Lehne's Pharmacology for Nursing Care 11th Edition By Jacqueline Burchum; Laura Rosenthal

Test Bank For Lehne's Pharmacology for Nursing Care
11th Edition By Jacqueline Burchum; Laura Rosenthal

gated open pores in the cytoplasmic membrane that regulate entry of calcium ions
into cells - ANSWER: Calcium channels

Calcium entry plays a critical role in the entry of what? - ANSWER: the function of
vascular smooth muscle (VSM) and the heart

In vascular smooth muscle, calcium channels regulate through what? - ANSWER:
contraction

What initiates the contractile process in VSM? - ANSWER: An action potential travels
down the surface of a smooth muscle cell, calcium channels open and calcium ions
flow inward

What happens when calcium channels are blocked in VSM? - ANSWER: Vasodilation
will result

Do CCBs have an effect on the veins? - ANSWER: No

CCBs act __________ on peripheral arterioles and arteries and arterioles of the heart
- ANSWER: selectively

In the heart, what do calcium channels help to regulate? - ANSWER: The
myocardium, SA node, and AV node

Calcium channels at their three sites in the heart are coupled to what receptors -
ANSWER: Beta1 adrenergic

In cardiac muscle, calcium entry have a positive or negative inotropic effect -
ANSWER: positive

Contractile force will diminish if calcium channels in the ________ and
____________ muscles are blocked - ANSWER: atrial and ventricular

What regulates the pacemaker activity of the SA node? - ANSWER: calcium influx

Does the discharge of the SA node increase or decrease when calcium channels are
open? - ANSWER: increase

The effect of calcium channel blockade (in SA node) is to - ANSWER: reduce heart
rate

, Regulation of _____________ plays a critical role in coordinating contraction of the
ventricles with contraction of the atria - ANSWER: AV conduction

The excitability of AV nodal cells is regulated by what? - ANSWER: calcium entry

The effect of calcium channel blockade (in AV node) is to - ANSWER: Decrease
velocity of conduction through the AV node

What similarities to beta blockers and CCBs have? - ANSWER: they have identical
effects on the heart
- reduce force of contraction
- slow heart rate
- suppress conduction through AV node

Nifedipine is the prototype of which CCB family - ANSWER: dihydropyridines

What is the only phenylalkylamine? - ANSWER: verapamil

what is the only benzothiazepine - ANSWER: dilitiazem

What calcium channel blocker affects the heart and blood vessels? - ANSWER:
Verapamil and diltiazem

What CCB acts mainly on blood vessels? - ANSWER: Nifedipine

What two dihydropyridines can help with migraines? - ANSWER: Nifedipine and
Nimodipine

What three dihydropyridines can help with angina? - ANSWER: Nifedipine,
amlodipine, Nicardipine

Verapamil and Diltiazem may be indicated for what conditions? - ANSWER: HTN
Angina
Dysrhythmias
Migraine

All CCBs are indicated for what? - ANSWER: HTN

What are the 5 direct effects Verapamil has on the heart/blood vessels? - ANSWER:
Blockade at:
1) peripheral arterioles causes dilation and thereby reduces arterial pressure
2) arteries and arterioles of the heart increases coronary perfusion
3) the SA node reduces heart rate
4) AV node decreases AV nodal conduction
5) in the myocardium decreases force of contraction