Renal Micro
, Urinary Tract Infections Lower UTI
Upper UTI
of
Pathogenesis UTI
1 .
Contamination of
periurethral area wh uropathoge from gut 6. Biofilm formation
.
2 Colonisation of Wethra B
migration to bladde .
7 Epithelial damage by bacterial toxing & proteases
.
3 Colonisation & invasion of bladder-mediated
by pili B adhesing 8 .
Ascention to
Kidney & Colonisation
4.
Neutrophil infiltration 9
. Host tissue
damage by bacterial toxins
.
5 Bacterial multiplication immune subversion 10 . Bacter demia
system
Bacterial adherence wroepithelium
Key pathogenesis
* in UTF :
to
Portals of
Entry
Ascending rouze
Haematogenous route
ascending infyn via we thre
frequently following renal
bacter aerial endocarditis
· ·
most common more
likely than
cause abscess UTI
·
·
to
bladder ascend venal pelvis extension
in
multiply into ureters,
parenchyma Direct
·
may
once
,
intx maintains residual of infected bladder aler
contiguous spread from nearby infective process pelvic pendicial Listula
perpetuous pool wine in
voiding abscess
· : ·
: a
, , ,
Host
Susceptibility &
Predisposing factors Microbial Virulence factors
pili adhesing Limbriae formation
Age Adherence Biofilm
· · ·
: ,
,
Sex 2 M
laye 1 50 Toxing
Motility Flagella
·
·
: > -
·
:
↳ M > F (under 1; 350) ·
Immune evasion :
capsule eneynes·
,
Calculus formation
anatomical) functional abnormalities acquisition molecules
splitting bacteria
·
·
Fron · Urea
·
foreign bodies L
Underlying congenizal Corynebacterium Wrealyticum Protens sp (miribalis Vulgaris)
· ·
.
,
structural abnormalities ·
Split areaforms ammonium
a ↑
urinary put .
·
Chronic Disease · facilitates formation of struvite calculi
Mechanical factors
pl ↑ calculi become less soluble
·
·
as
Inadequate bladder emptying production facilitates renal formation
·
wease stone
Antibacterial host defensed in Tract
Urinary
of bacterial adherence
wine
Dosmolality BpH Urinary inhibitors
·
·
:
flow mictrition
wine a
protein mucopolysaccharide digosaccharides
· -
, ,
Urinary tract mucosa
Secretory Immunoglobulin
A
·
: -
bactericidal of epithelial cells· Prostatic
activity--recharge
-
Secretions
-Antimicrobial peptides of
length urethra
·
Regula Complete bladder emptying location of thral
opening
·
we
, Urinary Tract Infections Lower UTI
Upper UTI
of
Pathogenesis UTI
1 .
Contamination of
periurethral area wh uropathoge from gut 6. Biofilm formation
.
2 Colonisation of Wethra B
migration to bladde .
7 Epithelial damage by bacterial toxing & proteases
.
3 Colonisation & invasion of bladder-mediated
by pili B adhesing 8 .
Ascention to
Kidney & Colonisation
4.
Neutrophil infiltration 9
. Host tissue
damage by bacterial toxins
.
5 Bacterial multiplication immune subversion 10 . Bacter demia
system
Bacterial adherence wroepithelium
Key pathogenesis
* in UTF :
to
Portals of
Entry
Ascending rouze
Haematogenous route
ascending infyn via we thre
frequently following renal
bacter aerial endocarditis
· ·
most common more
likely than
cause abscess UTI
·
·
to
bladder ascend venal pelvis extension
in
multiply into ureters,
parenchyma Direct
·
may
once
,
intx maintains residual of infected bladder aler
contiguous spread from nearby infective process pelvic pendicial Listula
perpetuous pool wine in
voiding abscess
· : ·
: a
, , ,
Host
Susceptibility &
Predisposing factors Microbial Virulence factors
pili adhesing Limbriae formation
Age Adherence Biofilm
· · ·
: ,
,
Sex 2 M
laye 1 50 Toxing
Motility Flagella
·
·
: > -
·
:
↳ M > F (under 1; 350) ·
Immune evasion :
capsule eneynes·
,
Calculus formation
anatomical) functional abnormalities acquisition molecules
splitting bacteria
·
·
Fron · Urea
·
foreign bodies L
Underlying congenizal Corynebacterium Wrealyticum Protens sp (miribalis Vulgaris)
· ·
.
,
structural abnormalities ·
Split areaforms ammonium
a ↑
urinary put .
·
Chronic Disease · facilitates formation of struvite calculi
Mechanical factors
pl ↑ calculi become less soluble
·
·
as
Inadequate bladder emptying production facilitates renal formation
·
wease stone
Antibacterial host defensed in Tract
Urinary
of bacterial adherence
wine
Dosmolality BpH Urinary inhibitors
·
·
:
flow mictrition
wine a
protein mucopolysaccharide digosaccharides
· -
, ,
Urinary tract mucosa
Secretory Immunoglobulin
A
·
: -
bactericidal of epithelial cells· Prostatic
activity--recharge
-
Secretions
-Antimicrobial peptides of
length urethra
·
Regula Complete bladder emptying location of thral
opening
·
we
