ONC Study Revision Questions with Correct Answers

A 60-year-old female presents with persistent fatigue, night sweats, and painless swelling of cervical lymph nodes. Laboratory tests show an elevated LDH level. A lymph node biopsy reveals a diffuse large B-cell lymphoma. What is the most appropriate next diagnostic test to further characterize the extent of the disease? A) Bone Marrow Biopsy B) Chest X-ray C) PET-CT Scan D) Lumbar Puncture C) PET-CT Scan Lumbar puncture → if sinus, testicular, orbital, epidural, or BM involvement (wouldn't be the next best step) A 55-year-old female is diagnosed with non-Hodgkin's lymphoma, and the oncologist plans the staging of the disease. What system is commonly used for staging non-Hodgkin's lymphoma? A) Rai & Binet Staging B) Lugano classification C) TNM staging D) Bloom-Richardson grading B) Lugano classification → it's a type of Ann Arbor so if Ann Arbor is an opt & Lugano isn't... A 45-year-old male is diagnosed with non-Hodgkin's lymphoma (NHL). What is the most likely subtype of non-Hodgkin's lymphoma? A) Follicular Lymphoma B) Diffuse Large B-cell Lymphoma C) Mantle Cell Lymphoma D) Burkitt Lymphoma B) Diffuse Large B-cell Lymphoma aka Intermediate Which of the following is categorized as indolent non-Hodgkin's lymphoma? A) Diffuse Large B-cell Lymphoma B) Follicular Lymphoma C) Acute lymphoblastic leukemia D) Burkitt Lymphoma B) Follicular Lymphoma Which of the following is categorized as intermediate non-Hodgkin's lymphoma? A) Diffuse Large B-cell Lymphoma B) Follicular Lymphoma C) Acute lymphoblastic leukemia D) Burkitt Lymphoma A) Diffuse Large B-cell Lymphoma Which of the following is categorized as aggressive non-Hodgkin's lymphoma? A) Follicular Lymphoma B) Mantle Cell Lymphoma C) Burkitt Lymphoma D) Chronic Lymphocytic Leukemia (CLL) C) Burkitt Lymphoma --> aggressive, but highly curable cool cool A 25-year-old male with known HIV infection presents with rapidly growing jaw and facial masses, along with abdominal pain and distension. Biopsy reveals a starry-sky appearance with medium-sized, monomorphic lymphocytes. What is the most likely diagnosis? A) Diffuse Large B-cell Lymphoma B) Follicular Lymphoma C) Burkitt Lymphoma D) Mantle Cell Lymphoma C) Burkitt Lymphoma A 55-year-old female presents with persistent, itchy, and scaly patches on her skin. Biopsy results reveal abnormal T cells infiltrating the skin. Considering the cutaneous involvement, what is the most common form of cutaneous T-cell lymphoma? A) Mycosis Fungoides B) Sezary Syndrome C) Anaplastic Large Cell Lymphoma D) Peripheral T-cell Lymphoma, Not Otherwise Specified (PTCL-NOS) A) Mycosis Fungoides A 55-year-old male presents with erythematous, scaly patches on the skin, which have progressed over several years to covering 85% of the body. Biopsy reveals atypical T lymphocytes with cerebriform nuclei infiltrating the skin. Considering the advanced variant of this condition, what is the most likely diagnosis? A) Mycosis Fungoides B) Sezary Syndrome C) Dermatofibrosarcoma Protuberans D) Langerhans Cell Histiocytosis B) Sezary Syndrome A 45-year-old female is diagnosed with cutaneous T-cell lymphoma (CTCL), specifically mycosis fungoides. The disease is limited to the skin and has not progressed to advanced stages. What is the most appropriate initial treatment for this patient? A) Radiation therapy B) Systemic chemotherapy C) Stem cell transplantation D) Topical therapies (e.g., steroids, topical chemotherapy) D) Topical therapies (e.g., steroids, topical chemotherapy) A 60-year-old male with cutaneous T-cell lymphoma (CTCL) presents with widespread skin involvement and lymph node enlargement. The disease has progressed despite topical therapies. What is the next appropriate step in the treatment plan? A) Surgical excision of skin lesions B) Light therapy C) High-dose systemic chemotherapy D) Supportive care without active treatment B) Light therapy A 65-year-old female presents with weakness, easy bruising, and recurrent infections. Laboratory tests reveal anemia, thrombocytopenia, and an elevated serum IgM level. A bone marrow biopsy demonstrates infiltration by lymphoplasmacytic cells. The blood is in a hyperviscous state. Considering the patient's clinical and laboratory findings, what is the most likely diagnosis? A) Hodgkin's Lymphoma B) Chronic Lymphocytic Leukemia (CLL) C) Lymphoplasmacytic Lymphoma (LPL) D) Multiple Myeloma C) Lymphoplasmacytic Lymphoma (LPL)