Pharmacology Psychiatric Mental Health
Nurse Practitioner exam with correct
answers
What are the five factors that influence absorption? - ANSWERS🔷🔶Gastric emptying
Time of contact with intestinal wall
Bowel perfusion
Food
Formation of non-absorbable complexes
Explain the hepatic first pass. - ANSWERS🔷🔶Part of the drug is metabolized by the liver before it
reaches the blood.
Explain bioavailability. - ANSWERS🔷🔶Percentage of administered drug that reaches systemic
circulation.
Name the 3 highly water-soluble drugs. - ANSWERS🔷🔶Lithium, Amisulpride, Paliperidone
What are the 7 inhibitors of CYP? - ANSWERS🔷🔶Paroxetine, Fluoxetine, Fluvoxamine,
Fluconazole, Ciprofloxacin, Ritonavir, Grapefruit juice
What are the 6 inducers of CYP? - ANSWERS🔷🔶Carbamazepine, Phenytoin, Phenobarbital,
Primidone, smoking, St-John's Wort
What are the 6 factors that influence pharmacokinetics? - ANSWERS🔷🔶Age, pregnancy, obesity,
sexe, comorbidities, genetics
Explain the half-life. - ANSWERS🔷🔶The time it takes for the concentration of a drug to be
reduced by 50%
, What are the 11 indications for TDM. - ANSWERS🔷🔶Non-compliance/toxicity
Lack of efficacy/adverse effects at normal dose
Relapse in maintenance treatment
Change in drug formulation
Pregnancy
Age
Comorbidities
Drug interactions
Change in BMI
Finding the optimal drug concentration
Genetic polymorphisms
What are the 4 factors influencing receptor binding? - ANSWERS🔷🔶Affinity
Specificity
Saturability
Reversibility
Define intrinsic activity. - ANSWERS🔷🔶The ability of a drug to initiate a response after binding to
a receptor
Define complete agonist vs. partial agonist. - ANSWERS🔷🔶Decreased intrinsic activity, decreased
pharmacological effect, good affinity with receptor
Define competitive antagonist vs. non-competitive antagonist. - ANSWERS🔷🔶Differences in dose
response curves
Increasing dose of agonist will change the response of a competitive antagonist.
What are the 4 targets of psychotropic drugs? - ANSWERS🔷🔶Transporters, G-coupled protein
receptor, ion channels, enzymes
Nurse Practitioner exam with correct
answers
What are the five factors that influence absorption? - ANSWERS🔷🔶Gastric emptying
Time of contact with intestinal wall
Bowel perfusion
Food
Formation of non-absorbable complexes
Explain the hepatic first pass. - ANSWERS🔷🔶Part of the drug is metabolized by the liver before it
reaches the blood.
Explain bioavailability. - ANSWERS🔷🔶Percentage of administered drug that reaches systemic
circulation.
Name the 3 highly water-soluble drugs. - ANSWERS🔷🔶Lithium, Amisulpride, Paliperidone
What are the 7 inhibitors of CYP? - ANSWERS🔷🔶Paroxetine, Fluoxetine, Fluvoxamine,
Fluconazole, Ciprofloxacin, Ritonavir, Grapefruit juice
What are the 6 inducers of CYP? - ANSWERS🔷🔶Carbamazepine, Phenytoin, Phenobarbital,
Primidone, smoking, St-John's Wort
What are the 6 factors that influence pharmacokinetics? - ANSWERS🔷🔶Age, pregnancy, obesity,
sexe, comorbidities, genetics
Explain the half-life. - ANSWERS🔷🔶The time it takes for the concentration of a drug to be
reduced by 50%
, What are the 11 indications for TDM. - ANSWERS🔷🔶Non-compliance/toxicity
Lack of efficacy/adverse effects at normal dose
Relapse in maintenance treatment
Change in drug formulation
Pregnancy
Age
Comorbidities
Drug interactions
Change in BMI
Finding the optimal drug concentration
Genetic polymorphisms
What are the 4 factors influencing receptor binding? - ANSWERS🔷🔶Affinity
Specificity
Saturability
Reversibility
Define intrinsic activity. - ANSWERS🔷🔶The ability of a drug to initiate a response after binding to
a receptor
Define complete agonist vs. partial agonist. - ANSWERS🔷🔶Decreased intrinsic activity, decreased
pharmacological effect, good affinity with receptor
Define competitive antagonist vs. non-competitive antagonist. - ANSWERS🔷🔶Differences in dose
response curves
Increasing dose of agonist will change the response of a competitive antagonist.
What are the 4 targets of psychotropic drugs? - ANSWERS🔷🔶Transporters, G-coupled protein
receptor, ion channels, enzymes
