MGY277 UNIT 7 EXAM QUESTIONS AND
COMPLETE ANSWERS
Match the antimicrobial with its direct target:
ampicillin; cephalosporin; carbapenem; vancomycin; tobramycin; sulfa drug;
trimethoprim; fluoroquinolone; tetracycline; rifamycins; macrolides
penicillin binding protein; peptidoglycan wall peptide; 30S ribosomal subunit; first
enzyme in folic acid biosynthesis; third enzyme in folic acid biosynthesis; DNA gyrase;
RNA polymerase; 50S subunit - Answer ampicillin --> penicillin binding protein
cephalosporin --> penicillin binding protein
carbapenem --> penicillin binding protein
vancomycin --> peptidoglycan wall peptide
tobramycin --> 30S ribosomal subunit
sulfa drug --> first enzyme in folic acid biosynthesis
trimethoprim --> third enzyme in folic acid biosynthesis
fluoroquinolone --> DNA gyrase
tetracycline --> 30S ribosomal subunit
rifamycins --> RNA polymerase
macrolides --> 50S subunit
Antibiotics that are most likely to disrupt the normal flora are termed: - Answer
broad-spectrum
Beta-lactamases:
1. bind to penicillin-binding proteins.
2. break the beta-lactam ring.
3. bind to peptides.
4. prevent the linking of glycan chains in peptidoglycan. - Answer 2. break the
beta-lactam ring.
The first example of an antimicrobial drug synthesized in the laboratory was - Answer
Salvarsan
Trimethoprim alters bacterial metabolism by - Answer blocking folic acid synthesis
COMPLETE ANSWERS
Match the antimicrobial with its direct target:
ampicillin; cephalosporin; carbapenem; vancomycin; tobramycin; sulfa drug;
trimethoprim; fluoroquinolone; tetracycline; rifamycins; macrolides
penicillin binding protein; peptidoglycan wall peptide; 30S ribosomal subunit; first
enzyme in folic acid biosynthesis; third enzyme in folic acid biosynthesis; DNA gyrase;
RNA polymerase; 50S subunit - Answer ampicillin --> penicillin binding protein
cephalosporin --> penicillin binding protein
carbapenem --> penicillin binding protein
vancomycin --> peptidoglycan wall peptide
tobramycin --> 30S ribosomal subunit
sulfa drug --> first enzyme in folic acid biosynthesis
trimethoprim --> third enzyme in folic acid biosynthesis
fluoroquinolone --> DNA gyrase
tetracycline --> 30S ribosomal subunit
rifamycins --> RNA polymerase
macrolides --> 50S subunit
Antibiotics that are most likely to disrupt the normal flora are termed: - Answer
broad-spectrum
Beta-lactamases:
1. bind to penicillin-binding proteins.
2. break the beta-lactam ring.
3. bind to peptides.
4. prevent the linking of glycan chains in peptidoglycan. - Answer 2. break the
beta-lactam ring.
The first example of an antimicrobial drug synthesized in the laboratory was - Answer
Salvarsan
Trimethoprim alters bacterial metabolism by - Answer blocking folic acid synthesis
