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Nur 617 Pharm Exam 1 Questions and Correct Answers the Latest Update

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Pharmacogenomics the study of genetically determined variations in the response to drugs Pharmacokinetics The way the body processes drugs. Involves 4 processes of: -absorption -distribution -metabolism -excretion Drug clearance The process of metabolism and excretion/ The disappearance of the drug from the patient's serum Absorption The process by which drug molecules move from their site of administration, across one or more cell membranes, in order to gain entry to the blood Driving force of absorption Concentration gradient = Concentration on either side of the membrane Concentration Gradient #Examify | #OnlineExams | #TestPrep | #StudyResources | #AcademicSuccess | #ExamPreparation | #QuizTime | #LearningTools | #Education | #StudentSupport Examify | Smart Grades | Latest update 1 Passive diffusion- from high concentration to low concentration. Does NOT require energy Routes of drug administration that do NOT involve the absorption process -IV -Intraarterial Absorption: Fastest to slowest drug formulations FASTEST -liquids -suspensions -powders -capsules -tablets -enteric coated tablets -sustained release tablets SLOWEST Factors that determine the rate and extent of drug absorption -solubility (or dissolvability) of the drug -physical properties of the drug -area of absorptive surface -blood supply at absorptive surface -length of time of contact with absorptive surface Cell membranes are composed of lipids. -- Fat-soluble molecules cross the membrane easier than water-soluble. What are fat soluble molecules called? #Examify | #OnlineExams | #TestPrep | #StudyResources | #AcademicSuccess | #ExamPreparation | #QuizTime | #LearningTools | #Education | #StudentSupport Examify | Smart Grades | Latest update 1 Non-ionized Non-polarized ***Acidic Water soluble molecules Ionized Polarized ***basic Drugs which are highly ionized or highly lipophilic (water-loving) both have a hard time being absorbed. It is better to be weaker Weak acid drugs -phenobarbital -pentobarbital -acetaminophen

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Nur 617
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Nur 617 Pharm Exam 1 Questions and
Correct Answers the Latest Update
Pharmacogenomics

✓ the study of genetically determined variations in the response to drugs



Pharmacokinetics

✓ The way the body processes drugs. Involves 4 processes of:
✓ -absorption
✓ -distribution
✓ -metabolism
✓ -excretion



Drug clearance

✓ The process of metabolism and excretion/
✓ The disappearance of the drug from the patient's serum



Absorption

✓ The process by which drug molecules move from their site of administration, across
one or more cell membranes, in order to gain entry to the blood



Driving force of absorption

✓ Concentration gradient = Concentration on either side of the membrane



Concentration Gradient




Examify | Smart Grades | Latest update
1

, #Examify | #OnlineExams | #TestPrep | #StudyResources | #AcademicSuccess |
#ExamPreparation | #QuizTime | #LearningTools | #Education | #StudentSupport

✓ Passive diffusion- from high concentration to low concentration. Does NOT require
energy



Routes of drug administration that do NOT involve the absorption process

✓ -IV
✓ -Intraarterial



Absorption: Fastest to slowest drug formulations

✓ FASTEST
✓ -liquids
✓ -suspensions
✓ -powders

✓ -capsules
✓ -tablets
✓ -enteric coated tablets
✓ -sustained release tablets
✓ SLOWEST



Factors that determine the rate and extent of drug absorption

✓ -solubility (or dissolvability) of the drug
✓ -physical properties of the drug
✓ -area of absorptive surface
✓ -blood supply at absorptive surface
✓ -length of time of contact with absorptive surface



Cell membranes are composed of lipids. --> Fat-soluble molecules cross the

membrane easier than water-soluble. What are fat soluble molecules called?



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Nur 617
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Subido en
21 de octubre de 2024
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