BLOOD
Blood is a Connective Tissue → Basophils
Plasma → Eosinophils
Liquid portion of Blood → Neutrophils
Matrix of this Connective Tissue Lymphoblasts → Lymphocytes
Not same as Serum Monoblasts → Monocytes
Blood Spun in Centrifuge forms 3 Layers Basophils, Eosinophils, Neutrophils, Lymphocytes, and
Plasma Monocytes are the White Blood Cells
Buffy Layer (= Buffy Coat) Megakaryoblasts → Megakaryocytes
Megakaryocytes = the human thrombocyte
(White Blood Cells and Platelets)
Fragment to form Platelets
Packed Red Blood Cells
Erythrocytes (Red Blood Cells)
Plasma Proteins (most produced in Liver)
Hemoglobin (Hb or Hgb)
Albumin
4 Polypeptide Chains (4 subunits)
Responsible for most of Osmotic
Pressure of blood 2 Alpha Chains ( Chains)
Carrier molecule 2 Beta Chains ( Chains)
Globulins Each Chain has a Heme Group
Heme Groups have Fe at center
Alpha-1 (1) Globulin
Each Heme Group can bind one
Carrier molecule
molecule of Oxygen (O2)
Alpha-2 (2) Globulin Oxyhemoglobin
Carrier molecule
Deoxyhemoglobin
Beta () Globulin
Carrier molecule
Carbaminohemoglobin
Gamma (γ) Globulin Carboxyhemoglobin
Produced by certain Lymphocytes Sickle Cell Trait
≈ Antibodies Anemia (= hemoglobin deficiency)
Fibrinogen Sickle Cell Anemia
Formed Elements Iron Deficiency Anemia
Erythrocytes (Red Blood Cells, = RBC’s) Pernicious Anemia
Leukocytes (White Blood Cells) Vitamin B12
Thrombocytes Intrinsic Factor
(Thrombocyte fragments = Platelets) Clinical Assessment
Hematopoiesis (= Hemopoiesis) Red Blood Cell Count
Mostly occurs in Red Bone Marrow Hemocytometer
(Red Marrow vs. Yellow/White Marrow) Hematocrit (= Packed
However, most Lymphocytes produced in Cell Volume, = PCV)
Lymphatic Tissues Volume Packed RBC’s x 100
Total Volume of Sample
Tallquist Paper Blot
Lineage of Blood Cells
Spectrophotometry
Hemocytoblasts (stem cells)
Spectrophotometer
Proerythroblasts → Erythrocytes
= Colorimeter
(continued)
Myeloblasts
Blood is a Connective Tissue → Basophils
Plasma → Eosinophils
Liquid portion of Blood → Neutrophils
Matrix of this Connective Tissue Lymphoblasts → Lymphocytes
Not same as Serum Monoblasts → Monocytes
Blood Spun in Centrifuge forms 3 Layers Basophils, Eosinophils, Neutrophils, Lymphocytes, and
Plasma Monocytes are the White Blood Cells
Buffy Layer (= Buffy Coat) Megakaryoblasts → Megakaryocytes
Megakaryocytes = the human thrombocyte
(White Blood Cells and Platelets)
Fragment to form Platelets
Packed Red Blood Cells
Erythrocytes (Red Blood Cells)
Plasma Proteins (most produced in Liver)
Hemoglobin (Hb or Hgb)
Albumin
4 Polypeptide Chains (4 subunits)
Responsible for most of Osmotic
Pressure of blood 2 Alpha Chains ( Chains)
Carrier molecule 2 Beta Chains ( Chains)
Globulins Each Chain has a Heme Group
Heme Groups have Fe at center
Alpha-1 (1) Globulin
Each Heme Group can bind one
Carrier molecule
molecule of Oxygen (O2)
Alpha-2 (2) Globulin Oxyhemoglobin
Carrier molecule
Deoxyhemoglobin
Beta () Globulin
Carrier molecule
Carbaminohemoglobin
Gamma (γ) Globulin Carboxyhemoglobin
Produced by certain Lymphocytes Sickle Cell Trait
≈ Antibodies Anemia (= hemoglobin deficiency)
Fibrinogen Sickle Cell Anemia
Formed Elements Iron Deficiency Anemia
Erythrocytes (Red Blood Cells, = RBC’s) Pernicious Anemia
Leukocytes (White Blood Cells) Vitamin B12
Thrombocytes Intrinsic Factor
(Thrombocyte fragments = Platelets) Clinical Assessment
Hematopoiesis (= Hemopoiesis) Red Blood Cell Count
Mostly occurs in Red Bone Marrow Hemocytometer
(Red Marrow vs. Yellow/White Marrow) Hematocrit (= Packed
However, most Lymphocytes produced in Cell Volume, = PCV)
Lymphatic Tissues Volume Packed RBC’s x 100
Total Volume of Sample
Tallquist Paper Blot
Lineage of Blood Cells
Spectrophotometry
Hemocytoblasts (stem cells)
Spectrophotometer
Proerythroblasts → Erythrocytes
= Colorimeter
(continued)
Myeloblasts
