VUSN pharm exam 3 Study Guide with Complete Solutions

VUSN pharm exam 3 Study Guide with Complete Solutions Cholestyramine - Answer️️ -statin Action: reduces LDL binds with bile salt in intestines --> bile acids + cholesterols are eliminated in feces adverse effects: constipation, bloating, belching, esophageal irritation & obstruction Fibric Acid Derivatives - Answer️️ -gemfibrozil use: reduces VLDL & triglycerides action: inhibits breakdown of stored fats, uptake of fatty acids, triglyceride production adverse effects: N/V, cholelithiasis, inc INR w/ warfarin, GI comp Nicotinic Acid - Answer️️ -niacin use: reduces VLDL & LDL, triglycerides action: inhibits release of free fatty acids, increased lipoprotein lipase activity Side effects: flushing, itching, stimulation of prostaglandins, GI intolerance, myalgia ©SOPHIABENNETT@ Sunday, August 25, 2024 2:42 PM Vanderbilt University School of Nursing 2 *take aspirin before morning dose HMG - CoA reductase inhibitors - Answer️️ -Rosuvastatin action: inhibition of HMG-CoA reductase, reduces cholesterol synthesis & LDL *nocturnal dosing adverse effect: GI distress, rhabdomyolysis *discontinue in cases of: muscle pain, weakness, fatigue, fever monitor CK labs interactions: grapefruit, pomegranates beta blocker metoprolol - Answer️️ -use: HTN, chest pain, post MI, dysthymias, HF action: block B1, <B2, decrease HR & contractility, decrease renin, decrease PVR *negative chronotrope, isotrope routes: PO, IR, SR, IV, ophthalmologic contra: DM, chronic lung disease, HF on Dig, hyperthyroid, bradycardia, 2nd degree HB or greater, < 6yo interact: other antihypertensives, digoxin (increase bradycardia), neuromuscular, blocking agents ©SOPHIABENNETT@ Sunday, August 25, 2024 2:42 PM Vanderbilt University School of Nursing 3 Nurse Interventions (NI): orthostatic hypotnsn, monitor VS (BP, HR), edema Client edu: do not discontinue abruptly, taper after 2 wks, check bp & hr, report edema, report new chest pain alpha adrenergic blocker - Answer️️ -doxazosin use: decrease BP, bph action: alpha 1 blocker, decreases vasoconstriction (venous & arterial) S.E.: reflex tachycardia, orthostatic hypotnsn contra: liver disease, preg, low bp, children, EtOH, sildenafil NI: check HR & ortho hypo, check bp, pulse client edu: take at night, rise slowly, report dizziness/ syncope ACE inhibitors / Angiotensin II blockers - Answer️️ -Captopri