PRE TEST PCOL 1 Exam with 100%
Correct Answers
pharmacology - correct answer-the study of substances that interact with living systems
through chemical processes
medical pharmacology - correct answer-defined as the science of substances used to
prevent, diagnose, and treat disease
toxicology - correct answer-branch of pharmacology that deals with the undesirable
effects of chemicals on living systems, from individual cells to humans to complex
ecosystems
medical pharmacology and toxicology
environmental toxicology - correct answer-major areas of study in pcol
materia medica - science of drug preparation and the medical uses of drugs - correct
answer-began to develop as the precursor to pharmacology.
François Magendie
Claude Bernard - correct answer-develop the methods of experimental physiology and
pharmacology.
drug receptor - correct answer-biologic substrate of that action
orphan receptors - correct answer-receptors for which no ligand has been discovered
and whose function can only be guessed.
Pharmacogenomics - correct answer-the relation of the individual's genetic makeup to
his or her response to specific drug
chemicals in botanicals (herbs and plant extracts) - correct answer-what are
nutraceuticals
FALSE, - correct answer-chemicals in botanicals are different from chemicals in
manufactured drugs
Paracelsus - correct answer-"the dose makes the poison,"
toxins - correct answer-poisons of biologic origin
, between 100 and 1000. - correct answer-T/F: most drugs have molecular weights
between 1000 and 10000
covalent, electrostatic, and hydrophobic - correct answer-Drugs interact with receptors
by means of chemical forces or bonds. What are those?
xe - correct answer-an "inert" gas, has anesthetic effects at elevated pressures.
Rational design of drugs - correct answer-implies the ability to predict the appro- priate
molecular structure of a drug on the basis of information about its biologic receptor.
agonist - correct answer-bind to and activate the receptor in some fashion, which
directly or indirectly brings about the effect
Pharmacologic antagonist drugs - correct answer-by binding to a receptor, compete with
and prevent binding by other molecules.
partial agonists - correct answer-bind to the same receptors and acti- vate them in the
same way but do not evoke as great a response, no matter how high the concentration.
constitutive activity. - correct answer-Thermodynamic considerations indicate that even
in the absence of any agonist, some of the receptor pool must exist in the Ra form some
of the time and may produce the same physiologic effect as agonist-induced activity.
γ-aminobutyric acid (GABA A) - correct answer-example of inverse agonists (> aff to Ri)
prodrug - correct answer-readily absorbed and distributed must be adminis- tered and
then converted to the active drug by biologic processes
Lipid diffusion - correct answer-The most important limiting factor for drug permeation
P-glycoprotein or multidrug resistance type 1 (MDR1) transporter - correct answer-found
in the brain, testes, and other tis- sues, and in some drug-resistant neoplastic cells
multidrug resistance-associated protein (MRP) transporters, - correct answer-play
impor- tant roles in the excretion of some drugs or their metabolites into urine and bile
and in the resistance of some tumors to chemotherapeutic drugs.
endocytosis - correct answer-process by which the substance is bound at a cell-surface
recep- tor, engulfed by the cell membrane, and carried into the cell by pinching off of the
newly formed vesicle inside the membrane.
endocytosis - correct answer-This process is responsible for the transport of vitamin
B12
Correct Answers
pharmacology - correct answer-the study of substances that interact with living systems
through chemical processes
medical pharmacology - correct answer-defined as the science of substances used to
prevent, diagnose, and treat disease
toxicology - correct answer-branch of pharmacology that deals with the undesirable
effects of chemicals on living systems, from individual cells to humans to complex
ecosystems
medical pharmacology and toxicology
environmental toxicology - correct answer-major areas of study in pcol
materia medica - science of drug preparation and the medical uses of drugs - correct
answer-began to develop as the precursor to pharmacology.
François Magendie
Claude Bernard - correct answer-develop the methods of experimental physiology and
pharmacology.
drug receptor - correct answer-biologic substrate of that action
orphan receptors - correct answer-receptors for which no ligand has been discovered
and whose function can only be guessed.
Pharmacogenomics - correct answer-the relation of the individual's genetic makeup to
his or her response to specific drug
chemicals in botanicals (herbs and plant extracts) - correct answer-what are
nutraceuticals
FALSE, - correct answer-chemicals in botanicals are different from chemicals in
manufactured drugs
Paracelsus - correct answer-"the dose makes the poison,"
toxins - correct answer-poisons of biologic origin
, between 100 and 1000. - correct answer-T/F: most drugs have molecular weights
between 1000 and 10000
covalent, electrostatic, and hydrophobic - correct answer-Drugs interact with receptors
by means of chemical forces or bonds. What are those?
xe - correct answer-an "inert" gas, has anesthetic effects at elevated pressures.
Rational design of drugs - correct answer-implies the ability to predict the appro- priate
molecular structure of a drug on the basis of information about its biologic receptor.
agonist - correct answer-bind to and activate the receptor in some fashion, which
directly or indirectly brings about the effect
Pharmacologic antagonist drugs - correct answer-by binding to a receptor, compete with
and prevent binding by other molecules.
partial agonists - correct answer-bind to the same receptors and acti- vate them in the
same way but do not evoke as great a response, no matter how high the concentration.
constitutive activity. - correct answer-Thermodynamic considerations indicate that even
in the absence of any agonist, some of the receptor pool must exist in the Ra form some
of the time and may produce the same physiologic effect as agonist-induced activity.
γ-aminobutyric acid (GABA A) - correct answer-example of inverse agonists (> aff to Ri)
prodrug - correct answer-readily absorbed and distributed must be adminis- tered and
then converted to the active drug by biologic processes
Lipid diffusion - correct answer-The most important limiting factor for drug permeation
P-glycoprotein or multidrug resistance type 1 (MDR1) transporter - correct answer-found
in the brain, testes, and other tis- sues, and in some drug-resistant neoplastic cells
multidrug resistance-associated protein (MRP) transporters, - correct answer-play
impor- tant roles in the excretion of some drugs or their metabolites into urine and bile
and in the resistance of some tumors to chemotherapeutic drugs.
endocytosis - correct answer-process by which the substance is bound at a cell-surface
recep- tor, engulfed by the cell membrane, and carried into the cell by pinching off of the
newly formed vesicle inside the membrane.
endocytosis - correct answer-This process is responsible for the transport of vitamin
B12
