Practice Questions
Charlie is a 65-year-old male who has been diagnosed with hypertension and benign prostatic
hyperplasia. Doxazosin has been chosen to treat his hypertension because it:
a.dIncreasesdperipheraldvasoconstriction
b.dDecreasesddetrusordmuscledcontractility
c.dLowersdsupinedblooddpressuredmoredthandstandingdpressure
d.dRelaxesdsmoothdmuscledindthedbladderdneckd-
dANSWERdd.dRelaxesdsmoothdmuscledindthedbladderdneck
Todreducedpotentialdadversedeffects,dpatientsdtakingdadperipherallydactingdalpha1dantagonistdshouldd
dodalldofdthedfollowingdEXCEPT:
1.dTakedtheddosedatdbedtime
2.dSitdupdslowlydandddangledtheirdfeetdbeforedstanding
3.dMonitordtheirdblooddpressuredanddskipdaddosedifdthedpressuredisdlessdthand120/80
4.dWeighddailydanddreportdweightdgaindofdgreaterdthand2dpoundsdindoneddayd-
dANSWERd3.dMonitordtheirdblooddpressuredanddskipdaddosedifdthedpressuredisdlessdthand120/80
Johndhasdclonidine,dadcentrallydactingdadrenergicdblocker,dprescribeddfordhisdhypertension.dHedshould
:
1.dNotdmissdaddosedordstopdtakingdtheddrugdbecausedofdpotentialdrebounddhypertension
2.dIncreasedfiberdindtheddietdtodtreatdanyddiarrheadthatdmaydoccur
3.dReducedfluiddintakedtodlessdthand2dlitersdperddaydtodpreventdfluiddretention
4.dAvoiddsittingdfordlongdperiods,dasdthisdcandleaddtoddeepdveindthrombosisd-
dANSWERd1.dNotdmissdaddosedordstopdtakingdtheddrugdbecausedofdpotentialdrebounddhypertension
,Clonidinedhasdseveraldoff-labelduses,dincluding:
1.dAlcoholdanddnicotinedwithdrawal
2.dPost-herpeticdneuralgia
3.dBothd1dandd2
4.dNeitherd1dnord2d-dANSWERd3.dBothd1dandd2
Jimdisdbeingdtreateddfordhypertension.dBecausedhedhasdadhistorydofdheartdattack,dtheddrugdchosendisd
atenolol.dBetadblockersdtreatdhypertensiondby:
1.dIncreasingdheartdratedtodimprovedcardiacdoutput
2.dReducingdvasculardsmoothdmuscledtone
3.dIncreasingdaldosterone-mediateddvolumedactivity
4.dReducingdaqueousdhumordproductiond-dANSWERd2.dReducingdvasculardsmoothdmuscledtone
6.dWhichdofdthedfollowingdadversedeffectsdaredlessdlikelydindadbetad1-selectivedblocker?
1.dDysrhythmias
2.dImpaireddinsulindrelease
3.dReflexdorthostaticdchanges
4.dDecreaseddtriglyceridesdanddcholesterold-dANSWERd2.dImpaireddinsulindrelease
Richarddisd70dyearsdolddanddhasdadhistorydofdcardiacddysrhythmias.dHedhasdbeendprescribeddnadolol.d
YouddodhisdannualdlaboratorydworkdanddfinddadCrCldofd25dml/
min.dWhatdactiondshoulddyoudtakedrelateddtodhisdnadolol?
1.dExtenddtheddosagedinterval.
2.dDecreasedtheddosedbyd75%.
3.dTakednodactiondbecausedthisdvaluedisdexpecteddindthedolderdadult.
,4.dScheduledadserumdcreatininedleveldtodvalidatedthedCrCldvalue.d-
dANSWERd1.dExtenddtheddosagedinterval.
Betadblockersdaredtheddrugsdofdchoicedfordexertionaldanginadbecausedthey:
1.dImprovedmyocardialdoxygendsupplydbydvasodilatingdthedcoronarydarteries
2.dDecreasedmyocardialdoxygenddemanddbyddecreasingdheartdratedanddvasculardresistance
3.dBothd1dandd2
4.dNeitherd1dnord2d-
dANSWERd2.dDecreasedmyocardialdoxygenddemanddbyddecreasingdheartdratedanddvasculardresistance
Adherencedtodbetadblockerdtherapydmaydbedaffecteddbydtheir:
1.dShortdhalf-livesdrequiringdtwiceddailyddosing
2.dTendencydtodelevatedlipiddlevels
3.dEffectsdondthedmaledgenitalia,dwhichdmaydproducedimpotence
4.dNonedofdthedaboved-dANSWERd3.dEffectsdondthedmaledgenitalia,dwhichdmaydproducedimpotence
Betadblockersdhavedfavorabledeffectsdondsurvivaldandddiseasedprogressiondindheartdfailure.dTreatment
dshoulddbedinitiateddwhendthe:
1.dSymptomsdaredsevere
2.dPatientdhasdnotdrespondeddtodotherdtherapies
3.dPatientdhasdconcurrentdhypertension
4.dLeftdventricularddysfunctiondisddiagnosedd-dANSWERd4.dLeftdventricularddysfunctiondisddiagnosed
Abruptdwithdrawaldofdbetadblockersdcandbedlifedthreatening.dPatientsdatdhighestdriskdfordseriousdcons
equencesdofdrapiddwithdrawaldaredthosedwith:
1.Angina
2.Coronarydarteryddisease
, 3.Bothd1dandd2
4.Neitherd1dnord2d-dANSWERd3.Bothd1dandd2
Todpreventdlife-threateningdeventsdfromdrapiddwithdrawaldofdadbetadblocker:
1.dTheddosagedintervaldshoulddbedincreaseddbyd1dhourdeachdday.
2.dAndalphadblockerdshoulddbedaddeddtodthedtreatmentdregimendbeforedwithdrawal.
3.dTheddosagedshoulddbedtapereddoverdadperioddofdweeks.
4.dTheddosagedshoulddbeddecreaseddbydone-halfdeveryd4ddays.d-
dANSWERd4.dTheddosagedshoulddbeddecreaseddbydone-halfdeveryd4ddays.
Betadblockersdaredprescribeddforddiabeticsdwithdcautiondbecausedofdtheirdabilitydtodproducedhypoglyc
emiadanddblockdthedcommondsymptomsdofdit.dWhichdofdthedfollowingdsymptomsdofdhypoglycemiadisd
notdblockeddbydtheseddrugsdanddsodcandbeduseddtodwarnddiabeticsdofdpossibleddecreaseddblooddgluc
ose?
1.dDizziness
2.dIncreaseddheartdrate
3.dNervousnessdanddshakiness
4.dDiaphoresisd-dANSWERd4.dDiaphoresis
Combineddalpha-betadantagonistsdareduseddtodreducedthedprogressiondofdheartdfailuredbecausedthey:
1.dVasodilatedthedperipheraldvasculature
2.dDecreasedcardiacdoutput
3.dIncreasedrenaldvasculardresistance
4.dReducedatherosclerosisdsecondarydtodelevateddserumdlipoproteinsd-
dANSWERd1.dVasodilatedthedperipheraldvasculature
CarvediloldisdheavilydmetabolizeddbydCYP2D6dandd2C9,dresultingdinddrugdinteractionsdwithdwhichdofdt
hedfollowingddrugdclasses?