Pharmacology Exam 1
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1. pharmacokinetics relationship between drug dosage and concentra-
tion in plasma over time, determines onset, duration,
and intensity of drug
2. pharmacodynamics relationship between drug concentration over time
and therapeutic response
3. chemical specificity specificity between receptors and bonds, EX strict
for receptors structural requirements for binding
4. receptor saturability only a finite number of receptors that can be occu-
pied
5. receptor affinity measure of attraction between drug and receptor
6. drug potency dose required to have certain effect, related to affin-
ity of receptor
7. ED50 dose which produces 50% of maximum effect, used
to compare drugs in terms of potency
8. drug efficacy maximal effect achievable for a drug, related to num-
ber of receptor/complexes formed, intrinsic activity
of drug in activating receptor
9. full agonist affinity to, and full activator, of receptor (high intrin-
sic activity/efficacy), increases activity above basal
level of receptor where receptor has a constitutive
(intrinsic basal) level of activity in the absence of a
ligand
10. inverse agonist affinity to, and full activator of receptor (high intrinsic
activity/efficacy), but has exact opposite effect of full
agonist (metoprolol), decreases activity below basal
level of receptor where receptor has a constitutive
(intrinsic basal) level of activity in the absence of a
ligand
11. partial agonist
, Pharmacology Exam 1
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affinity to receptor but only partially activates a re-
ceptor, produces less than the ceiling effect of a full
agonist
12. pure antagonist affinity to receptor but produces no activation, dose
curve is a straight line across the bottom of an
XY graph (EX oraverse vasodilates, overcoming the
vasocontriction of the LA)
13. neutral antgonist has no activity in the absence of an agonist or in-
verse agonist but can block either's activity
14. competitive antago- lacks efficacy, competes with agonists for binding
nist sites, inhibitory effect can be overcome by increas-
ing concentration of competing agonist
15. every drug produces a
variety of effects, we
hope we can get sep-
aration from things we
want and adverse side
effects, this is differ-
ent for every patient
16. know the second slide which drugs is most potent, least potenet, most
on page 10 of princi- efficient and least efficient
ples of drugs
17. physiological antago- stimulates competing/opposite physiological re-
nism sponses which counteract the effects of a therapeu-
tic drug, the inhibitory effect can *NOT* be over-
come by increasing the agonist dosage (EX epi is
used during anaphylaxis to produce physiological
responses instead of an antihistamine which is only
a competing antagonist)
18. exam will ask you
to explain interactions
between drugs in ref-
erence to physiolog-
Study online at https://quizlet.com/_1ho5fp
1. pharmacokinetics relationship between drug dosage and concentra-
tion in plasma over time, determines onset, duration,
and intensity of drug
2. pharmacodynamics relationship between drug concentration over time
and therapeutic response
3. chemical specificity specificity between receptors and bonds, EX strict
for receptors structural requirements for binding
4. receptor saturability only a finite number of receptors that can be occu-
pied
5. receptor affinity measure of attraction between drug and receptor
6. drug potency dose required to have certain effect, related to affin-
ity of receptor
7. ED50 dose which produces 50% of maximum effect, used
to compare drugs in terms of potency
8. drug efficacy maximal effect achievable for a drug, related to num-
ber of receptor/complexes formed, intrinsic activity
of drug in activating receptor
9. full agonist affinity to, and full activator, of receptor (high intrin-
sic activity/efficacy), increases activity above basal
level of receptor where receptor has a constitutive
(intrinsic basal) level of activity in the absence of a
ligand
10. inverse agonist affinity to, and full activator of receptor (high intrinsic
activity/efficacy), but has exact opposite effect of full
agonist (metoprolol), decreases activity below basal
level of receptor where receptor has a constitutive
(intrinsic basal) level of activity in the absence of a
ligand
11. partial agonist
, Pharmacology Exam 1
Study online at https://quizlet.com/_1ho5fp
affinity to receptor but only partially activates a re-
ceptor, produces less than the ceiling effect of a full
agonist
12. pure antagonist affinity to receptor but produces no activation, dose
curve is a straight line across the bottom of an
XY graph (EX oraverse vasodilates, overcoming the
vasocontriction of the LA)
13. neutral antgonist has no activity in the absence of an agonist or in-
verse agonist but can block either's activity
14. competitive antago- lacks efficacy, competes with agonists for binding
nist sites, inhibitory effect can be overcome by increas-
ing concentration of competing agonist
15. every drug produces a
variety of effects, we
hope we can get sep-
aration from things we
want and adverse side
effects, this is differ-
ent for every patient
16. know the second slide which drugs is most potent, least potenet, most
on page 10 of princi- efficient and least efficient
ples of drugs
17. physiological antago- stimulates competing/opposite physiological re-
nism sponses which counteract the effects of a therapeu-
tic drug, the inhibitory effect can *NOT* be over-
come by increasing the agonist dosage (EX epi is
used during anaphylaxis to produce physiological
responses instead of an antihistamine which is only
a competing antagonist)
18. exam will ask you
to explain interactions
between drugs in ref-
erence to physiolog-
