UNE Medical Biochemistry Unit 1 Test
Questions And Answers Graded A+.
Changes in the physiological variables listed below can alter the affinity of hemoglobin
for oxygen. Which of the following will lower the affinity of hemoglobin for oxygen?
a) decrease in protons
b) increase in 2,3 bisphosphoglycerate (BPG)
c) increase in pH
d) decrease in CO2 - correct answer. Increase in 2,3 bisphosphoglycerate (BPG)
Domains are common structural elements that retain a particular function within the
protein. Which of the following is an example of a protein domain?
a) a prosthetic group such as heme
b) irregular coils and loops
c) an arrangement of β-strands connected by α- helixes
d) a single α- helix - correct answer. An arrangement of β-strands connected by α-
helixes
A 22-year-old female is diagnosed with acute pancreatitis. Elevation of which of the
following serum enzymes would be consistent with this diagnosis?
a) lactate dehydrogenase
b) amylase
c) troponin
d) creatine kinase - correct answer. amylase
Movement of ammonia from an amino acid to an alpha-keto acid involves a family of
enzymes best categorized as:
a) transferases
b) ligases
c) lyases
d) isomerases - correct answer. transferases
, Which of the following proteins is likely to have quaternary structure?
a) a protein that contains both α-helix and β-sheet secondary structures
b) a multimeric protein that contains multiple peptide chains
c) a small protein consisting of a single amino acid chain
d) a large transmemberane protein with seven alpha helical domains - correct answer.
a multimeric protein that contains multiple peptide chains
Cleavage of fructose 1, 6 bisphosphate to dihydroxyacetone and glyceraldehyde 3-
phosphate is achieved by what class of enzymes?
a) ligase
b) lyase
c) transferase
d) hydrolase - correct answer. Lyase
Which of the following best describes the structure of heme?
a) a planar porphyrin ring that binds iron
b) a nicotinamide structure that is readily oxidized
c) an n-linked glycosylation
d) a negatively charged phosphate group - correct answer. a planar porphyrin ring
that binds iron
Prosthetic groups are complex nonprotein molecules that participate in catalysis by
providing functional groups that form a covalent intermediate between the enzyme and
the substrate. Which of the following is an example of a coenzyme or cofactor that
participates in a covalent catalysis reaction?
a) ATP
b) OH-
c) NADH
d) pyridoxal phosphate - correct answer. pyridoxal phsophate
Which of the following best describes tertiary structure?
a) interactions between differing subunits of a protein
b) interactions between α-helixes and β-pleated sheets to form a domain
c) interactions between amino acids 4 residues away from each other
d) interactions between single amino acids adjacent to one another - correct answer.
interactions between α-helixes and β-pleated sheets to form a domain
Hemoglobin bound to heme is termed a holoprotein. The heme is required for oxygen
binding and is defined as which of the following?
a) apoprotein
Questions And Answers Graded A+.
Changes in the physiological variables listed below can alter the affinity of hemoglobin
for oxygen. Which of the following will lower the affinity of hemoglobin for oxygen?
a) decrease in protons
b) increase in 2,3 bisphosphoglycerate (BPG)
c) increase in pH
d) decrease in CO2 - correct answer. Increase in 2,3 bisphosphoglycerate (BPG)
Domains are common structural elements that retain a particular function within the
protein. Which of the following is an example of a protein domain?
a) a prosthetic group such as heme
b) irregular coils and loops
c) an arrangement of β-strands connected by α- helixes
d) a single α- helix - correct answer. An arrangement of β-strands connected by α-
helixes
A 22-year-old female is diagnosed with acute pancreatitis. Elevation of which of the
following serum enzymes would be consistent with this diagnosis?
a) lactate dehydrogenase
b) amylase
c) troponin
d) creatine kinase - correct answer. amylase
Movement of ammonia from an amino acid to an alpha-keto acid involves a family of
enzymes best categorized as:
a) transferases
b) ligases
c) lyases
d) isomerases - correct answer. transferases
, Which of the following proteins is likely to have quaternary structure?
a) a protein that contains both α-helix and β-sheet secondary structures
b) a multimeric protein that contains multiple peptide chains
c) a small protein consisting of a single amino acid chain
d) a large transmemberane protein with seven alpha helical domains - correct answer.
a multimeric protein that contains multiple peptide chains
Cleavage of fructose 1, 6 bisphosphate to dihydroxyacetone and glyceraldehyde 3-
phosphate is achieved by what class of enzymes?
a) ligase
b) lyase
c) transferase
d) hydrolase - correct answer. Lyase
Which of the following best describes the structure of heme?
a) a planar porphyrin ring that binds iron
b) a nicotinamide structure that is readily oxidized
c) an n-linked glycosylation
d) a negatively charged phosphate group - correct answer. a planar porphyrin ring
that binds iron
Prosthetic groups are complex nonprotein molecules that participate in catalysis by
providing functional groups that form a covalent intermediate between the enzyme and
the substrate. Which of the following is an example of a coenzyme or cofactor that
participates in a covalent catalysis reaction?
a) ATP
b) OH-
c) NADH
d) pyridoxal phosphate - correct answer. pyridoxal phsophate
Which of the following best describes tertiary structure?
a) interactions between differing subunits of a protein
b) interactions between α-helixes and β-pleated sheets to form a domain
c) interactions between amino acids 4 residues away from each other
d) interactions between single amino acids adjacent to one another - correct answer.
interactions between α-helixes and β-pleated sheets to form a domain
Hemoglobin bound to heme is termed a holoprotein. The heme is required for oxygen
binding and is defined as which of the following?
a) apoprotein
