,
,BURTON’S
Microbiology f b
or the b
Health Sciences b
TENTHbEDITION
Paul G. Engelkirk, PhD, MT(ASCP), SM(NRCM)
b b b b b
MicrobiologybConsultantbandbCo-
FounderbBiomedicalbEducationalbServicesb(Bio
medbEd)bRoundbRock,bTexas
Janet Duben-Engelkirk, EdD, MT(ASCP)
b b b
Biotechnology/EducationbConsultantbandbCo-
FounderbBiomedicalbEducationalbServicesb(BiomedbEd)
Roundb Rock,bTexas
, AcquisitionsbEditor:bMichaelbNobelbProdu
ctbManager:bPaulabC.bWilliamsbMarketingb
Manager:bShaunabKelley
ProductionbProjectbManager:bPriscillabCraterb Design
er:bTerrybMallon
ManufacturingbCoordinator:bMargiebOrzech
b Compositor:bS4CarlislebPublishingbService
s
TenthbEdition
©b2015bWoltersbKluwerbHealthb
2001bMarketbStreetbPhiladelp
hia,bPAb19103bUSAbLWW.com
©b2011bLippincottbWilliamsb&bWilkins,babWoltersbKluwerbbusiness,b©b2007bLippincottbWilliamsb&
b Wilkins,b©b2004bLippincottbWilliamsb&bWilkins,b©b2000bLippincottbWilliamsb&bWilkins,b©b1996b
Lippincott-Raven,b©b1992,b1988,b1983,b1979bJBbLippincottbCo.
PrintedbinbChina
Allbrightsbreserved.bThisbbookbisbprotectedbbybcopyright.bNobpartbofbthisbbookbmaybbebreproducedb
orb transmittedbinbanybformborbbybanybmeans,bincludingbasbphotocopiesborbscanned-
inborbotherbelectronicb copies,borbutilizedbbybanybinformationbstoragebandbretrievalbsystembwithoutb
writtenbpermissionbfromb thebcopyrightbowner,bexceptbforbbriefbquotationsbembodiedbinbcriticalbart
iclesbandbreviews.bMaterialsb appearingbinbthisbbookbpreparedbbybindividualsbasbpartbofbtheirboffici
albdutiesbasbU.S.bgovernmentb employeesbarebnotbcoveredbbybthebabove-
mentionedbcopyright.bTobrequestbpermission,bpleasebcontactb LippincottbWilliamsb&bWilkinsbatbTwo
bCommercebSquare,b2001bMarketbStreet,bPhiladelphia,bPAb 19103,bviabemailbatbpermissions@lww.c
om,borbviabwebsitebatblww.comb(productsbandbservices).
Libraryb ofb Congressb Cataloging-in-Publicationb Data
ISBNb 978-1-4511-8632-1
Cataloging-in-PublicationbdatabavailablebonbrequestbfrombthebPublisher.
DISCLAIMER
Carebhasbbeenbtakenbtobconfirmbthebaccuracybofbthebinformationbpresentbandbtobdescribebgenerally
b acceptedbpractices.bHowever,bthebauthors,beditors,bandbpublisherbarebnotbresponsiblebforberrorsbo
rb omissionsborbforbanybconsequencesbfrombapplicationbofbthebinformationbinbthisbbookbandbmakeb
nob warranty,bexpressedborbimplied,bwithbrespectbtobthebcurrency,bcompleteness,borbaccuracybofbthebco
ntentsb ofbthebpublication.bApplicationbofbthisbinformationbinbabparticularbsituationbremainsbthebpro
fessionalb responsibilitybofbthebpractitioner;bthebclinicalbtreatmentsbdescribedbandbrecommendedb
maybnotbbeb consideredbabsolutebandbuniversalbrecommendations.
Thebauthors,beditors,bandbpublisherbhavebexertedbeverybeffortbtobensurebthatbdrugbselectionba
ndb dosagebsetbforthbinbthisbtextbarebinbaccordancebwithbthebcurrentbrecommendationsbandbpractice
batbtheb timebofbpublication.bHowever,binbviewbofbongoingbresearch,bchangesbinbgovernmentbregulatio
ns,bandbtheb constantbflowbofbinformationbrelatingbtobdrugbtherapybandbdrugbreactions,bthebreaderbisb
urgedbtobcheckb thebpackagebinsertbforbeachbdrugbforbanybchangebinbindicationsbandbdosagebandbforba
ddedbwarningsbandb precautions.bThisbisbparticularlybimportantbwhenbthebrecommendedbagentbisba
bnewborbinfrequentlyb employedbdrug.
SomebdrugsbandbmedicalbdevicesbpresentedbinbthisbpublicationbhavebFoodbandbDrugbAdministrati
onb (FDA)bclearancebforblimitedbusebinbrestrictedbresearchbsettings.bItbisbthebresponsibilitybofbthebheal
thbcareb providerbtobascertainbthebFDAbstatusbofbeachbdrugborbdevicebplannedbforbusebinbtheirbclinic
albpractice.
Tobpurchasebadditionalbcopiesbofbthisbbook,bcallbourbcustomerbservicebdepartmentbatb(800)b638-
3030borb faxbordersbtob(301)b223-2320.bInternationalbcustomersbshouldbcallb(301)b223-2300.
VisitbLippincottbWilliamsb&bWilkinsbonbthebInternet:bhttp://www.lww.com.bLippincottbWilliamsb&b
Wilkinsbcustomerbservicebrepresentativesbarebavailablebfromb8:30bambtob6:00bpm,bEST.
9b8b7b6b5b4b3b2b1
,BURTON’S
Microbiology f b
or the b
Health Sciences b
TENTHbEDITION
Paul G. Engelkirk, PhD, MT(ASCP), SM(NRCM)
b b b b b
MicrobiologybConsultantbandbCo-
FounderbBiomedicalbEducationalbServicesb(Bio
medbEd)bRoundbRock,bTexas
Janet Duben-Engelkirk, EdD, MT(ASCP)
b b b
Biotechnology/EducationbConsultantbandbCo-
FounderbBiomedicalbEducationalbServicesb(BiomedbEd)
Roundb Rock,bTexas
, AcquisitionsbEditor:bMichaelbNobelbProdu
ctbManager:bPaulabC.bWilliamsbMarketingb
Manager:bShaunabKelley
ProductionbProjectbManager:bPriscillabCraterb Design
er:bTerrybMallon
ManufacturingbCoordinator:bMargiebOrzech
b Compositor:bS4CarlislebPublishingbService
s
TenthbEdition
©b2015bWoltersbKluwerbHealthb
2001bMarketbStreetbPhiladelp
hia,bPAb19103bUSAbLWW.com
©b2011bLippincottbWilliamsb&bWilkins,babWoltersbKluwerbbusiness,b©b2007bLippincottbWilliamsb&
b Wilkins,b©b2004bLippincottbWilliamsb&bWilkins,b©b2000bLippincottbWilliamsb&bWilkins,b©b1996b
Lippincott-Raven,b©b1992,b1988,b1983,b1979bJBbLippincottbCo.
PrintedbinbChina
Allbrightsbreserved.bThisbbookbisbprotectedbbybcopyright.bNobpartbofbthisbbookbmaybbebreproducedb
orb transmittedbinbanybformborbbybanybmeans,bincludingbasbphotocopiesborbscanned-
inborbotherbelectronicb copies,borbutilizedbbybanybinformationbstoragebandbretrievalbsystembwithoutb
writtenbpermissionbfromb thebcopyrightbowner,bexceptbforbbriefbquotationsbembodiedbinbcriticalbart
iclesbandbreviews.bMaterialsb appearingbinbthisbbookbpreparedbbybindividualsbasbpartbofbtheirboffici
albdutiesbasbU.S.bgovernmentb employeesbarebnotbcoveredbbybthebabove-
mentionedbcopyright.bTobrequestbpermission,bpleasebcontactb LippincottbWilliamsb&bWilkinsbatbTwo
bCommercebSquare,b2001bMarketbStreet,bPhiladelphia,bPAb 19103,bviabemailbatbpermissions@lww.c
om,borbviabwebsitebatblww.comb(productsbandbservices).
Libraryb ofb Congressb Cataloging-in-Publicationb Data
ISBNb 978-1-4511-8632-1
Cataloging-in-PublicationbdatabavailablebonbrequestbfrombthebPublisher.
DISCLAIMER
Carebhasbbeenbtakenbtobconfirmbthebaccuracybofbthebinformationbpresentbandbtobdescribebgenerally
b acceptedbpractices.bHowever,bthebauthors,beditors,bandbpublisherbarebnotbresponsiblebforberrorsbo
rb omissionsborbforbanybconsequencesbfrombapplicationbofbthebinformationbinbthisbbookbandbmakeb
nob warranty,bexpressedborbimplied,bwithbrespectbtobthebcurrency,bcompleteness,borbaccuracybofbthebco
ntentsb ofbthebpublication.bApplicationbofbthisbinformationbinbabparticularbsituationbremainsbthebpro
fessionalb responsibilitybofbthebpractitioner;bthebclinicalbtreatmentsbdescribedbandbrecommendedb
maybnotbbeb consideredbabsolutebandbuniversalbrecommendations.
Thebauthors,beditors,bandbpublisherbhavebexertedbeverybeffortbtobensurebthatbdrugbselectionba
ndb dosagebsetbforthbinbthisbtextbarebinbaccordancebwithbthebcurrentbrecommendationsbandbpractice
batbtheb timebofbpublication.bHowever,binbviewbofbongoingbresearch,bchangesbinbgovernmentbregulatio
ns,bandbtheb constantbflowbofbinformationbrelatingbtobdrugbtherapybandbdrugbreactions,bthebreaderbisb
urgedbtobcheckb thebpackagebinsertbforbeachbdrugbforbanybchangebinbindicationsbandbdosagebandbforba
ddedbwarningsbandb precautions.bThisbisbparticularlybimportantbwhenbthebrecommendedbagentbisba
bnewborbinfrequentlyb employedbdrug.
SomebdrugsbandbmedicalbdevicesbpresentedbinbthisbpublicationbhavebFoodbandbDrugbAdministrati
onb (FDA)bclearancebforblimitedbusebinbrestrictedbresearchbsettings.bItbisbthebresponsibilitybofbthebheal
thbcareb providerbtobascertainbthebFDAbstatusbofbeachbdrugborbdevicebplannedbforbusebinbtheirbclinic
albpractice.
Tobpurchasebadditionalbcopiesbofbthisbbook,bcallbourbcustomerbservicebdepartmentbatb(800)b638-
3030borb faxbordersbtob(301)b223-2320.bInternationalbcustomersbshouldbcallb(301)b223-2300.
VisitbLippincottbWilliamsb&bWilkinsbonbthebInternet:bhttp://www.lww.com.bLippincottbWilliamsb&b
Wilkinsbcustomerbservicebrepresentativesbarebavailablebfromb8:30bambtob6:00bpm,bEST.
9b8b7b6b5b4b3b2b1
