Chapter 10 General Antiinflammatory Drugs
MULTIPLE CHOICE
BASIC CONCEPTS
1. Which stage of the inflammatory response involves capillary leak syndrome?
a. Stage I
b Stage II
.
c. Stage III
d Stage IV
.
ANS: A
The first stage of the inflammatory response involves white blood cells releasing chemical
substances that act on blood vessels, making the pores larger so that fluid leaks out of the blood
vessels into the damaged tissue.
DIF: Cognitive Level: Remembering REF: p. 84
2. Which corticosteroid is applied topically to the skin?
a. Betamethasone (Celestone)
b Triamcinolone (Kenalog)
.
c. Dexamethosone (Decadron)
d Methylprednisolone (Solu-Medrol)
.
ANS: B
Betemethasone and dexamethosone are oral drugs. Methylprednisolone is a parenteral drug. Of
the drugs on this list, only triamcinolone is applied as a topical drug.
DIF: Cognitive Level: Remembering REF: p. 86
3. Which problem is a common side effect of long-term corticosteroid use?
a. Acne
b Weight loss
.
c. Redness and pain
,d Low blood pressure
.
, ANS: A
Corticosteroid use has many side effects including weight gain (not loss), retention of sodium
and water leading to high blood pressure (not low blood pressure), and a lot of skin changes,
including acne. Corticosteroids are used to reduce inflammation, so they eliminate redness and
pain, they do not cause these side effects.
DIF: Cognitive Level: Remembering REF: p. 87
4. Which side effect of corticosteroid therapy is permanent even after the drug is stopped?
a. Difficulty sleeping
b Stretch marks
.
c. Weight gain
d Moon face
.
ANS: B
After corticosteroid therapy is stopped, many side effects resolve although this can take months
to years. The sleep disturbance, weight gain, and moon-shaped face do go away over time. The
stretch marks are permanent although they usually change from reddish-purple to silver over
time so that they are less noticeable.
DIF: Cognitive Level: Remembering REF: p. 87
5. Which anti-inflammatory drug is classified as a ―COX-1‖ inhibitor?
a. Hydrocortisone (Lanacort)
b. Celecoxib (Celebrex)
c. Zyleuton (Zyflo)
d Naproxen (Aleve)
.
ANS: D
Naproxen is the only COX-1 class anti-inflammatory drug on this list. Hydrocortisone is a
corticosteroid. Celecoxib is a COX-2 inhibitor, not COX-1. Zyleuton is a leukotriene inhibitor.
DIF: Cognitive Level: Remembering REF: p. 90
6. Which NSAID is a COX-2 inhibitor?
a. Celecoxib (Celebrex)
MULTIPLE CHOICE
BASIC CONCEPTS
1. Which stage of the inflammatory response involves capillary leak syndrome?
a. Stage I
b Stage II
.
c. Stage III
d Stage IV
.
ANS: A
The first stage of the inflammatory response involves white blood cells releasing chemical
substances that act on blood vessels, making the pores larger so that fluid leaks out of the blood
vessels into the damaged tissue.
DIF: Cognitive Level: Remembering REF: p. 84
2. Which corticosteroid is applied topically to the skin?
a. Betamethasone (Celestone)
b Triamcinolone (Kenalog)
.
c. Dexamethosone (Decadron)
d Methylprednisolone (Solu-Medrol)
.
ANS: B
Betemethasone and dexamethosone are oral drugs. Methylprednisolone is a parenteral drug. Of
the drugs on this list, only triamcinolone is applied as a topical drug.
DIF: Cognitive Level: Remembering REF: p. 86
3. Which problem is a common side effect of long-term corticosteroid use?
a. Acne
b Weight loss
.
c. Redness and pain
,d Low blood pressure
.
, ANS: A
Corticosteroid use has many side effects including weight gain (not loss), retention of sodium
and water leading to high blood pressure (not low blood pressure), and a lot of skin changes,
including acne. Corticosteroids are used to reduce inflammation, so they eliminate redness and
pain, they do not cause these side effects.
DIF: Cognitive Level: Remembering REF: p. 87
4. Which side effect of corticosteroid therapy is permanent even after the drug is stopped?
a. Difficulty sleeping
b Stretch marks
.
c. Weight gain
d Moon face
.
ANS: B
After corticosteroid therapy is stopped, many side effects resolve although this can take months
to years. The sleep disturbance, weight gain, and moon-shaped face do go away over time. The
stretch marks are permanent although they usually change from reddish-purple to silver over
time so that they are less noticeable.
DIF: Cognitive Level: Remembering REF: p. 87
5. Which anti-inflammatory drug is classified as a ―COX-1‖ inhibitor?
a. Hydrocortisone (Lanacort)
b. Celecoxib (Celebrex)
c. Zyleuton (Zyflo)
d Naproxen (Aleve)
.
ANS: D
Naproxen is the only COX-1 class anti-inflammatory drug on this list. Hydrocortisone is a
corticosteroid. Celecoxib is a COX-2 inhibitor, not COX-1. Zyleuton is a leukotriene inhibitor.
DIF: Cognitive Level: Remembering REF: p. 90
6. Which NSAID is a COX-2 inhibitor?
a. Celecoxib (Celebrex)
