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BASIC AND CLINICAL PHARMACOLOGY 14thE
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Basic and Clinical Pharmacology 14th Edition Katzung Trevor Test Bank
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DITION KATZUNG TREVOR Test Bank
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Chaptere1.eIntroduction:eTheeNatureeofeDrugse&eDrugeDevelopmente&eRegulation
1.
Aenurseeworkingeineradiologyeadministerseiodineetoeaepatientewhoeisehavingea
ecomputedetomographye(CT)escan.eTheenurseeworkingeonetheeoncologyeunitead
ministersechemotherapyetoepatientsewhoehaveecancer.eAtetheePubliceHealtheDep
artment,eaenurseeadministerseaemeasles-mumps-rubellae(MMR)evaccineetoeae14-
month-
oldechildeaseaeroutineeimmunization.eWhichebrancheofepharmacologyebestedescr
ibesetheeactionseofeallethreee nurses?
A) Pharmacoeconomics
B) Pharmacotherapeutics
C) Pharmacodynamics
D) Pharmacokinetics
Ans: B
Feedback:
Pharmacologyeisetheestudyeofetheebiologiceeffectseofechemicals.eNurseseareeinvo
lvedewitheclinicalepharmacologyeorepharmacotherapeutics,ewhicheiseaebrancheof
epharmacologyethatedealsewithetheeuseseofedrugsetoetreat,eprevent,eandediagnosee
disease.eTheeradiologyenurseeiseadministeringeaedrugetoehelpediagnoseeaedisease
.eTheeoncologyenurseeiseadministeringeaedrugetoehelpetreateaedisease.ePharmacoe
conomicseincludeseanyecostseinvolvedeinedruge therapy.
Pharmacodynamicseinvolvesehoweaedrugeaffectsetheebodyeandep
harmacokineticseisehowetheebodyeactseonetheebody.
2.
Aephysicianehaseorderedeintramusculare(IM)einjectionseofemorphine,eaenarco
tic,eeverye4ehourseaseneededeforepaineineaemotorevehicleeaccidentevictim.eTheenu
rseeiseawareethisedrugehaseaehigheabuseepotential.eUnderewhatecategoryewouldem
orphineebeeclassified?
A) ScheduleeI
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B) ScheduleeII
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C) ScheduleeIII
D) ScheduleeIV
Ans: B
Feedback:
NarcoticsewitheaehigheabuseepotentialeareeclassifiedeaseScheduleeIIedrugsebecau
seeofesevereedependenceeliability.eScheduleeIedrugsehaveehigheabuseepotentiale
andenoeacceptedemedicaleuse.eScheduleeIIIedrugsehaveeaelessereabuseepotentiale
thaneIIeandeaneacceptedemedicaleuse.eScheduleeIVedrugsehaveeloweabuseepotent
ialeandelimitededependencee liability.
3.
WheneinvolvedeinephaseeIIIedrugeevaluationestudies,ewhateresponsibilitie
sewouldetheenurseehave?
A) Workingewitheanimalsewhoeareegiveneexperimentale drugs
B) Choosingeappropriateepatientsetoebeeinvolvedeinetheedruge study
C) Monitoringeandeobservingepatientsecloselyeforeadversee effects
D) Conductingeresearchetoedetermineeeffectivenesseofethee drug
Ans: C
Feedback:
PhaseeIIIestudieseinvolveeuseeofeaedrugeineaevasteclinicalepopulationeinewhichep
atientseareeaskedetoerecordeanyesymptomsetheyeexperienceewhileetakingetheedr
ugs.eNursesemayebeeresponsibleeforehelpingecollecteandeanalyzeetheeinformati
onetoebeesharedewithetheeFoodeandeDrugeAdministratione(FDA)ebutewouldenote
conducteresearcheindependentlyebecauseenursesedoenoteprescribeemedications
.eUseeofeanimalseinedrugetestingeisedoneeinetheepreclinicaletrials.eSelectepatients
ewhoeareeinvolvedeinephaseeIIestudiesetoeparticipateeinestudiesewhereetheepartic
ipantsehaveetheediseaseetheedrugeiseintendedetoetreat.eTheseepatientseareemonit
oredecloselyeforedrugeactioneandeadverseeeffects.ePhaseeIestudieseinvolveehealt
hyehumanevolunteersewhoeareeusuallyepaideforetheireparticipation.eNursesemay
eobserveeforeadverseeeffectseandetoxicity.
4.
Whateconcepteiseconsideredewhenegenericedrugseareesubstitutedeforebran
denameedrugs?
A) Bioavailability
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B) Criticaleconcentration
C) Distribution
D) Half-life
Ans: A
Feedback:
Bioavailabilityeisetheeportioneofeaedoseeofeaedrugethatereachesetheesystemicecirc
ulationeandeiseavailableetoeacteonebodyecells.eBinderseusedeineaegenericedrugema
yenotebeetheesameeasethoseeusedeinetheebrandenameedrug.eTherefore,etheewayeth
eebodyebreaksedowneandeusesetheedrugemayediffer,ewhichemayeeliminateeaegen
ericedrugesubstitution.eCriticaleconcentrationeisetheeamounteofeaedrugethateisenee
dedetoecauseeaetherapeuticeeffecteandeshouldenotedifferebetweenegenericeandebr
andenameemedications.eDistributioneisetheephaseeofepharmacokinetics,ewhichei
nvolvesetheemovementeofeaedrugetoetheebodysetissueseandeisetheesameeinegeneri
ceandebrandenameedrugs.eAedrugsehalf-
lifeeisetheetimeeitetakeseforetheeamounteofedrugetoedecreaseetoehalfetheepeakelevel,
ewhicheshouldenotechangeewhenesubstitutingeaegenerice medication.
5.
Aenurseeiseassessingetheepatientsehomeemedicationeuse.eAfterelisteningetoeth
eepatientelistecurrentemedications,etheenurseeasksewhateprioritye question?
A) Doeyouetakeeanyegenerice medications?
B) Areeanyeofetheseemedicationseorphane drugs?
C) Areetheseemedicationsesafeetoetakeeduringe pregnancy?
D) Doeyouetakeeanyeover-the-countere medications?
Ans: D
Feedback:
Iteiseimportanteforetheenurseetoespecificallyequestioneuseeofeover-the-
counteremedicationsebecauseepatientsemayenoteconsiderethemeimportant.eTheep
atienteiseunlikelyetoeknowetheemeaningeofeorphanedrugseunlessetheyetooeareehea
lthecareeproviders.eSafetyeduringepregnancy,euseeofeaegenericemedication,eorecl
assificationeofeorphanedrugseareethingsetheepatientewouldebeeunableetoeanswere
butecouldebeefoundeinereferenceebookseifetheenurseewishesetoeresearchethem.
WWW.THENURSINGMASTERY.COM
WWW.NURSYLAB.COM
BASIC AND CLINICAL PHARMACOLOGY 14thE
e
e e
e
e
e
Basic and Clinical Pharmacology 14th Edition Katzung Trevor Test Bank
e e e e
e
e e
e
DITION KATZUNG TREVOR Test Bank
e e e e
Chaptere1.eIntroduction:eTheeNatureeofeDrugse&eDrugeDevelopmente&eRegulation
1.
Aenurseeworkingeineradiologyeadministerseiodineetoeaepatientewhoeisehavingea
ecomputedetomographye(CT)escan.eTheenurseeworkingeonetheeoncologyeunitead
ministersechemotherapyetoepatientsewhoehaveecancer.eAtetheePubliceHealtheDep
artment,eaenurseeadministerseaemeasles-mumps-rubellae(MMR)evaccineetoeae14-
month-
oldechildeaseaeroutineeimmunization.eWhichebrancheofepharmacologyebestedescr
ibesetheeactionseofeallethreee nurses?
A) Pharmacoeconomics
B) Pharmacotherapeutics
C) Pharmacodynamics
D) Pharmacokinetics
Ans: B
Feedback:
Pharmacologyeisetheestudyeofetheebiologiceeffectseofechemicals.eNurseseareeinvo
lvedewitheclinicalepharmacologyeorepharmacotherapeutics,ewhicheiseaebrancheof
epharmacologyethatedealsewithetheeuseseofedrugsetoetreat,eprevent,eandediagnosee
disease.eTheeradiologyenurseeiseadministeringeaedrugetoehelpediagnoseeaedisease
.eTheeoncologyenurseeiseadministeringeaedrugetoehelpetreateaedisease.ePharmacoe
conomicseincludeseanyecostseinvolvedeinedruge therapy.
Pharmacodynamicseinvolvesehoweaedrugeaffectsetheebodyeandep
harmacokineticseisehowetheebodyeactseonetheebody.
2.
Aephysicianehaseorderedeintramusculare(IM)einjectionseofemorphine,eaenarco
tic,eeverye4ehourseaseneededeforepaineineaemotorevehicleeaccidentevictim.eTheenu
rseeiseawareethisedrugehaseaehigheabuseepotential.eUnderewhatecategoryewouldem
orphineebeeclassified?
A) ScheduleeI
WWW.THENURSINGMASTERY.COM
WWW.NURSYLAB.COM
, Pagee2eofe822
B) ScheduleeII
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WWW.NURSYLAB.COM
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C) ScheduleeIII
D) ScheduleeIV
Ans: B
Feedback:
NarcoticsewitheaehigheabuseepotentialeareeclassifiedeaseScheduleeIIedrugsebecau
seeofesevereedependenceeliability.eScheduleeIedrugsehaveehigheabuseepotentiale
andenoeacceptedemedicaleuse.eScheduleeIIIedrugsehaveeaelessereabuseepotentiale
thaneIIeandeaneacceptedemedicaleuse.eScheduleeIVedrugsehaveeloweabuseepotent
ialeandelimitededependencee liability.
3.
WheneinvolvedeinephaseeIIIedrugeevaluationestudies,ewhateresponsibilitie
sewouldetheenurseehave?
A) Workingewitheanimalsewhoeareegiveneexperimentale drugs
B) Choosingeappropriateepatientsetoebeeinvolvedeinetheedruge study
C) Monitoringeandeobservingepatientsecloselyeforeadversee effects
D) Conductingeresearchetoedetermineeeffectivenesseofethee drug
Ans: C
Feedback:
PhaseeIIIestudieseinvolveeuseeofeaedrugeineaevasteclinicalepopulationeinewhichep
atientseareeaskedetoerecordeanyesymptomsetheyeexperienceewhileetakingetheedr
ugs.eNursesemayebeeresponsibleeforehelpingecollecteandeanalyzeetheeinformati
onetoebeesharedewithetheeFoodeandeDrugeAdministratione(FDA)ebutewouldenote
conducteresearcheindependentlyebecauseenursesedoenoteprescribeemedications
.eUseeofeanimalseinedrugetestingeisedoneeinetheepreclinicaletrials.eSelectepatients
ewhoeareeinvolvedeinephaseeIIestudiesetoeparticipateeinestudiesewhereetheepartic
ipantsehaveetheediseaseetheedrugeiseintendedetoetreat.eTheseepatientseareemonit
oredecloselyeforedrugeactioneandeadverseeeffects.ePhaseeIestudieseinvolveehealt
hyehumanevolunteersewhoeareeusuallyepaideforetheireparticipation.eNursesemay
eobserveeforeadverseeeffectseandetoxicity.
4.
Whateconcepteiseconsideredewhenegenericedrugseareesubstitutedeforebran
denameedrugs?
A) Bioavailability
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, Pagee4eofe822
B) Criticaleconcentration
C) Distribution
D) Half-life
Ans: A
Feedback:
Bioavailabilityeisetheeportioneofeaedoseeofeaedrugethatereachesetheesystemicecirc
ulationeandeiseavailableetoeacteonebodyecells.eBinderseusedeineaegenericedrugema
yenotebeetheesameeasethoseeusedeinetheebrandenameedrug.eTherefore,etheewayeth
eebodyebreaksedowneandeusesetheedrugemayediffer,ewhichemayeeliminateeaegen
ericedrugesubstitution.eCriticaleconcentrationeisetheeamounteofeaedrugethateisenee
dedetoecauseeaetherapeuticeeffecteandeshouldenotedifferebetweenegenericeandebr
andenameemedications.eDistributioneisetheephaseeofepharmacokinetics,ewhichei
nvolvesetheemovementeofeaedrugetoetheebodysetissueseandeisetheesameeinegeneri
ceandebrandenameedrugs.eAedrugsehalf-
lifeeisetheetimeeitetakeseforetheeamounteofedrugetoedecreaseetoehalfetheepeakelevel,
ewhicheshouldenotechangeewhenesubstitutingeaegenerice medication.
5.
Aenurseeiseassessingetheepatientsehomeemedicationeuse.eAfterelisteningetoeth
eepatientelistecurrentemedications,etheenurseeasksewhateprioritye question?
A) Doeyouetakeeanyegenerice medications?
B) Areeanyeofetheseemedicationseorphane drugs?
C) Areetheseemedicationsesafeetoetakeeduringe pregnancy?
D) Doeyouetakeeanyeover-the-countere medications?
Ans: D
Feedback:
Iteiseimportanteforetheenurseetoespecificallyequestioneuseeofeover-the-
counteremedicationsebecauseepatientsemayenoteconsiderethemeimportant.eTheep
atienteiseunlikelyetoeknowetheemeaningeofeorphanedrugseunlessetheyetooeareehea
lthecareeproviders.eSafetyeduringepregnancy,euseeofeaegenericemedication,eorecl
assificationeofeorphanedrugseareethingsetheepatientewouldebeeunableetoeanswere
butecouldebeefoundeinereferenceebookseifetheenurseewishesetoeresearchethem.
WWW.THENURSINGMASTERY.COM
WWW.NURSYLAB.COM
