©THEBRIGHT EXAM SOLUTIONS
11/7/2024 12:35 PM
PHAR 100 Final Exam from Jud Study
Guide.
Codeine - answer✔0.5% opium
Pain relief
Morphine - answer✔10% opium
Immense pain reliever
Gold standard drug
Curare - answer✔Indigenous people dipped arrows, causing paralysis to animals
Paul Enrlich (father of chemo)
Gerhard Domagk
Alexander Fleming
Selman Waksman
Morton - answer✔Organoarsenicals--> syphilis
Sulfa drugs
Penicillin
Streptomyocin (TB)
Ether
Receptor - answer✔Molecule located on the inside or outside of a cell that has a regulatory role
in homeostasis
Agonists - answer✔Drugs that bind to a receptor and stimulate it
Antagonists - answer✔Drugs that bind to a receptor but block the response that it normally
elicits
, ©THEBRIGHT EXAM SOLUTIONS
11/7/2024 12:35 PM
Dose-Response Relationship - answer✔Intensity is proportional to dosage
Low dose = little response; not enough receptors activated
Threshold dose = enough receptors activated to elicit response
Past threshold = small increments in dose lead to increasing intensity in response
Max effect = maximal response; once you increase the dose past maximum there is no increase
in response
ED 50 - answer✔Dose that results in 50% of the maximum effect
Dose that is effective in 50% of the population
Efficacy - answer✔The maximum response that can be produced by a drug
Potency - answer✔The strength of the drug
The amount that must be given in order to get a certain response
Therapeutic Range - answer✔The dose of a drug that keeps blood concentrations above the
minimum needed for a response but below the toxic response concentration
In between ineffective and toxic
Bioavailability - answer✔The fraction of the administered drug that enters the bloodstream (i.e.
100% for IV administration)
Absorption - answer✔Movement of a drug from site of administration to the blood
Distribution/Redistribution - answer✔Movement of a drug from blood to the site of action (i.e.
tissue)
Metabolism/Biotransformation - answer✔Conversion of a drug to a different chemical
compound; occurs mainly in the liver
Excretion - answer✔Moving a drug and its metabolites out of the body
Half Life - answer✔Time needed for the liver and kidney to remove half of the drug from the
body
Teratogenesis - answer✔Drug produces birth defects
Therapeutic Index (TI) - answer✔= TD50/ED50
Higher TI = Safer Drug
11/7/2024 12:35 PM
PHAR 100 Final Exam from Jud Study
Guide.
Codeine - answer✔0.5% opium
Pain relief
Morphine - answer✔10% opium
Immense pain reliever
Gold standard drug
Curare - answer✔Indigenous people dipped arrows, causing paralysis to animals
Paul Enrlich (father of chemo)
Gerhard Domagk
Alexander Fleming
Selman Waksman
Morton - answer✔Organoarsenicals--> syphilis
Sulfa drugs
Penicillin
Streptomyocin (TB)
Ether
Receptor - answer✔Molecule located on the inside or outside of a cell that has a regulatory role
in homeostasis
Agonists - answer✔Drugs that bind to a receptor and stimulate it
Antagonists - answer✔Drugs that bind to a receptor but block the response that it normally
elicits
, ©THEBRIGHT EXAM SOLUTIONS
11/7/2024 12:35 PM
Dose-Response Relationship - answer✔Intensity is proportional to dosage
Low dose = little response; not enough receptors activated
Threshold dose = enough receptors activated to elicit response
Past threshold = small increments in dose lead to increasing intensity in response
Max effect = maximal response; once you increase the dose past maximum there is no increase
in response
ED 50 - answer✔Dose that results in 50% of the maximum effect
Dose that is effective in 50% of the population
Efficacy - answer✔The maximum response that can be produced by a drug
Potency - answer✔The strength of the drug
The amount that must be given in order to get a certain response
Therapeutic Range - answer✔The dose of a drug that keeps blood concentrations above the
minimum needed for a response but below the toxic response concentration
In between ineffective and toxic
Bioavailability - answer✔The fraction of the administered drug that enters the bloodstream (i.e.
100% for IV administration)
Absorption - answer✔Movement of a drug from site of administration to the blood
Distribution/Redistribution - answer✔Movement of a drug from blood to the site of action (i.e.
tissue)
Metabolism/Biotransformation - answer✔Conversion of a drug to a different chemical
compound; occurs mainly in the liver
Excretion - answer✔Moving a drug and its metabolites out of the body
Half Life - answer✔Time needed for the liver and kidney to remove half of the drug from the
body
Teratogenesis - answer✔Drug produces birth defects
Therapeutic Index (TI) - answer✔= TD50/ED50
Higher TI = Safer Drug
