GMS 6121 Exam 1 Module 4.1 to 4.2
(EU)questions with complete solutions
T/F: Majority of viral infections are subclinical (asymptomatic) - correct answer ✔✔True
What are the two components of viral disease in viral pathogenesis?
Effects of the virus _____ on the host
Effects of host _____ on the virus and the host - correct answer ✔✔Effects of the virus replication on the
host
Effects of host response on the virus and the host
What is the term?
The process by which one organism causes disease in another - correct answer ✔✔Pathogenesis
why study pathogenesis? - correct answer ✔✔understand interaction of viruses with host cells, one can
identify antiviral drug targets
can understand how immune system targets
identify virulence factors or antigenic epitopes, design effective vaccines
What is tamiflu? - correct answer ✔✔targets influenza neuraminidase, inhibits
permissive cell = supports influenza infection
, after budding to leave host cell, virion remains stuck, encodes neuraminidase to cleave sialic acid and
release
tamiflu binds neuraminidase so virions cannot spread
Why study viral pathogenesis?
1)By understanding the interaction of viruses with host cells, one can identify targets for _____drugs
2)By understanding how viruses interact with the immune system, one can identify target for _____
3)By identifying viral ____factors (i.e. live attenuated vaccines) or antigenic ____(i.e. subunit vaccines),
one can design efficacious vaccines - correct answer ✔✔1)By understanding the interaction of viruses
with host cells, one can identify targets for antiviral drugs
2)By understanding how viruses interact with the immune system, one can identify target for
immunomodulation
3)By identifying viral virulence factors (i.e. live attenuated vaccines) or antigenic epitopes (i.e. subunit
vaccines), one can design efficacious vaccines
What are points of viral entry? - correct answer ✔✔anywhere they can come into contact with host from
external environment
skin
eyes (conjunctiva)
along any exposed mucosal surfaces = GI, urogenital, resp
Describe the skin as a barrier - correct answer ✔✔Barriers to infection: the outer layer of dead
keratinized cells cannot support viral infection
Virus entry: in order to infect, must break/puncture to reach live layers epithelium= needle punctures,
abrasions, insect/animal bites
severity depends on how deep virus is deposited
(EU)questions with complete solutions
T/F: Majority of viral infections are subclinical (asymptomatic) - correct answer ✔✔True
What are the two components of viral disease in viral pathogenesis?
Effects of the virus _____ on the host
Effects of host _____ on the virus and the host - correct answer ✔✔Effects of the virus replication on the
host
Effects of host response on the virus and the host
What is the term?
The process by which one organism causes disease in another - correct answer ✔✔Pathogenesis
why study pathogenesis? - correct answer ✔✔understand interaction of viruses with host cells, one can
identify antiviral drug targets
can understand how immune system targets
identify virulence factors or antigenic epitopes, design effective vaccines
What is tamiflu? - correct answer ✔✔targets influenza neuraminidase, inhibits
permissive cell = supports influenza infection
, after budding to leave host cell, virion remains stuck, encodes neuraminidase to cleave sialic acid and
release
tamiflu binds neuraminidase so virions cannot spread
Why study viral pathogenesis?
1)By understanding the interaction of viruses with host cells, one can identify targets for _____drugs
2)By understanding how viruses interact with the immune system, one can identify target for _____
3)By identifying viral ____factors (i.e. live attenuated vaccines) or antigenic ____(i.e. subunit vaccines),
one can design efficacious vaccines - correct answer ✔✔1)By understanding the interaction of viruses
with host cells, one can identify targets for antiviral drugs
2)By understanding how viruses interact with the immune system, one can identify target for
immunomodulation
3)By identifying viral virulence factors (i.e. live attenuated vaccines) or antigenic epitopes (i.e. subunit
vaccines), one can design efficacious vaccines
What are points of viral entry? - correct answer ✔✔anywhere they can come into contact with host from
external environment
skin
eyes (conjunctiva)
along any exposed mucosal surfaces = GI, urogenital, resp
Describe the skin as a barrier - correct answer ✔✔Barriers to infection: the outer layer of dead
keratinized cells cannot support viral infection
Virus entry: in order to infect, must break/puncture to reach live layers epithelium= needle punctures,
abrasions, insect/animal bites
severity depends on how deep virus is deposited
