Antipsychotics Exam Questions With
Accurate Answers
Schizophrenia dx
Ben 2 HaDeS
Behavior-disorganized-catatonia
Negative symptoms (emotional, social, cog. exp)
2 or more of these sxs
Hallucinations
Delusions-paranoid, bizarre
Speech- disorganized
*at least 2 for at least 6mos
Typical and atypical antipsychotics differ in
Side effects-not efficacy
Typical antipsychotics receptor affinity, which is associated with what side effects
more specific for blocking the D2 receptor-->motor and neuro side effects
Atypical antipsychotic receptor affinity
less for D2
blocks 5HT2A
metbolic issues
Metabolic issues r/t antipsychotics
obesity
, DM
hyperlipidemia
typical vs atypical antipsychotics
Efficacy and side effects of antipsychotics are derived from modulation of
DA receptors
DOPAMINE:
Drugs
psychOsis
Prolactin inhibition
Attention
Motivation
Involuntary movements
Nausea
Energy
Positive sx are reduced through
blocking DA in the mesolimbic pathway
*hypothesized to dampen salience of info - broken filtering mechanism
Positive sx
hallucinations
delusions
thought disorganization
Antipsyhocitcs increase prolactin
by blocking DA
DA itself inhibits prolactin via the tuberoinfundibular pathway
Accurate Answers
Schizophrenia dx
Ben 2 HaDeS
Behavior-disorganized-catatonia
Negative symptoms (emotional, social, cog. exp)
2 or more of these sxs
Hallucinations
Delusions-paranoid, bizarre
Speech- disorganized
*at least 2 for at least 6mos
Typical and atypical antipsychotics differ in
Side effects-not efficacy
Typical antipsychotics receptor affinity, which is associated with what side effects
more specific for blocking the D2 receptor-->motor and neuro side effects
Atypical antipsychotic receptor affinity
less for D2
blocks 5HT2A
metbolic issues
Metabolic issues r/t antipsychotics
obesity
, DM
hyperlipidemia
typical vs atypical antipsychotics
Efficacy and side effects of antipsychotics are derived from modulation of
DA receptors
DOPAMINE:
Drugs
psychOsis
Prolactin inhibition
Attention
Motivation
Involuntary movements
Nausea
Energy
Positive sx are reduced through
blocking DA in the mesolimbic pathway
*hypothesized to dampen salience of info - broken filtering mechanism
Positive sx
hallucinations
delusions
thought disorganization
Antipsyhocitcs increase prolactin
by blocking DA
DA itself inhibits prolactin via the tuberoinfundibular pathway
