UNE Medical Biochemistry Exam 1
UPDATED Questions with CORRECT
Answers
W4
Which of the following hormones is best described as anabolic?
A) Epinephrine
B) Insulin
C) Cortisol
D) Glucagon - CORRECT ANSWER - Insulin
Insulin is an anabolic hormone while all others listed are predominantly catabolic.
T1
A 22-year old female presents to the emergency department with acute abdominal pain. She
indicates the pain came on rapidly in her mid-abdominal region. She has vomited several times
over the last 4 hours. A diagnosis of acute pancreatitis is made and she is rushed to surgery.
Elevation of which of the following serum enzymes would be consistent with this diagnosis?
A) Lactate dehydrogenase
B) Amylase
C) Troponin
D) Creatine Kinase - CORRECT ANSWER - Amylase
T1
Which of the following best describes a protein domain?
,A) Regions of a protein that have no specific function
B) A small grouping of secondary structures
C) A linker region between 2 α-helical structures
D) A section of a protein structure sufficient to form a particular chemical or physical task -
CORRECT ANSWER - A section of a protein structure sufficient to form a particular
chemical or physical task
T1, Q1
An enzyme has a mutation within the substrate binding site that reduces the binding of the
coenzyme needed for covalent catalysis.
Which of the following is likely to result as a consequence of this mutation?
A) The enzyme will function normally
B) The enzyme will use an alternative coenzyme for the reaction
C) The enzyme will no be able to form the transition state complex
D) The enzyme will not be able to bind substrate - CORRECT ANSWER - The enzyme
will not be able to form the transition state complex
*Loss of coenzyme binding will result in inability to form the transition substrate enzyme
complex*
T1
A 55-year old man is brought to the emergency room with a chief complaint of chest pain and
tingling in his left arm.
Elevation of which of the following enzymes in circulation would be most indicative of a
myocardial infarction?
,A) Amylase
B) Troponin
C) Lipase
D) Lactate Dehydrogenase - CORRECT ANSWER - Troponin
T1
Cleavage of fructose 1,6-biphosphate to dihydroxyacetone and glyceraldehyde 3-phosphate
involves the breaking of a carbon-carbon bond through a process other than oxidation or
hydrolysis.
This is achieved by what class of enzymes?
A) Lyase
B) Transferase
C) Hydrolase
D) Ligase - CORRECT ANSWER - Lyase
*Review the 6 classes of enzymes. Lyases cleave bonds between C-C, C-O, and C-N to generate
double bonds*
T1, Q1
Which of the following best describes the structure of heme?
A) An N-linked glycolysation
B) A nicotinamide structure that is readily oxidized
C) A negatively charged phosphate group
D) A planar polyphyrin ring that binds iron - CORRECT ANSWER - A planar polyphyrin
ring that binds iron
, T1
Which of the following best describes tertiary structure?
A) Interactions between single amino acids adjacent to one another
B) Interactions between α-helices and β sheets to form a domain
C) Interactions between amino acids 4 residues away from one another
D) Interactions between differing subunits of a protein - CORRECT ANSWER -
Interactions between α-helices and β sheets to form a domain
*Tertiary structure is best described as the entire three-dimensional conformation of a
polypeptide including how secondary structural features- helices, sheets, bend, turns and loops -
assemble to form domains and how these domains relate*
T1, Q1
α-helices and β sheets are primarily stabilized by which of the following interactions?
A) Van der Waals forces
B) Hydrogen bonding
C) Ionic bonding
D) Electrostatic interactions - CORRECT ANSWER - Hydrogen bonding
*All secondary structures are stabilized through hydrogen bonding. The other forces participate
in stabilizing tertiary and quaternary structures.*
T1
Hemoglobin bound to a heme is termed a holoprotein.
The heme or porphyrin ring is required for oxygen binding and it is defined as which of the
following?
UPDATED Questions with CORRECT
Answers
W4
Which of the following hormones is best described as anabolic?
A) Epinephrine
B) Insulin
C) Cortisol
D) Glucagon - CORRECT ANSWER - Insulin
Insulin is an anabolic hormone while all others listed are predominantly catabolic.
T1
A 22-year old female presents to the emergency department with acute abdominal pain. She
indicates the pain came on rapidly in her mid-abdominal region. She has vomited several times
over the last 4 hours. A diagnosis of acute pancreatitis is made and she is rushed to surgery.
Elevation of which of the following serum enzymes would be consistent with this diagnosis?
A) Lactate dehydrogenase
B) Amylase
C) Troponin
D) Creatine Kinase - CORRECT ANSWER - Amylase
T1
Which of the following best describes a protein domain?
,A) Regions of a protein that have no specific function
B) A small grouping of secondary structures
C) A linker region between 2 α-helical structures
D) A section of a protein structure sufficient to form a particular chemical or physical task -
CORRECT ANSWER - A section of a protein structure sufficient to form a particular
chemical or physical task
T1, Q1
An enzyme has a mutation within the substrate binding site that reduces the binding of the
coenzyme needed for covalent catalysis.
Which of the following is likely to result as a consequence of this mutation?
A) The enzyme will function normally
B) The enzyme will use an alternative coenzyme for the reaction
C) The enzyme will no be able to form the transition state complex
D) The enzyme will not be able to bind substrate - CORRECT ANSWER - The enzyme
will not be able to form the transition state complex
*Loss of coenzyme binding will result in inability to form the transition substrate enzyme
complex*
T1
A 55-year old man is brought to the emergency room with a chief complaint of chest pain and
tingling in his left arm.
Elevation of which of the following enzymes in circulation would be most indicative of a
myocardial infarction?
,A) Amylase
B) Troponin
C) Lipase
D) Lactate Dehydrogenase - CORRECT ANSWER - Troponin
T1
Cleavage of fructose 1,6-biphosphate to dihydroxyacetone and glyceraldehyde 3-phosphate
involves the breaking of a carbon-carbon bond through a process other than oxidation or
hydrolysis.
This is achieved by what class of enzymes?
A) Lyase
B) Transferase
C) Hydrolase
D) Ligase - CORRECT ANSWER - Lyase
*Review the 6 classes of enzymes. Lyases cleave bonds between C-C, C-O, and C-N to generate
double bonds*
T1, Q1
Which of the following best describes the structure of heme?
A) An N-linked glycolysation
B) A nicotinamide structure that is readily oxidized
C) A negatively charged phosphate group
D) A planar polyphyrin ring that binds iron - CORRECT ANSWER - A planar polyphyrin
ring that binds iron
, T1
Which of the following best describes tertiary structure?
A) Interactions between single amino acids adjacent to one another
B) Interactions between α-helices and β sheets to form a domain
C) Interactions between amino acids 4 residues away from one another
D) Interactions between differing subunits of a protein - CORRECT ANSWER -
Interactions between α-helices and β sheets to form a domain
*Tertiary structure is best described as the entire three-dimensional conformation of a
polypeptide including how secondary structural features- helices, sheets, bend, turns and loops -
assemble to form domains and how these domains relate*
T1, Q1
α-helices and β sheets are primarily stabilized by which of the following interactions?
A) Van der Waals forces
B) Hydrogen bonding
C) Ionic bonding
D) Electrostatic interactions - CORRECT ANSWER - Hydrogen bonding
*All secondary structures are stabilized through hydrogen bonding. The other forces participate
in stabilizing tertiary and quaternary structures.*
T1
Hemoglobin bound to a heme is termed a holoprotein.
The heme or porphyrin ring is required for oxygen binding and it is defined as which of the
following?
