PHAR 611 EXAM 1 WITH COMPLETE
QUESTIONS AND ANSWERS {
GUARANTEED A+}
What are some other terms used to describe ADRs (adverse drug
reactions)? (6) - ✔✔drug-induced disease, side effects, adverse drug
reaction, adverse drug event, drug related problem, untoward drug
reaction
What is an adverse drug reaction? - ✔✔any noxious, unintended, and
undesired effect that occurs at normal drug doses (WHO)
,alt definition: an effect produced by the use of a medication in the
recommended manner that is not the intended therapeutic effect of
the medication
Describe a Type A adverse drug reaction. - ✔✔- Augmented; are
extensions of a drug's known pharmacology
- are common and responsible for the majority of AEs
- usually are dose dependent and predictable
- ex: bleeding risk w/anticoagulants
Describe a Type B adverse drug reaction. - ✔✔- Bizarre; not due to any
known pharmacology of the drug & is a function of patient
susceptibility
- are uncommon but can be serious/life threatening
- usually NOT dose dependent and is unpredictable
- ex: anaphylaxis to penicillin
, What type of reactions are included in Type B ADRs? - ✔✔idiosyncratic
reactions (drug reactions that occur rarely and unpredictably amongst
the population), immunological and allergic reactions
Except for immediate hypersensitivity reactions, it usually takes about
_________ days before a patient exhibits hypersensitivity to a drug.
Although there is no max time for the occurrence of a reaction, most
reactions would've occurred within _____ weeks of initiation of
therapy. - ✔✔5 days; 12 weeks
Describe a Type C adverse drug reaction. - ✔✔- Chronic; dose and time
related (related to the cumulative dose)
- due to dose accumulation or w/prolonged use
- uncommon
- ex: adrenal suppression with corticosteroids; osteonecrosis of the jaw
with bisphosphonates
QUESTIONS AND ANSWERS {
GUARANTEED A+}
What are some other terms used to describe ADRs (adverse drug
reactions)? (6) - ✔✔drug-induced disease, side effects, adverse drug
reaction, adverse drug event, drug related problem, untoward drug
reaction
What is an adverse drug reaction? - ✔✔any noxious, unintended, and
undesired effect that occurs at normal drug doses (WHO)
,alt definition: an effect produced by the use of a medication in the
recommended manner that is not the intended therapeutic effect of
the medication
Describe a Type A adverse drug reaction. - ✔✔- Augmented; are
extensions of a drug's known pharmacology
- are common and responsible for the majority of AEs
- usually are dose dependent and predictable
- ex: bleeding risk w/anticoagulants
Describe a Type B adverse drug reaction. - ✔✔- Bizarre; not due to any
known pharmacology of the drug & is a function of patient
susceptibility
- are uncommon but can be serious/life threatening
- usually NOT dose dependent and is unpredictable
- ex: anaphylaxis to penicillin
, What type of reactions are included in Type B ADRs? - ✔✔idiosyncratic
reactions (drug reactions that occur rarely and unpredictably amongst
the population), immunological and allergic reactions
Except for immediate hypersensitivity reactions, it usually takes about
_________ days before a patient exhibits hypersensitivity to a drug.
Although there is no max time for the occurrence of a reaction, most
reactions would've occurred within _____ weeks of initiation of
therapy. - ✔✔5 days; 12 weeks
Describe a Type C adverse drug reaction. - ✔✔- Chronic; dose and time
related (related to the cumulative dose)
- due to dose accumulation or w/prolonged use
- uncommon
- ex: adrenal suppression with corticosteroids; osteonecrosis of the jaw
with bisphosphonates
