NAPLEX antibiotics 212 Questions with 100%
Correct Answers | Verified | Updated 2024
MIC - ANSWER>>lowest drug concentration that prevents visibile microbial growth in
24 hours
What type of killing do carbapenems exhibit? - ANSWER>>time-dependent bactericidal
gram (+) bacteria species - ANSWER>>staph, strep, EC, clostridium, listeria
which antibiotics exhibit time-dependent killing? - ANSWER>>penicillins,
cephalosporins
how can you increase the killing of a time-dependent antibiotic? - ANSWER>>dose
more frequently, extend the infusion time
example of concentration-dependent antibiotic? - ANSWER>>aminoglycosides
(gentamicin, tobramycin, amikacin)
what are the bacteriostatic antibiotics (protein synthesis inhibitors)? -
ANSWER>>macrolides
aminoglycosides
tetracyclines
clindamycin
linezolid
quinupristin, dalfopristin
what is the MOA of penicillins, cephalosporins, carbapenems, and vancomycin? -
ANSWER>>cell wall inhibitors - bactericidal
,what general ADRs are the black box warning for aminoglycosides? -
ANSWER>>nephrotoxicity and neurotoxicity
what are the aminoglycosides? - ANSWER>>tobramycin
gentamicin
amikacin
what is the ratio of sulfamethoxazole to trimethoprim? - ANSWER>>always 5:1
what enzyme do sulfonamides inhibit? DI? - ANSWER>>2C8/9 - warfarin
what type of nephrotoxicity do aminoglycosides cause? - ANSWER>>ATN - acute
tubular necrosis
what weight do you use to dose aminoglycosides? - ANSWER>>IBW (unless TBW is
less)
*use ABW if obese ( > 30% IBW)
what organisms are aminoglycosides mainly active against? - ANSWER>>gram (-):
GNR, PA
extended interval dosing of the aminoglycosides? - ANSWER>>gent/tobra: 4-7 mg/kg
amikacin: 15-20 mg/kg
*draw random level within 6-16 hours after dose
adjust body weight (ABW) formula? - ANSWER>>IBW + [0.4(TBW - IBW)]
, desired trough (traditional dosing) for gent/tobra? peak? - ANSWER>>trough: < 2
mcg/mL
peak: 5-10 mcg/mL
amoxicilin brand name - ANSWER>>Amoxil
what organisms do the penicillins cover? - ANSWER>>mainly gram (+), some gram (-)
which penicillin is the DOC in acute otitis media? - ANSWER>>amoxicillin
which penicillin has activity against PA? - ANSWER>>piperacillin
which penicillins do not require renal dosing? - ANSWER>>nafcillin
oxacillin
dicloxacillin
Does Amoxil suspension need to be refrigerated? - ANSWER>>no - stable for 14 days
at room temperature
how do you need to take Pen VK? - ANSWER>>on an empty stomach
what IV fluid is ampicillin only compatible with? - ANSWER>>NS
what are the main penicillin drug interactions? - ANSWER>>probenacid, allopurinol
- increased penicillin levels
Correct Answers | Verified | Updated 2024
MIC - ANSWER>>lowest drug concentration that prevents visibile microbial growth in
24 hours
What type of killing do carbapenems exhibit? - ANSWER>>time-dependent bactericidal
gram (+) bacteria species - ANSWER>>staph, strep, EC, clostridium, listeria
which antibiotics exhibit time-dependent killing? - ANSWER>>penicillins,
cephalosporins
how can you increase the killing of a time-dependent antibiotic? - ANSWER>>dose
more frequently, extend the infusion time
example of concentration-dependent antibiotic? - ANSWER>>aminoglycosides
(gentamicin, tobramycin, amikacin)
what are the bacteriostatic antibiotics (protein synthesis inhibitors)? -
ANSWER>>macrolides
aminoglycosides
tetracyclines
clindamycin
linezolid
quinupristin, dalfopristin
what is the MOA of penicillins, cephalosporins, carbapenems, and vancomycin? -
ANSWER>>cell wall inhibitors - bactericidal
,what general ADRs are the black box warning for aminoglycosides? -
ANSWER>>nephrotoxicity and neurotoxicity
what are the aminoglycosides? - ANSWER>>tobramycin
gentamicin
amikacin
what is the ratio of sulfamethoxazole to trimethoprim? - ANSWER>>always 5:1
what enzyme do sulfonamides inhibit? DI? - ANSWER>>2C8/9 - warfarin
what type of nephrotoxicity do aminoglycosides cause? - ANSWER>>ATN - acute
tubular necrosis
what weight do you use to dose aminoglycosides? - ANSWER>>IBW (unless TBW is
less)
*use ABW if obese ( > 30% IBW)
what organisms are aminoglycosides mainly active against? - ANSWER>>gram (-):
GNR, PA
extended interval dosing of the aminoglycosides? - ANSWER>>gent/tobra: 4-7 mg/kg
amikacin: 15-20 mg/kg
*draw random level within 6-16 hours after dose
adjust body weight (ABW) formula? - ANSWER>>IBW + [0.4(TBW - IBW)]
, desired trough (traditional dosing) for gent/tobra? peak? - ANSWER>>trough: < 2
mcg/mL
peak: 5-10 mcg/mL
amoxicilin brand name - ANSWER>>Amoxil
what organisms do the penicillins cover? - ANSWER>>mainly gram (+), some gram (-)
which penicillin is the DOC in acute otitis media? - ANSWER>>amoxicillin
which penicillin has activity against PA? - ANSWER>>piperacillin
which penicillins do not require renal dosing? - ANSWER>>nafcillin
oxacillin
dicloxacillin
Does Amoxil suspension need to be refrigerated? - ANSWER>>no - stable for 14 days
at room temperature
how do you need to take Pen VK? - ANSWER>>on an empty stomach
what IV fluid is ampicillin only compatible with? - ANSWER>>NS
what are the main penicillin drug interactions? - ANSWER>>probenacid, allopurinol
- increased penicillin levels
