CMN 548 Unit 5 EXAM WITH 128 QUESTIONS &
CORRECT ANSWERS GRADED A
Potency - ANSWER-refers to the relative dose required to achieve certain effects,
not to the efficacy of a drug
Agonist (full agonist) - ANSWER-A drug that binds to a specific receptor
producing an effect identical to that usually produced by the neurotransmitter
affecting that receptor
Pharmacodynamics - ANSWER-The time course and intensity of a drug's
effect/what the drug does to the body
Pharmacokinetics - ANSWER-What the body does to a drug
Tolerance - ANSWER-Develops over time a need to use increased doses of a
medication/drug to maintain a clinical effect. Or, a decreased sensitivity to adverse
effects of a drug
Stevens-Johnson Syndrome - ANSWER-A systemic, immune-mediated reaction
that can be fatal or result in permanent scarring or blindness
Antagonist - ANSWER-A compound that blinds to a receptor that blocks or
reduces the action of another substance at the receptor site
Hyponatremia - ANSWER-Common symptoms of this medication side effect
include confusion, agitation, and lethargy. (tx with oxcarbazepine & SSRIs)
,Therapeutic index - ANSWER-ratio of the median toxic dose to the median
effective dose
Somnolence - ANSWER-Daytime sleepiness
Black Box Warning - ANSWER-This warning reflects that a medication may
cause a serious or even life-threatening side effect
Partial or Mixed Agonist - ANSWER-A compound that elicits a partial
pharmacological response at the receptor site involved
Remission - ANSWER-The degree of improvement to below the syndromal
threshold of a disorder
Paradoxical - ANSWER-A response to a drug that represents the clinical effect
opposite of what is expected
Inverse agonist - ANSWER-An agent that binds to the same receptor site as an
agonist but produces the opposite pharmacological effect
4 major transmitters - ANSWER-Dopamine, Serotonin, GABA, Norepinephrine
Dopamine transmitter affects? - ANSWER-affects mood, Psychosis, ADHD,
Addiction
Serotonin transmitter affects? - ANSWER-Depression, aggression, OCD, Panic,
GAD, Social Anxiety, PTSD, Violence, Sexual dysfunction, substance addiction
, Norepinephrine affects? - ANSWER-Affects mood, anxiety, psychosis, ADHD
(part), drug withdrawal
GABA affects? - ANSWER-Fear, anxiety, worry
Irreversible MAOIs Types - ANSWER-MAOa and MAOb
Irreversible MAOIs medications - ANSWER-Phenelzine (Nardil)
isocarboxazid (Marplan)
tranylcypromine (Parnate)
A single dose of MAOIs may persist in its inhibition of MAO for how long? -
ANSWER-because they irreversibly inactivate MAOs, the therapeutic effect of a
single dose of irreversible MAOIs may persist for as long as 2 weeks
What are the most frequent adverse effects of MAOIs? - ANSWER-orthostatic
hypotension, insomnia, weight gain, edema, sexual dysfunction
Reversible MAOIs (RIMAs) medications? - ANSWER-Moclobemide (Maerix)
How long will it take to recover MAO activity after a final dose of RIMA? -
ANSWER-MAO activity recovers completely 24-48 hrs after the last dose of a
RIMA
MAOIs are used to treat what conditions? - ANSWER-depression
panic disorder
CORRECT ANSWERS GRADED A
Potency - ANSWER-refers to the relative dose required to achieve certain effects,
not to the efficacy of a drug
Agonist (full agonist) - ANSWER-A drug that binds to a specific receptor
producing an effect identical to that usually produced by the neurotransmitter
affecting that receptor
Pharmacodynamics - ANSWER-The time course and intensity of a drug's
effect/what the drug does to the body
Pharmacokinetics - ANSWER-What the body does to a drug
Tolerance - ANSWER-Develops over time a need to use increased doses of a
medication/drug to maintain a clinical effect. Or, a decreased sensitivity to adverse
effects of a drug
Stevens-Johnson Syndrome - ANSWER-A systemic, immune-mediated reaction
that can be fatal or result in permanent scarring or blindness
Antagonist - ANSWER-A compound that blinds to a receptor that blocks or
reduces the action of another substance at the receptor site
Hyponatremia - ANSWER-Common symptoms of this medication side effect
include confusion, agitation, and lethargy. (tx with oxcarbazepine & SSRIs)
,Therapeutic index - ANSWER-ratio of the median toxic dose to the median
effective dose
Somnolence - ANSWER-Daytime sleepiness
Black Box Warning - ANSWER-This warning reflects that a medication may
cause a serious or even life-threatening side effect
Partial or Mixed Agonist - ANSWER-A compound that elicits a partial
pharmacological response at the receptor site involved
Remission - ANSWER-The degree of improvement to below the syndromal
threshold of a disorder
Paradoxical - ANSWER-A response to a drug that represents the clinical effect
opposite of what is expected
Inverse agonist - ANSWER-An agent that binds to the same receptor site as an
agonist but produces the opposite pharmacological effect
4 major transmitters - ANSWER-Dopamine, Serotonin, GABA, Norepinephrine
Dopamine transmitter affects? - ANSWER-affects mood, Psychosis, ADHD,
Addiction
Serotonin transmitter affects? - ANSWER-Depression, aggression, OCD, Panic,
GAD, Social Anxiety, PTSD, Violence, Sexual dysfunction, substance addiction
, Norepinephrine affects? - ANSWER-Affects mood, anxiety, psychosis, ADHD
(part), drug withdrawal
GABA affects? - ANSWER-Fear, anxiety, worry
Irreversible MAOIs Types - ANSWER-MAOa and MAOb
Irreversible MAOIs medications - ANSWER-Phenelzine (Nardil)
isocarboxazid (Marplan)
tranylcypromine (Parnate)
A single dose of MAOIs may persist in its inhibition of MAO for how long? -
ANSWER-because they irreversibly inactivate MAOs, the therapeutic effect of a
single dose of irreversible MAOIs may persist for as long as 2 weeks
What are the most frequent adverse effects of MAOIs? - ANSWER-orthostatic
hypotension, insomnia, weight gain, edema, sexual dysfunction
Reversible MAOIs (RIMAs) medications? - ANSWER-Moclobemide (Maerix)
How long will it take to recover MAO activity after a final dose of RIMA? -
ANSWER-MAO activity recovers completely 24-48 hrs after the last dose of a
RIMA
MAOIs are used to treat what conditions? - ANSWER-depression
panic disorder
