UNE Medical Biochemistry Midterm Review
UPDATED Questions with CORRECT
Answers
Ribose and NADPH - CORRECT ANSWER - A family presents for genetic counseling.
The couple has two female children who are alive and well; however, their infant son recently
died in the nursery with severe hemolysis (lysis of red blood cells) and jaundice. The wife recalls
she lost a brother in infancy with severe hemolysis, induced after a viral infection. The physician
suspects a glucose-6-phosphate dehydrogenase deficiency, this would result in a deficiency in
which of the following compounds in red blood cells?
Transketolase - CORRECT ANSWER - A patient presents to the emergency department
with lactic acidosis. A deficiency in thiamine (TPP) is suspected and this will be consistent with
a decrease in the activity of following enzymes?
UDP-Glucose - CORRECT ANSWER - Galactose 1-phosphate is initially converted to
glucose 1-phosphate and requires which of the following compounds?
Thiamine diphosphate - CORRECT ANSWER - Which of the following cofactors is
required for transketolase activity?
Glyceraldehyde 3-phosphate - CORRECT ANSWER - Aldolase B facilities a reaction that
cleaves fructose 1-phosphate into two 3-carbon molecules that will enter glycolysis as which of
the following compounds?
Glycolysis - CORRECT ANSWER - High levels of activity of the non-oxidative portion of
the pentose phosphate pathway will directly produce intermediates of which of the following
pathways?
Glucose 6-phosphate dehydrogenase - CORRECT ANSWER - The major regulatory step
of the pentose phosphate pathway is catalyzed by which enzyme?
, VLDL particles - CORRECT ANSWER - Insulin stimulates fatty acid synthesis in the
liver. These fatty acids are transported to the adipose tissue as which of the following?
Free fatty acids - CORRECT ANSWER - A young woman goes to work without eating
breakfast and skips lunch. In this scenario, which of the following pathways is providing
substrates used to generate ATP in the liver?
Glucagon - CORRECT ANSWER - Caffeine is a natural inhibitor of phosphodiesterase. If
you were to consume a large amount of coffee you would likely see a prolonged response to
which of the following stimulants or hormones?
They enhance transcription when bound to receptors - CORRECT ANSWER - A teenage
female presenting with lack of menstruation (amenorrhea) is found to have a dysfunctional
steroid receptor characteristic of androgen insensitivity syndrome. Which of the following
statements accurately describes steroid hormones?
Intracellular receptors - CORRECT ANSWER - Steroid hormones bind which of the
following types of receptors?
They are specific to a chemical messenger - CORRECT ANSWER - Which of the
following is a characteristic of all receptors?
Free fatty acids - CORRECT ANSWER - What is the primary oxidized fuel for skeletal
muscle in the fasted state?
Cyclic-AMP response element binding protein (CREB) - CORRECT ANSWER - cAMP
elicits multiple cellular responses. The effects of cAMP on gene transcription are directly
mediated by which of the following DNA binding proteins?
GLUT4 - CORRECT ANSWER - An individual is recently diagnosed with Type 2
diabetes. In this individual, hyperglycemia may in part be due to inactivity of which of the
following glucose transporters on skeletal muscle?
UPDATED Questions with CORRECT
Answers
Ribose and NADPH - CORRECT ANSWER - A family presents for genetic counseling.
The couple has two female children who are alive and well; however, their infant son recently
died in the nursery with severe hemolysis (lysis of red blood cells) and jaundice. The wife recalls
she lost a brother in infancy with severe hemolysis, induced after a viral infection. The physician
suspects a glucose-6-phosphate dehydrogenase deficiency, this would result in a deficiency in
which of the following compounds in red blood cells?
Transketolase - CORRECT ANSWER - A patient presents to the emergency department
with lactic acidosis. A deficiency in thiamine (TPP) is suspected and this will be consistent with
a decrease in the activity of following enzymes?
UDP-Glucose - CORRECT ANSWER - Galactose 1-phosphate is initially converted to
glucose 1-phosphate and requires which of the following compounds?
Thiamine diphosphate - CORRECT ANSWER - Which of the following cofactors is
required for transketolase activity?
Glyceraldehyde 3-phosphate - CORRECT ANSWER - Aldolase B facilities a reaction that
cleaves fructose 1-phosphate into two 3-carbon molecules that will enter glycolysis as which of
the following compounds?
Glycolysis - CORRECT ANSWER - High levels of activity of the non-oxidative portion of
the pentose phosphate pathway will directly produce intermediates of which of the following
pathways?
Glucose 6-phosphate dehydrogenase - CORRECT ANSWER - The major regulatory step
of the pentose phosphate pathway is catalyzed by which enzyme?
, VLDL particles - CORRECT ANSWER - Insulin stimulates fatty acid synthesis in the
liver. These fatty acids are transported to the adipose tissue as which of the following?
Free fatty acids - CORRECT ANSWER - A young woman goes to work without eating
breakfast and skips lunch. In this scenario, which of the following pathways is providing
substrates used to generate ATP in the liver?
Glucagon - CORRECT ANSWER - Caffeine is a natural inhibitor of phosphodiesterase. If
you were to consume a large amount of coffee you would likely see a prolonged response to
which of the following stimulants or hormones?
They enhance transcription when bound to receptors - CORRECT ANSWER - A teenage
female presenting with lack of menstruation (amenorrhea) is found to have a dysfunctional
steroid receptor characteristic of androgen insensitivity syndrome. Which of the following
statements accurately describes steroid hormones?
Intracellular receptors - CORRECT ANSWER - Steroid hormones bind which of the
following types of receptors?
They are specific to a chemical messenger - CORRECT ANSWER - Which of the
following is a characteristic of all receptors?
Free fatty acids - CORRECT ANSWER - What is the primary oxidized fuel for skeletal
muscle in the fasted state?
Cyclic-AMP response element binding protein (CREB) - CORRECT ANSWER - cAMP
elicits multiple cellular responses. The effects of cAMP on gene transcription are directly
mediated by which of the following DNA binding proteins?
GLUT4 - CORRECT ANSWER - An individual is recently diagnosed with Type 2
diabetes. In this individual, hyperglycemia may in part be due to inactivity of which of the
following glucose transporters on skeletal muscle?
