Janeways Immunobiology 9th Edition by Kenneth Murphy; Casey Weaver |

Test bank for Janeways Immunobiology 9th Edition by
Kenneth Murphy; Casey Weaver | 9780815345053 | Chapter
1-16 | All Chapters with Answers and Rationals

Lectin - ANSWER: Carbohydrate-binding antimicrobial peptide. Includes RegIIIgamma and human
RegIIIalpha

Humoral fluid - ANSWER: Complement and other defensive proteins circulating in bodily fluid

5 categories of disease-causing agents - ANSWER: Bacteria, virus, fungi, helminth, protozoa

Composition of Gram positive bacterial cell wall - ANSWER: Peptidoglycan, Lipoteichoic acid, Teichoic
acid.

Composition of Gram negative bacterial cell wall - ANSWER: Smaller peptidoglycan, Lipoprotein,
Lipopolysaccharide

Zoonotic Infection - ANSWER: Disease originally endemic in non-human animals.

Cystic Fibrosis - ANSWER: Loss of function of epithelial chloride channel, causing dehydrated mucus.
Bacterial colonies typically form as epithelial cilia fail to move mucus out of body.

Function of lysozyme - ANSWER: Cleaves carbohydrate bonds in peptidoglycan layer of bacterial cell
walls.

Where are lysozyme and secretory phospholipase A2 found? - ANSWER: Tears, saliva, paneth cells of
small intestine.

Secretory phospholipase A2 - ANSWER: Basic enzyme that can enter bacterial cell wall to hydrolyze
phospholipids in plasma membrane.

Defensin structure - ANSWER: Amphipathic polypeptide.

Function of defensin proteins - ANSWER: Insert into hydrophobic region of membrane bilayer,
forming a pore upon contact with other inserted defensins.

Paneth cell locatied - ANSWER: Small intestinal crypts

Zymogen - ANSWER: Inactive enzyme precursor requiring hydrolysis of pro-region

Neutrophil primary granules - ANSWER: Lysosome-like vesicle containing antimicrobial agents.
Induced to fuse with phagosome. Contains neutrophil elastase

Neutrophil secondary granules - ANSWER: Store propeptide cathelicidins; activated upon fusion
w/primary granule.

Cathelicidins - ANSWER: Antimicrobial protein produced by neutrophil and macrophages, secreted by
keratinocytes and epithelia of lung and intestine.

Histatins - ANSWER: Produced in parotid, sublingual and submandibular glands. Are antifungal
peptides that promote rapid wound healing.

Complement proteins are produced mostly in the ________________ - ANSWER: Liver

, 3 pathways of complement activation - ANSWER: Classical, alternative, lectin

Binds to antigen:antibody complex and pathogenic surface - ANSWER: C1q

binds to carbohydrate structures (ex. mannose) - ANSWER: MBL/Ficolins
Properdin (factor P)

Activating enzymes - ANSWER: C1r
C1s
C2a
Bb
D
MASP-1, 2, 3

Surface-binding proteins and opsonins - ANSWER: C3b
C4b

Inflammatory mediators - ANSWER: C3a
C4a
C5a

Membrane-attack proteins - ANSWER: C5b
C6
C7
C8
C9

Complement receptors - ANSWER: CR1
CR2
CR3
CR4
CRIg

C3 convertase of lectin pathway - ANSWER: C4b2a

C3 convertase of classical pathway - ANSWER: C4b2a

C3 convertase of alternative pathway - ANSWER: C3bBb

Fluid phase C3 convertase - ANSWER: C3(H2O)Bb

Protein that stabilizes alternative and fluid phase convertase - ANSWER: Properdin (Factor P)

Surfactant protein SP-A and SP-D - ANSWER: Secreted in lung epithelia. Opsonize pathogens, but do
not interact with MASP and so do not activate complement

The pathogen sensor of the classical pathway - ANSWER: C1 complex

C1 activated by - ANSWER: Surface-bound antibody, direct pathogen surface.

C1 pathogen sensor subunit - ANSWER: C1q

C1 serine protease subunits - ANSWER: C1r and C1s (initially inactive)

Proteoglycan - ANSWER: Component of animal ECM in connective tissue

Peptidoglycan - ANSWER: Component of bacterial cell wall