Electroencephalographic (EEG)
Recording and Epilepsy Exam
Epilepsy ii- iiAnswers ii-Recurrent iiseizures
-Problem iiusually iiwith ii*medial iitemporal iilobe-> iiHippocamus* ii
-2nd iimost iicommon iineurological iiproblem iiafter iistroke
EEG ii- iiAnswers ii-* iiElectroencephalogram*
-The iicollective iielectrical iiactivity iiof iithe iineurons iiin iithe iicortex ii(pyramidal iicells) iican
iibe iimeasured.
-The iiactivity iiof iithe iicortical iineurons iichanges iiin iiresponse iito iibehavioral iistates iiand ii
pathologies iisuch iias ii*coma iiand iiepilepsy* ii
-EEG iiis iiimportant iiin iithe iiclinical iiassessment iiof ii
*cortical iifunction*
-Brain iielectrical iiactivity iichanged iiwith ii*sleep iior iialtered iiattention*
Where iidoes iiEEG iicome iifrom? ii- iiAnswers ii-*Extracellular iifield iipotential ii(ECFP)* iiin
iithe iiISF ii(brain iiinterstitial iifluid)
-There iiare ii100s iiof iithese iithat iiget iiSUMMATED iitogether iito iihave iia iirecording iiyou
iirecognize ii(EEG)
EEG iiof iiseizure ii- iiAnswers ii-Position iiof iirecording iielectrode ii(location iiof iielectrode
iithat iimeasures iiVOLTAGE) iivs. iiOnset iiof iiseizure ii(time) ii
-Where iiis iithe iielectrode iiand iiwhere iiare iiyou iimonitoring iithe iibrain?
>Each iielect iiode iiis iimonitoring iiactivity iibetween ii2 iilocations
>F= iiFrontal
>Fp= iiPre-Frontal
>C= iiCentral iisulcus
>P= iiParietal
>O= iiOccipital ii
-From iiT=0 iito iiT=1: iiEEG iiamplitude iiis iifairly iiLOW
-After iiT=1: iiSee iiamplitude iion iievery iichannel iiis iihuge= iiSPIKES
, -Red iiline iion iigraph iiindicates iiABNORMAL iielectrical iiactivity iion iiright iiand iileft
iihemispheres iifrom iifront iito iiback= ii*Grand iiMal iiSeizure*: iiActing iion iiALL iichannels iiat
iian iiinstant iiof iitime
>Generalized iiseizure ii
-Odd ii#: iiLeft iiside
-Even ii#: iiRight iiside
-Certain iiarrangements= iiMONTAGE
Generation iiof iiextracellular iifield iipotentials ii(ECFP) ii- iiAnswers ii--Primary
iitransmembranous ii(synaptic) iicurrents ii(both iiinward iiand iioutward) ii
generate iisecondary iiionic iicurrents iialong iithe iicell iimembranes iiin iiboth iithe iiintra- iiand
iiextracellular iispaces ii(release iitransmitter)
-Single iineuron iielectrical iiactivity iiCANNOT iibe iirecorded iifrom iithe iiscalp ii(ECFP iiNOT
iimeasuring iione iineuron) ii
-Scalp iirecording iiis iithe iisummed iiextracellular iifield iipotentials iiof iilarge iinumbers iiof
iineurons. ii
-ECFPs iiare iiSLOWER iithan iiaction iipotentials iiand iican
SUMMATE
-The iiportion iiof iithe iicurrent iithat iiflows iithrough iithe iiextracellular iispace iiis iidirectly ii
responsible iifor iithe iigeneration iiof ii"extracellular iifield iipotentials" iirecorded iiat ii
the iiscalp iias iiEEG. ii
-Scalp iirecordings iidepend iion iithe iidepth iiof iisynaptic iiactivity iiand iithe iitype iiof ii
stimulation ii(IPSP iior iiEPSP)
-NEGATIVE iior iiPOSITIVE iiextracellular iifield iipotentials
NEGATIVE iiextracellular iifield iipotentials ii- iiAnswers ii-Recorded iiat iithe iiscalp iias ii
*UPWARD iiEEG iideflections* ii
-Current iiflow iiis iiinward ii*"sink"* iiand iiNEGATIVE ii
near iithe iiscalp.
POSITIVE iiextracellular iifield iipotentials ii- iiAnswers ii-Extracellular iifield iipotentials iiare
iirecorded iiat iithe iiscalp iias ii
*DOWNWARD iiEEG iideflections* ii
-Current iiflow iiis iioutward ii*"source"* iiand ii
POSITIVE iinear iithe iiscalp
Recording and Epilepsy Exam
Epilepsy ii- iiAnswers ii-Recurrent iiseizures
-Problem iiusually iiwith ii*medial iitemporal iilobe-> iiHippocamus* ii
-2nd iimost iicommon iineurological iiproblem iiafter iistroke
EEG ii- iiAnswers ii-* iiElectroencephalogram*
-The iicollective iielectrical iiactivity iiof iithe iineurons iiin iithe iicortex ii(pyramidal iicells) iican
iibe iimeasured.
-The iiactivity iiof iithe iicortical iineurons iichanges iiin iiresponse iito iibehavioral iistates iiand ii
pathologies iisuch iias ii*coma iiand iiepilepsy* ii
-EEG iiis iiimportant iiin iithe iiclinical iiassessment iiof ii
*cortical iifunction*
-Brain iielectrical iiactivity iichanged iiwith ii*sleep iior iialtered iiattention*
Where iidoes iiEEG iicome iifrom? ii- iiAnswers ii-*Extracellular iifield iipotential ii(ECFP)* iiin
iithe iiISF ii(brain iiinterstitial iifluid)
-There iiare ii100s iiof iithese iithat iiget iiSUMMATED iitogether iito iihave iia iirecording iiyou
iirecognize ii(EEG)
EEG iiof iiseizure ii- iiAnswers ii-Position iiof iirecording iielectrode ii(location iiof iielectrode
iithat iimeasures iiVOLTAGE) iivs. iiOnset iiof iiseizure ii(time) ii
-Where iiis iithe iielectrode iiand iiwhere iiare iiyou iimonitoring iithe iibrain?
>Each iielect iiode iiis iimonitoring iiactivity iibetween ii2 iilocations
>F= iiFrontal
>Fp= iiPre-Frontal
>C= iiCentral iisulcus
>P= iiParietal
>O= iiOccipital ii
-From iiT=0 iito iiT=1: iiEEG iiamplitude iiis iifairly iiLOW
-After iiT=1: iiSee iiamplitude iion iievery iichannel iiis iihuge= iiSPIKES
, -Red iiline iion iigraph iiindicates iiABNORMAL iielectrical iiactivity iion iiright iiand iileft
iihemispheres iifrom iifront iito iiback= ii*Grand iiMal iiSeizure*: iiActing iion iiALL iichannels iiat
iian iiinstant iiof iitime
>Generalized iiseizure ii
-Odd ii#: iiLeft iiside
-Even ii#: iiRight iiside
-Certain iiarrangements= iiMONTAGE
Generation iiof iiextracellular iifield iipotentials ii(ECFP) ii- iiAnswers ii--Primary
iitransmembranous ii(synaptic) iicurrents ii(both iiinward iiand iioutward) ii
generate iisecondary iiionic iicurrents iialong iithe iicell iimembranes iiin iiboth iithe iiintra- iiand
iiextracellular iispaces ii(release iitransmitter)
-Single iineuron iielectrical iiactivity iiCANNOT iibe iirecorded iifrom iithe iiscalp ii(ECFP iiNOT
iimeasuring iione iineuron) ii
-Scalp iirecording iiis iithe iisummed iiextracellular iifield iipotentials iiof iilarge iinumbers iiof
iineurons. ii
-ECFPs iiare iiSLOWER iithan iiaction iipotentials iiand iican
SUMMATE
-The iiportion iiof iithe iicurrent iithat iiflows iithrough iithe iiextracellular iispace iiis iidirectly ii
responsible iifor iithe iigeneration iiof ii"extracellular iifield iipotentials" iirecorded iiat ii
the iiscalp iias iiEEG. ii
-Scalp iirecordings iidepend iion iithe iidepth iiof iisynaptic iiactivity iiand iithe iitype iiof ii
stimulation ii(IPSP iior iiEPSP)
-NEGATIVE iior iiPOSITIVE iiextracellular iifield iipotentials
NEGATIVE iiextracellular iifield iipotentials ii- iiAnswers ii-Recorded iiat iithe iiscalp iias ii
*UPWARD iiEEG iideflections* ii
-Current iiflow iiis iiinward ii*"sink"* iiand iiNEGATIVE ii
near iithe iiscalp.
POSITIVE iiextracellular iifield iipotentials ii- iiAnswers ii-Extracellular iifield iipotentials iiare
iirecorded iiat iithe iiscalp iias ii
*DOWNWARD iiEEG iideflections* ii
-Current iiflow iiis iioutward ii*"source"* iiand ii
POSITIVE iinear iithe iiscalp