread. - ✔✔✔C
A 50-Year-Old Male Was Recently Diagnosed With Huntington Disease. Transmission Of This Disease Is
Associated With:
A) Penetrance.
B) Recurrence Risk.
C) Expressivity.
D) Delayed Age Of Onset. - ✔✔✔D
People Who Have Neurofibromatosis Will Show Varying Degrees Of The Disease; This Is Because Of The
Genetic Principle Of:
pg. 1
, Advanced pathophysiology exam
A) Penetrance.
B) Expressivity.
C) Dominance.
D) Recessiveness. - ✔✔✔B
Cystic Fibrosis Is Caused By An _____ Gene.
A) X-Linked Dominant
B) X-Linked Recessive
C) Autosomal Dominant
D) Autosomal Recessive - ✔✔✔D
To Express A Polygenic Trait:
A) Genes Must Interact With The Environment.
B) Several Genes Must Act Together.
C) Multiple Mutations Must Occur In The Same Family.
D) In Situ Cloning Must Occur. - ✔✔✔B
The Gradual Increase In Height Among The Human Population Over The Past 100 Years Is An Example
Of:
A) Polygenic Trait.
B) Multifactorial Trait.
C) Crossing Over.
D) Recombination. - ✔✔✔B
A Couple Has Three Offspring: One Child With An Autosomal Dominant Disease Trait And Two Who Are
Normal. The Father Is Affected By The Autosomal Dominant Disease, But The Mother Does Not Have The
Disease Gene. What Is The Recurrence Risk Of This Autosomal Dominant Disease For Their Next Child?
A) 50%
B) 33%
pg. 2
, Advanced pathophysiology exam
C) 25%
D) Impossible To Determine - ✔✔✔A
A 12-Year-Old Male Is Diagnosed With Klinefelter Syndrome. His Karyotype Would Reveal Which Of The
Following?
A) XY
B) XX
C) XYY
D) XXY - ✔✔✔D
A 5-Year-Old Male Presents With Mental Retardation And Is Diagnosed With Fragile X Syndrome. Which
Of The Following Is Most Likely To Cause This Syndrome?
A) Translocation
B) Inversion
C) Nondisjunction
D) Duplication At Fragile Sites - ✔✔✔D
The Outward Manifestation Of A Disease, Often Influenced By Both Genes And The Environment, Is
Called The Disease:
A) Genotype.
B) Allele.
C) Phenotype.
D) Dominance. - ✔✔✔C
Which Of The Following Genetic Diseases Manifests With Progressive Dementia In Middle To Later
Adulthood?
A) Duchenne Muscular Dystrophy
B) Cystic Fibrosis
C) Achondroplasia
D) Huntington Disease - ✔✔✔D
pg. 3
, Advanced pathophysiology exam
Which Of The Following Types Of Genetic Disorders Is The Most Common Cause Of Miscarriage?
A) Autosomal Dominant
B) Autosomal Recessive
C) X-Linked Recessive
D) Chromosomal - ✔✔✔D
An Error In Which Homologous Chromosomes Fail To Separate During Meiosis Is Termed:
A) Aneuploidy.
B) Nondisjunction.
C) Polyploidy.
D) Anaplasia. - ✔✔✔B
A Somatic Cell That Does Not Contain A Multiple Of 23 Chromosomes Is Called:
A) An Aneuploid Cell.
B) A Euploid Cell.
C) A Polyploidy Cell.
D) A Haploid Cell. - ✔✔✔A
A 20-Year-Old Pregnant Female Gives Birth To A Stillborn Child. Autopsy Reveals That The Fetus Has 92
Chromosomes. Which Of The Following Describes This Condition?
A) Euploidy
B) Triploidy
C) Tetraploidy
D) Aneuploidy - ✔✔✔C
If A Person Is A Chromosomal Mosaic, The Person May:
A) Be A Carrier Of The Genetic Disease.
B) Have A Mild Form Of The Genetic Disease.
pg. 4
