©BRAINBARTER EXAM SOLUTIONS 2024/2025
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PHRM30002 Drugs Exam Study Guide.
Reserpine - answer✔Irreversibly inhibits VMAT and depletes NA stores
Tyramine/amphetamine - answer✔Displaces NA from vesicles, with low affinity for MAO
Guanethedine - answer✔Blocks calcium channels and stops vesicular exocytosis of NA and all
other stored neurotransmitters
Cocaine - answer✔Blocks reuptake of monoamines
Barbiturates - answer✔Positive allosteric modulators of GABAa receptor that increase firing
time
PCP - answer✔Negative allosteric modulator of NMDA receptors that decreases calcium influx
Ketamine - answer✔NMDA receptor antagonist
Memantine - answer✔Inhibits currents produced by NMDA receptors with low affinity to spare
normal Glu signalling (Parkinson's)
Riluzole - answer✔Blocks calcium channels to decrease Glu release and modestly extend life of
ALS patients. Also inhibits reuptake of Glu
1|Page
ALL RIGHTS RESERVED.
PHRM30002 Drugs Exam Study Guide.
Reserpine - answer✔Irreversibly inhibits VMAT and depletes NA stores
Tyramine/amphetamine - answer✔Displaces NA from vesicles, with low affinity for MAO
Guanethedine - answer✔Blocks calcium channels and stops vesicular exocytosis of NA and all
other stored neurotransmitters
Cocaine - answer✔Blocks reuptake of monoamines
Barbiturates - answer✔Positive allosteric modulators of GABAa receptor that increase firing
time
PCP - answer✔Negative allosteric modulator of NMDA receptors that decreases calcium influx
Ketamine - answer✔NMDA receptor antagonist
Memantine - answer✔Inhibits currents produced by NMDA receptors with low affinity to spare
normal Glu signalling (Parkinson's)
Riluzole - answer✔Blocks calcium channels to decrease Glu release and modestly extend life of
ALS patients. Also inhibits reuptake of Glu
1|Page
