NURO 670 Midterm -
Renal-LFTs-Pancreas Exam
Study Guide
BUN- Answer blood urea nitrogen; 5-25 normal
byprod of nitrogenous metabolism
excreted by kidneys
azotemia- Answer increased nitrogenous waste
uremia- Answer toxic condition, kidneys unable to excrete urea + other toxins
what causes increased BUN?- Answer -increased protein catabolism (septic, trauma)
-decreased renal perfusion (prerenal)
-intrarenal dysfunction (nephrotic syndrome, meds)
-obstructive uropathy
-any pre/intra renal failure will produce DECREASE in GFR and DECREASE urea
excretion
**GI bleed? digestion of RBCs
increased BUN s/s- Answer fatigue, wkness, seizures, lethargy, confusion, pruritis
*uremic bleed? PLT dysfunctions
increased BUN tx- Answer determine + fix underlying cause.
-prerenal - improve perfusion
-intra - stop toxins/meds, tx cause
basically water the kidneys and dialyze
Creatinine definition- Answer byprod of creatinine phosphate metabolism
normal 0.6-1.5
male>female d/t muscle mass
, completely excreted by kidney - reflects GFR
what causes elevation in Cr?- Answer renal shit.
muscle wasting, HF, shock, rhabdo
BUN:Cr ratio- Answer 10:1 - intrarenal pathology
20:1 - prerenal pathology
Creatinine clearance- Answer indicative of GFR
compares amt of creatinine in urine to amt in blood/serum
male 125/min ; female 105/min
CrCl cockcroft gault equation- Answer (140-age) x IBW/72 x Cr(mg/dL) [women =
multiple by 0.85]
ideal body wt- Answer male = 50kg + (inch >60 x 2.3)
female = 45.5kg + (inch >60 x 2.3)
relationship of Cr vs GFR- Answer **doubling Cr = GFR decrease 50
Cr 1 = GFR 100
Cr 2 = 50
4 = 25
what labs can be used to determine renal function?- Answer urine Na - 20-40
FeNa - 1-2%
urine plasma/Cr ratio - 20-40
renal failure index - 1-2
urine plasma/osm ratio - >1
(normals are listed)
prerenal problem = what labs?- Answer urine Na <30
FeNa <1%
urine plasma/cr ratio >30
RFI <1
urine plasma/osm ratio >1.4
Renal-LFTs-Pancreas Exam
Study Guide
BUN- Answer blood urea nitrogen; 5-25 normal
byprod of nitrogenous metabolism
excreted by kidneys
azotemia- Answer increased nitrogenous waste
uremia- Answer toxic condition, kidneys unable to excrete urea + other toxins
what causes increased BUN?- Answer -increased protein catabolism (septic, trauma)
-decreased renal perfusion (prerenal)
-intrarenal dysfunction (nephrotic syndrome, meds)
-obstructive uropathy
-any pre/intra renal failure will produce DECREASE in GFR and DECREASE urea
excretion
**GI bleed? digestion of RBCs
increased BUN s/s- Answer fatigue, wkness, seizures, lethargy, confusion, pruritis
*uremic bleed? PLT dysfunctions
increased BUN tx- Answer determine + fix underlying cause.
-prerenal - improve perfusion
-intra - stop toxins/meds, tx cause
basically water the kidneys and dialyze
Creatinine definition- Answer byprod of creatinine phosphate metabolism
normal 0.6-1.5
male>female d/t muscle mass
, completely excreted by kidney - reflects GFR
what causes elevation in Cr?- Answer renal shit.
muscle wasting, HF, shock, rhabdo
BUN:Cr ratio- Answer 10:1 - intrarenal pathology
20:1 - prerenal pathology
Creatinine clearance- Answer indicative of GFR
compares amt of creatinine in urine to amt in blood/serum
male 125/min ; female 105/min
CrCl cockcroft gault equation- Answer (140-age) x IBW/72 x Cr(mg/dL) [women =
multiple by 0.85]
ideal body wt- Answer male = 50kg + (inch >60 x 2.3)
female = 45.5kg + (inch >60 x 2.3)
relationship of Cr vs GFR- Answer **doubling Cr = GFR decrease 50
Cr 1 = GFR 100
Cr 2 = 50
4 = 25
what labs can be used to determine renal function?- Answer urine Na - 20-40
FeNa - 1-2%
urine plasma/Cr ratio - 20-40
renal failure index - 1-2
urine plasma/osm ratio - >1
(normals are listed)
prerenal problem = what labs?- Answer urine Na <30
FeNa <1%
urine plasma/cr ratio >30
RFI <1
urine plasma/osm ratio >1.4
