HEMATOLOGY HIRAL FULL ASCP
The light-colored zone adjacent to the nucleus in a plasmacyte is the:
A. ribosome
B. chormatin
C. mitochondira
D. Golgi area - answerD. Golgi area
The majority of the iron in an adult is found as a constituent of:
A. hemoglobin
B. hemosiderin
C. myglobin
D. transferrin - answerA. hemoglobin
The main function of the hexose monophosphate shunt in the erythrocyte is to:
A. regulate the level of 2,3-DPG
B. provide reduced glutathione to prevent oxidation of hemoglobin
C. prevent the reduction of heme iron
D. provide energy for membrane maintainance - answerB. provide reduced glutathione to
prevent oxidation of hemoglobin
Which curve represents the production of alpha polypeptide chains of hemoglobin?
A. A
B. B
C. C
D. D - answerB. B
Which curve represents the production of beta polypeptide chains of hemoglobin?
A. B
B. C
C. E
D. D - answerD. D
Which curve represents the production of gamma polypeptide chains of hemoglobin?
A. A
B. B
C. C
D. D - answerC. C
Which curve represents the production of delta polypeptide chains of hemoglobin?
A. B
B. C
C. D
D. E - answerD. E
Which curve represents the production of epsilon polypeptide chains of hemoglobin?
,A. A
B. B
C. C
D. D - answerA. A
In order for hemoglobin to combine reversibly with oxygen, the iron must be:
A. complexed with haptoglobin
B. freely circulating in the cytoplasm
C. attached to transferrin
D. in the ferrous state - answerD. in the ferrous state
In which of the following disease states are teardrop cells and abnormal PLTs most
characteristically seen?
A. hemolytic anemia
B. multiple myeloma
C. G-6-PD deficiency
D. myeloid metaplasia - answerD. myeloid metaplasia
In the normal adult, the spleen acts as a site for:
A. storage of RBCs
B. production of RBCs
C. synthesis of erythropoietin
D. removal of imperfect and aging cells - answerD. removal of imperfect and aging cells
After the removal of RBCs from the circulation hemoglobin is broken down into:
A. iron, porphyrin, and amino acids
B. iron, protoporphyrin, and glob in
C. heme, protoporphyrin, and amino acids
D. heme, hemosiderin, and globin - answerB. iron, protoporphyrin, and globin
Heinz bodies are:
A. readily identified with polychrome stains
B. rarely found in G6PD deficient erythrocytes
C. closely associated with spherocytes
D. denatured hemoglobin inclusions that are readily removed by the spleen - answerD.
denatured hemoglobin inclusions that are readily removed by the spleen
Cells for the transport of O2 and CO2 are:
A. erythrocytes
B. granulocytes
C. lymphocytes
D. thormbocytes - answerA. erythrocytes
Erythropoieten acts to:
A. shorten the replication of the granulocytes
B. stimulate RNA synthesis of erythroid cells
C. increase colony-stimulating factors produced by the B-lymphocytes
,D. decrease the release of marrow retics - answerB. stimulate RNA synthesis of erythroid
cells
What cell shape is MOST commonly associated with an increased MCHC?
A. teardrop cells
B. target cells
C. spherocytes
D. sickle cells - answerC. spherocytes
Which of the following characteristics are common to hereditary spherocytosis, hereditary
elliptocytosis, hereditary stomatocytosis, and paroxysmal nocturnal hemoglobinuria?
A. autosomal dominant inheritance
B. red cell membrane defects
C. positive direct antiglobulin test
D. meausre PLT count - answerB. red cell membrane defects
A patient is admitted with a history of chronic bleeding secondary to peptic ulcer.
Hematology workup reveals a severe microcytic, hypochromic anemia. Iron studies were
requested. Which of the following would be expected in this case? (chart on picture)
A. result A
B. result B
C. result C
D. results D - answerC. results C
Which of the following is MOST closely associated with iron deficient anemia?
A. iron overload in tissue
B. target cells
C. basophilic stippling
D. chronic blood loss - answerD. chronic blood loss
Evidence indicates the genetic defect in thalassemia usually results in:
A. the production of abnormal glob in chains
B. a quantitative deficiency in RNA resulting in decreased globin chain production
C. a structural change in the heme portion of the hemoglobin
D. an abnormality in the alpha- or beta-chain binding or affinity - answerB. a quantitative
deficiency in RNA resulting in decreased globin chain production
An enzyme deficiency associated with a moderate to sever hemolytic anemia after the
patient is exposed to certain drugs and characterized by red cell inclusions from by
denatured hemoglobin is:
A. lactate dehydrogenase deficiency
B. G-6-PD deficiency
C. pyruvate kinase deficiency
D. hexokinase deficiency - answerB. G-6-PD deficiency
Patients with A(-) type G6PD deficiency are LEAST likely to have hemolytic episodes in which
of the following situations?
A. following the administration of oxidizing drugs
, B. following the ingestion of fava beans
C. during infections
D. spontaneously - answerD. spontaneously
A patient has a congenital nonspherocytic hemolytic anemia. After exposure to anti-malarial
drugs the patient experiences a severe hemolytic episode. This episode is characterized by
red cell inclusions caused by hemoglobin denaturation. Which of the following conditions is
MOST consistent with these findings?
A. G6PD deficiency
B. thalassemia major
C. pyruvate kinase deficiency
D. paroxysmal nocturnal hemoglobinuria - answerA. G6PD deficiency
Peripheral blood smears from patients with untreated pernicious anemia are characterized
by:
A. pancytopenia and macrocytosis
B. leukocytosis and elliptocytosis
C. leukocytosis and ovalocytosis
D. pancytopenia and microcytosis - answerA. pancytopenia and macrocytosis
Lab tests preformed on a patient indicate macrocytosis, anemia, leukopenia and
throbocytopenia. Which of the following disorders is the patient most likely to have?
A. anemia of chronic disorder
B. vitamin B12 deficiency
C. iron deficiency
D. acute hemorrhage - answerB. vitamin B12 deficiency
The characteristic morphologic feature in folic acid deficiency is:
A. macrocytosis
B. target cells
C. serum B12 and folate
D. leukocyte alkaline phosphatase - answerA. macrocytosis
The most likely cause of the macrocytosis that often accompanies anemia of myelofibrosis
is:
A. folic acid deficiency
B. increased retic count
C. inadequate B12 absorption
D. pryidoxine deficiency - answerA. folic acid deficiency
Which of the following represents characteristics features of iron metabolism in patients with
anemia of chronic disorder?
A. result A
B. result B
C. result C
D. result D - answerD. result D
A characteristic morphologic feature in hemoglobin C disease is:
The light-colored zone adjacent to the nucleus in a plasmacyte is the:
A. ribosome
B. chormatin
C. mitochondira
D. Golgi area - answerD. Golgi area
The majority of the iron in an adult is found as a constituent of:
A. hemoglobin
B. hemosiderin
C. myglobin
D. transferrin - answerA. hemoglobin
The main function of the hexose monophosphate shunt in the erythrocyte is to:
A. regulate the level of 2,3-DPG
B. provide reduced glutathione to prevent oxidation of hemoglobin
C. prevent the reduction of heme iron
D. provide energy for membrane maintainance - answerB. provide reduced glutathione to
prevent oxidation of hemoglobin
Which curve represents the production of alpha polypeptide chains of hemoglobin?
A. A
B. B
C. C
D. D - answerB. B
Which curve represents the production of beta polypeptide chains of hemoglobin?
A. B
B. C
C. E
D. D - answerD. D
Which curve represents the production of gamma polypeptide chains of hemoglobin?
A. A
B. B
C. C
D. D - answerC. C
Which curve represents the production of delta polypeptide chains of hemoglobin?
A. B
B. C
C. D
D. E - answerD. E
Which curve represents the production of epsilon polypeptide chains of hemoglobin?
,A. A
B. B
C. C
D. D - answerA. A
In order for hemoglobin to combine reversibly with oxygen, the iron must be:
A. complexed with haptoglobin
B. freely circulating in the cytoplasm
C. attached to transferrin
D. in the ferrous state - answerD. in the ferrous state
In which of the following disease states are teardrop cells and abnormal PLTs most
characteristically seen?
A. hemolytic anemia
B. multiple myeloma
C. G-6-PD deficiency
D. myeloid metaplasia - answerD. myeloid metaplasia
In the normal adult, the spleen acts as a site for:
A. storage of RBCs
B. production of RBCs
C. synthesis of erythropoietin
D. removal of imperfect and aging cells - answerD. removal of imperfect and aging cells
After the removal of RBCs from the circulation hemoglobin is broken down into:
A. iron, porphyrin, and amino acids
B. iron, protoporphyrin, and glob in
C. heme, protoporphyrin, and amino acids
D. heme, hemosiderin, and globin - answerB. iron, protoporphyrin, and globin
Heinz bodies are:
A. readily identified with polychrome stains
B. rarely found in G6PD deficient erythrocytes
C. closely associated with spherocytes
D. denatured hemoglobin inclusions that are readily removed by the spleen - answerD.
denatured hemoglobin inclusions that are readily removed by the spleen
Cells for the transport of O2 and CO2 are:
A. erythrocytes
B. granulocytes
C. lymphocytes
D. thormbocytes - answerA. erythrocytes
Erythropoieten acts to:
A. shorten the replication of the granulocytes
B. stimulate RNA synthesis of erythroid cells
C. increase colony-stimulating factors produced by the B-lymphocytes
,D. decrease the release of marrow retics - answerB. stimulate RNA synthesis of erythroid
cells
What cell shape is MOST commonly associated with an increased MCHC?
A. teardrop cells
B. target cells
C. spherocytes
D. sickle cells - answerC. spherocytes
Which of the following characteristics are common to hereditary spherocytosis, hereditary
elliptocytosis, hereditary stomatocytosis, and paroxysmal nocturnal hemoglobinuria?
A. autosomal dominant inheritance
B. red cell membrane defects
C. positive direct antiglobulin test
D. meausre PLT count - answerB. red cell membrane defects
A patient is admitted with a history of chronic bleeding secondary to peptic ulcer.
Hematology workup reveals a severe microcytic, hypochromic anemia. Iron studies were
requested. Which of the following would be expected in this case? (chart on picture)
A. result A
B. result B
C. result C
D. results D - answerC. results C
Which of the following is MOST closely associated with iron deficient anemia?
A. iron overload in tissue
B. target cells
C. basophilic stippling
D. chronic blood loss - answerD. chronic blood loss
Evidence indicates the genetic defect in thalassemia usually results in:
A. the production of abnormal glob in chains
B. a quantitative deficiency in RNA resulting in decreased globin chain production
C. a structural change in the heme portion of the hemoglobin
D. an abnormality in the alpha- or beta-chain binding or affinity - answerB. a quantitative
deficiency in RNA resulting in decreased globin chain production
An enzyme deficiency associated with a moderate to sever hemolytic anemia after the
patient is exposed to certain drugs and characterized by red cell inclusions from by
denatured hemoglobin is:
A. lactate dehydrogenase deficiency
B. G-6-PD deficiency
C. pyruvate kinase deficiency
D. hexokinase deficiency - answerB. G-6-PD deficiency
Patients with A(-) type G6PD deficiency are LEAST likely to have hemolytic episodes in which
of the following situations?
A. following the administration of oxidizing drugs
, B. following the ingestion of fava beans
C. during infections
D. spontaneously - answerD. spontaneously
A patient has a congenital nonspherocytic hemolytic anemia. After exposure to anti-malarial
drugs the patient experiences a severe hemolytic episode. This episode is characterized by
red cell inclusions caused by hemoglobin denaturation. Which of the following conditions is
MOST consistent with these findings?
A. G6PD deficiency
B. thalassemia major
C. pyruvate kinase deficiency
D. paroxysmal nocturnal hemoglobinuria - answerA. G6PD deficiency
Peripheral blood smears from patients with untreated pernicious anemia are characterized
by:
A. pancytopenia and macrocytosis
B. leukocytosis and elliptocytosis
C. leukocytosis and ovalocytosis
D. pancytopenia and microcytosis - answerA. pancytopenia and macrocytosis
Lab tests preformed on a patient indicate macrocytosis, anemia, leukopenia and
throbocytopenia. Which of the following disorders is the patient most likely to have?
A. anemia of chronic disorder
B. vitamin B12 deficiency
C. iron deficiency
D. acute hemorrhage - answerB. vitamin B12 deficiency
The characteristic morphologic feature in folic acid deficiency is:
A. macrocytosis
B. target cells
C. serum B12 and folate
D. leukocyte alkaline phosphatase - answerA. macrocytosis
The most likely cause of the macrocytosis that often accompanies anemia of myelofibrosis
is:
A. folic acid deficiency
B. increased retic count
C. inadequate B12 absorption
D. pryidoxine deficiency - answerA. folic acid deficiency
Which of the following represents characteristics features of iron metabolism in patients with
anemia of chronic disorder?
A. result A
B. result B
C. result C
D. result D - answerD. result D
A characteristic morphologic feature in hemoglobin C disease is:
