Summary Topic 4 William Withering and Clinical Trialing

William Withering Digitalis soup


William
Withering
No preclinical
S.I units
triding
↓
Observe recovery
foxglove ,
of patient of dropsy
extract active
ingredients
after drinking to




dupply large group of patients with dropsy with
foxglove
↳ until observe toxic

lowly effects
increase
dosage side



results
Meticulously record all



Modern
day drug trialing
Potential substances are
analysed and he active
ingredient
is identified
↓
Pre-chnical trials on animals andtissue cultures are

tested
. To test
for toxic side effects
&
Clinical Phase & :
individuals
small of healthy
-



group
-


placebo group us
drug group
↳ to observe toxic side
effects
any
examining
metabolism excretion
(efficacy
-

,

-

dosage
.