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Nur 617 Pharm Exam 1 Questions and
Correct Answers the Latest Update
Pharmacogenomics
✓ the study of genetically determined variations in the response to drugs
Pharmacokinetics
✓ The way the body processes drugs. Involves 4 processes of:
✓ -absorption
✓ -distribution
✓ -metabolism
✓ -excretion
Drug clearance
✓ The process of metabolism and excretion/
✓ The disappearance of the drug from the patient's serum
Absorption
✓ The process by which drug molecules move from their site of administration, across
one or more cell membranes, in order to gain entry to the blood
Driving force of absorption
✓ Concentration gradient = Concentration on either side of the membrane
Concentration Gradient
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✓ Passive diffusion- from high concentration to low concentration. Does NOT require
energy
Routes of drug administration that do NOT involve the absorption process
✓ -IV
✓ -Intraarterial
Absorption: Fastest to slowest drug formulations
✓ FASTEST
✓ -liquids
✓ -suspensions
✓ -powders
✓
✓ -capsules
✓ -tablets
✓ -enteric coated tablets
✓ -sustained release tablets
✓ SLOWEST
Factors that determine the rate and extent of drug absorption
✓ -solubility (or dissolvability) of the drug
✓ -physical properties of the drug
✓ -area of absorptive surface
✓ -blood supply at absorptive surface
✓ -length of time of contact with absorptive surface
Cell membranes are composed of lipids. --> Fat-soluble molecules cross the
membrane easier than water-soluble. What are fat soluble molecules called?
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