TEST BANK
, Chapter 1: Principles of Pharmacology
Multiple Choice
1. refer(s) to specific molecular changes that occur when a drug binds to a
particular target site or receptor, while are the resulting widespread alterations
in function.
a. Drug action; therapeutic effects
b. Side effects; drug effects
c. Therapeutic effects; side effects
d. Drug action; drug effects
Answer: d
Textbook Reference: Pharmacology: The Science of Drug Action
2. After drug administration has occurred, the amount of drug in the blood that is free to
bind at specific target sites is referred to as
a. the therapeutic dose.
b. first-pass effects.
c. bioavailability.
d. ED50.
Answer: c
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
3. The specific molecular changes that occur when a drug binds to a particular target site
or receptor are referred to as
a. drug effects.
b. drug action.
c. side effects.
d. placebo effects.
Answer: b
Textbook Reference: Pharmacology: The Science of Drug Action
4. Which of the following is not a possible explanation for placebo effects?
a. Pavlovian conditioning
b. Genetic variation
c. Drug competition
d. Expectation of outcome
Answer: c
Textbook Reference: Pharmacology: The Science of Drug Action
Page 1 of 247
,5. The administration of oxytocin has been proposed as a treatment for autism.
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
6. Which factor does not affect the pharmacokinetics of a drug?
a. Route of administration
b. Lipid solubility
c. Depot binding
d. Drug action
Answer: d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
7. First-pass metabolism occurs when drugs are taken
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
8. The area postrema is one area in the brain where the is not complete.
a. cerebrospinal fluid
b. blood–brain barrier
c. choroid plexus
d. phospholipid membrane
Answer: b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
9. First-pass metabolism occurs with orally administered drugs because
a. their absorption is slowed by food.
b. drugs absorbed into the bloodstream from the stomach go to the liver on the way to
general circulation.
c. drugs must first survive the acidic environment of the stomach.
d. salivary enzymes in the mouth begin the process of metabolism.
Answer: b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
10. Toxic substances in the blood trigger a vomiting response by activating the
a. blood–brain barrier.
b. choroid plexus.
c. area postrema.
d. median eminence.
Page 2 of 247
, Answer: c
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
11. Drugs administered _ have the most rapid onset of action.
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
12. Ionization of a drug depends on the of the solution and the of the
drug.
a. pH; pKa
b. pKa; pH
c. concentration; lipid solubility
d. pH; concentration
Answer: a
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
13. The iabsorption iof ia idrug idepends ion iall iof ithe ifollowing iexcept
a. lipid isolubility.
b. ionization.
c. body itemperature.
d. the iconcentration iof ithe idrug.
Answer: ic
Textbook iReference: iPharmacokinetic iFactors iDetermining iDrug iAction
14. Drugs ithat iare should ibe iavoided iby iwomen iof ichildbearing iage.
a. teratogenic
b. able ito icross ithe iplacental ibarrier
c. psychoactive
d. highly ilipid-soluble
Answer: ia
Textbook iReference: iPharmacokinetic iFactors iDetermining iDrug iAction
15. Agents ithat iinduce idevelopmental iabnormalities iin ia ifetus iare iknown ias
a. psychoactive idrugs.
b. illicit idrugs.
c. teratogens.
d. placental idrugs.
Answer: ic
Textbook iReference: iPharmacokinetic iFactors iDetermining iDrug iAction
16. Depot ibinding iis isaid ito ioccur iwhen idrugs
a. bind ito itheir itarget isites.
Page 3 of 247
, Chapter 1: Principles of Pharmacology
Multiple Choice
1. refer(s) to specific molecular changes that occur when a drug binds to a
particular target site or receptor, while are the resulting widespread alterations
in function.
a. Drug action; therapeutic effects
b. Side effects; drug effects
c. Therapeutic effects; side effects
d. Drug action; drug effects
Answer: d
Textbook Reference: Pharmacology: The Science of Drug Action
2. After drug administration has occurred, the amount of drug in the blood that is free to
bind at specific target sites is referred to as
a. the therapeutic dose.
b. first-pass effects.
c. bioavailability.
d. ED50.
Answer: c
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
3. The specific molecular changes that occur when a drug binds to a particular target site
or receptor are referred to as
a. drug effects.
b. drug action.
c. side effects.
d. placebo effects.
Answer: b
Textbook Reference: Pharmacology: The Science of Drug Action
4. Which of the following is not a possible explanation for placebo effects?
a. Pavlovian conditioning
b. Genetic variation
c. Drug competition
d. Expectation of outcome
Answer: c
Textbook Reference: Pharmacology: The Science of Drug Action
Page 1 of 247
,5. The administration of oxytocin has been proposed as a treatment for autism.
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
6. Which factor does not affect the pharmacokinetics of a drug?
a. Route of administration
b. Lipid solubility
c. Depot binding
d. Drug action
Answer: d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
7. First-pass metabolism occurs when drugs are taken
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
8. The area postrema is one area in the brain where the is not complete.
a. cerebrospinal fluid
b. blood–brain barrier
c. choroid plexus
d. phospholipid membrane
Answer: b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
9. First-pass metabolism occurs with orally administered drugs because
a. their absorption is slowed by food.
b. drugs absorbed into the bloodstream from the stomach go to the liver on the way to
general circulation.
c. drugs must first survive the acidic environment of the stomach.
d. salivary enzymes in the mouth begin the process of metabolism.
Answer: b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
10. Toxic substances in the blood trigger a vomiting response by activating the
a. blood–brain barrier.
b. choroid plexus.
c. area postrema.
d. median eminence.
Page 2 of 247
, Answer: c
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
11. Drugs administered _ have the most rapid onset of action.
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
12. Ionization of a drug depends on the of the solution and the of the
drug.
a. pH; pKa
b. pKa; pH
c. concentration; lipid solubility
d. pH; concentration
Answer: a
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
13. The iabsorption iof ia idrug idepends ion iall iof ithe ifollowing iexcept
a. lipid isolubility.
b. ionization.
c. body itemperature.
d. the iconcentration iof ithe idrug.
Answer: ic
Textbook iReference: iPharmacokinetic iFactors iDetermining iDrug iAction
14. Drugs ithat iare should ibe iavoided iby iwomen iof ichildbearing iage.
a. teratogenic
b. able ito icross ithe iplacental ibarrier
c. psychoactive
d. highly ilipid-soluble
Answer: ia
Textbook iReference: iPharmacokinetic iFactors iDetermining iDrug iAction
15. Agents ithat iinduce idevelopmental iabnormalities iin ia ifetus iare iknown ias
a. psychoactive idrugs.
b. illicit idrugs.
c. teratogens.
d. placental idrugs.
Answer: ic
Textbook iReference: iPharmacokinetic iFactors iDetermining iDrug iAction
16. Depot ibinding iis isaid ito ioccur iwhen idrugs
a. bind ito itheir itarget isites.
Page 3 of 247
