Summary Topic 2 Mutation

Mutation
What is Mutation : change in DNA base sequence
mutation ?
Causes alteration protein by
:
in shape

S.I units
change in DNA base sequence
-




Change in mRNA triplet code
-




change in
Sequence
-


amino acid

-




folds differently due to
different type and
position of bonds
-different shape of protein
↳
affectsfunction .




Causes
of Carcinogens
-




mutation : -

errors in DNA replication
virul
infection
-




radiation
-




ionising

Point
Types of mutation: mutation DNA base
-
>
change in a
single

Substitution -
>
swapping of base(s)
for another
Insertion -
> addition
of a base


Deletion
of base
-
> removal a




Frameshift mutation -
>
causes
remaining
amino to be
affected/changed
changes subsequent triplet
-




every
subsequent acid
changes amino
-




every


Germ cells -
>
produce gametes
Germ line to
offspring
mutation
-
>
passed


Somatic =
body cells
Somatic not to
offspring
->
mutation passed