ABGC Boards Prenatal Study Set Questions and Answers 100% Pass

ABGC Boards Prenatal Study Set Questions and Answers 100% Pass T21 Risk by Maternal Age - Age-------------------------------Risk 30 --------------------------------1/952 (.1%) 35 --------------------------------1/385 (.3%) 37 --------------------------------1/227 (.4%) 40 --------------------------------1/106 (.9%) 43 --------------------------------1/50 (3.1%) Risk of Any Chrom Abnl by Maternal Age - Age--------------------------------Risk 30---------------------------------1/384 (0.3%) 35---------------------------------1/202 (0.5%) 37---------------------------------1/129 (0.8%) 40---------------------------------1/65 (1.6%) 43---------------------------------1/32 (3.1%) Maternal Serum Quad Screen - Measurement of biochemical analytes in maternal serum to provide adjusted risk for certain conditions. Performed during second trimester typically 14-21 weeks SLO vs XL ichthyosis, Page 2/29 Crafted for Academic Insight by KatelynWhitman. All rights reserved © 2025 SLO has pre and postnatal growth restrictions - Differentials for extremely low uE3 on QUAD screen and how can you differentiate Non-disjunction in Meiosis I - What is the most common cause of aneuploidy Quad screen conditions - -Open Neural tube defects - Down Syndrome - Trisomy 18 Quad screen analytes - -AFP (alpha-fetoprotein) -hCG (human chorionic gonadotrophin): -uE3 (unconjugated estriol): - Inhibin Factors to take into account for Quad Screen - Gestational Age: As this changes so does expected values of each analyte Weight: as maternal weight increases so does blood volume. Dilutes analytes Race: Different ethnic backgrounds can affected expected levels Page 3/29 Crafted for Academic Insight by KatelynWhitman. All rights reserved © 2025 - i.e. African American ancestry tend to have higher AFP levels -Diabetic status: insulin dependent diabetics tend to have lower AFP Effects of inaccurate dating for Quad Screen - -Overestimate (believe pregnancy is further along) can lead to false positive for Down syndrome. (Overestimate brings you down) - Underestimate (reported to be earlier than it is) leads to false positive for NTD. London (The under is the tubes) - Generally use first trimester ultrasound for dating rather than LMP IgM (Most recent) IgG (It is gone) - You see IgM but not IgG is this more concerning for recent infections due to maternal infection. Memory device Estriol and hCG low but AFP high early All low: Late - Patterns for recent and older fetal demise Trends of Analytes in Second Trimester - Analyte Trend Page 4/29 Crafted for Academic Insight by KatelynWhitman. All rights reserved © 2025 hCG Decreases as GA increases Inhibin Remains Stable uE3 Increases with GA AFP increases with GA Positive Quad screen pattern Increased risk for Down Syndrome - HI (Increased) LO (Decreased) H: hCG I: Inhibin L: estriol O: AFP Quad screen positive T18 increased risk - AFP: Low hCG: Low uE3: Low DIA: N/A Pattern of Quad screen with abnormal placental functioning - AFP: HI